BPS2025 Full Program

1660-Plat 8:30 am INVESTIGATION OF MICROTUBULE-CRMP2 ISOFORMS INTERACTION US ING HIGH-SPEED ATOMIC FORCE MICROSCOPY. Djamel Eddine Chafai , Saho Kitagawa, Syeda Rubaiya Nasrin, Akira Kakugo 1661-Plat 8:45 am FAST SIMULTANEOUS IMAGING OF MICROTUBULES AND THEIR ASSOCI ATED PROTEINS. Yazgan Tuna , Amer Al-Hiyasat, Jonathon Howard 1662-Plat 9:00 am TUBULIN CODE ERASER CCP5 BINDS BRANCH GLUTAMATES BY SUB STRATE DEFORMATION. Jiayi Chen , Elena A. Zehr, James M. Gruschus, Agnieszka Szyk, Yanjie Liu, Martin E. Tanner, Nico Tjandra, Antonina 9:15 am DIRECT QUANTIFICATION OF HUMAN ΑΒ-TUBULIN BINDING KINETICS AT MICROTUBULE ENDS REVEALS NUCLEOTIDE REGULATION OF END BINDING AFFINITY. Saradamoni Mondal , Eric Bonventre, Luke Rice, William O. Hancock 1664-Plat 9:30 am UNDERSTANDING MICROTUBULE NUCLEATION THROUGH THE CON FORMATIONAL DYNAMICS OF Α, Β, AND Γ-TUBULINS. Kenneth Tsui 1665-Plat 9:45 am DYNAMIC FORCE GENERATION AT MICROTUBULE TIPS CONTROL SPINDLE ARCHITECTURE AND SIZE. Lee-Ya Chu , Daniel Stedman, Julian Gannon, Susan Cox, Georgii Pobegalov, Maxim Molodtsov 1666-FlashTalk 10:00 am BOTTOM-UP COARSE-GRAINING REVEALS FORMATION OF STABLE PRO TOFILAMENT CLUSTERS AT MICROTUBULE PLUS-END TIPS. Weizhi Xue , Jiangbo Wu, Gregory A. Voth 1667-FlashTalk 10:05 am TUBULIN C-TERMINAL TAILS SHOW DISTINCT PATTERNS OF SELF-INTER ACTION. Patrick DeLear , David Sept 1668-FlashTalk 10:10 am EVIDENCE FOR STABLE LOW-TENSION KINETOCHORE-MICROTUBULE ATTACHMENTS. Khalid A. Al-Naemi , Roan Blakeley, Sean Moore, Ziad El-Hajj, Jackie Vogel Subgroup Chairs Meeting 9:00 am - 11:00 am, Room 518 Career Development Center Workshop How to Champion Yourself – in The Lab, at Work, in Your Career 9:30 am - 10:30 am, Room 409B When you champion yourself, you advocate for yourself and clarify to another party that you can help them. In this workshop, we will learn why and how to effectively champion ourselves every day and how by doing so, we enable the success of our colleagues, peers, and PI. Exhibitor Presentation Nuclera 9:30 am - 11:00 pm, Room 404AB Accelerating Protein Production: Leveraging eProtein Discovery™ for Rapid Screening and Biophysical Analysis in Drug Discovery In this session, we’ll explore advanced methods in recombinant protein screening, scale-up, and biophysical analysis to streamline protein production workflows. We’ll discuss innovative technology that enables rapid, medium-throughput screening of recombinant proteins, assess ing quality and functionality with speed and precision. By leveraging Roll-Mecak 1663-Plat

these tools, researchers can efficiently scale up protein production to meet the demands of diverse biophysical applications. Using eProtein Discovery’s integration with SPR binding analysis as an example, we’ll demonstrate how this approach can accelerate timelines and improve the workflow from initial screening to biophysical analysis, ultimately supporting drug discovery efforts with faster and more reliable protein data.. Roundtable discussion will explore how these proteins can be used in advanced biophysical techniques to unlock insights into molecular interactions and mechanisms. In this open table discussion experts will delve into the specific requirements for successful biophysical analysis, including the quantity, purity, and stability of proteins needed for differ ent techniques. Speaker Aujan Mehregan, Inside Sales Manager BD & Sales, Nuclera Exhibits 10:00 am - 4:00 pm, West Exhibit Hall Coffee Break 10:15 am - 11:00 am, West Exhibit Hall Symposium Intrinsically Disordered Proteins: A Peek Away from the Lamppost 10:45 am - 12:45 pm, Petree Hall C Chair Rohit Pappu, Washington University in St. Louis, USA No Abstract 10:45 am INTRINSICALLY DISORDERED PROTEIN CONFORMATIONS, CONDEN SATES AND CONSEQUENCES. Julie Forman-Kay No Abstract 11:10 am INTRINSIC DISORDER AS AN ORGANIZING PRINCIPLE FOR MEMBRANE CURVATURE. Jeanne Stachowiak 1669-Symp 11:35 am STEREOCHEMISTRY IN DISORDERED PROTEIN COMPLEXES. Birthe B. Kragelund 1670-SympSelect 12:00 pm DRUGGING INTRINSICALLY DISORDERED PROTEINS. Gabriella T. Heller No Abstract 12:20 pm MICROPHASE SEPARATION OF NUCLEAR PROTEINS COMPRISING RRMS AND DISORDERED REGIONS. Rohit Pappu Symposium Novel Mechanisms in Membrane Transport 10:45 am - 12:45 pm, Petree Hall D Chair Aravind Penmatsa, Indian Institute of Science, India No Abstract 10:45 am CRYO-EM OF PROTON PUMPS IN THE MAMMAL BRAIN. John 11:10 am LIPID AND VOLTAGE REGULATION OF NA + /H +. EXCHANGERS. David Drew 1672-Symp 11:35 am TRANSPORTERS AND CHANNELS IN BACTERIAL SURVIVAL. Inga Hänelt Rubinstein 1671-Symp

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