BPS2025 Full Program

Platform Enzyme Function, Cofactors, and Post-Translational Modifications 4:00 pm - 6:00 pm, Room 502B Co-Chairs Srijit Mukherjee, University of Colorado Boulder, USA Wenjun Xie, University of Florida, USA 1762-Plat 4:00 pm Travel Award Winner SUPREM: AN ENGINEERED NON-SITE-SPECIFIC M 6 A RNA METHYLTRANS FERASE WITH HIGHLY IMPROVED EFFICIENCY. Yoshiki Ochiai , Ben E. Clifton, Madeleine Le Coz, Marco Terenzio, Paola Laurino 1763-Plat 4:15 pm CULLIN5 SPECIFICALLY UBIQUITYLATES HISTONES H3 AND H4. Calvin P. Lin 1764-Plat 4:30 pm NEURODEGENERATIVE ATPASE VCP MUTANT AND WILD TYPE CO ASSEMBLY, STOICHIOMETRY, AND FUNCTIONAL ASSESSMENT BY SINGLE MOLECULE ASSAYS. Jingxuan Tang , Benjamin Dodd, Guoming Gao, Laxmikanta Khamari, Liuhan Dai, Andreas Schmidt, Stephanie L. Moon, Nils G. Walter 1765-Plat 4:45 pm CRYO-EM STRUCTURES OF CHLOROPLAST GLUTAMYL ENDOPEPTIDASE DEFINE ITS CATALYTIC MECHANISM. Jacqueline Ehrlich , Toshimitsu Kawate 1766-Plat 5:00 pm PEPTIDE POST-TRANSLATIONAL MODIFICATION DETECTION BASED ON ENGINEERED AEROLYSIN NANOPORE. Yan Gao , Hongyan Niu, Meng-Yin Li, Jie Jiang, Jun-ge li, Yi-Tao Long 1767-Plat 5:15 pm PROTEOLYTIC PERFORMANCE IS DEPENDENT ON BINDING EFFICIENCY, PROCESSIVITY AND TURNOVER: SINGLE MOLECULE INSIGHTS. Emily W. Sørensen , Freya Reinhold, Andreas Faber, Steen W.B. Bender, Jacob Kæstel-Hansen, Jeannette Lundin, Errika Voutyritsa, Per Hedegård, Sune M. Christensen, Nikos S. Hatzakis 1768-Plat 5:30 pm LEVERAGING GENERATIVE AI AND MOLECULAR MODELING TO UNVEIL ELECTROSTATIC CATALYSIS IN ENZYME ACTIVITY. Wenjun Xie 1769-FlashTalk 5:45 pm THE SYNTHESIS OF NEUROMODULATORY MOLECULES BY A GUT MI CROBIAL GLUTAMATE DECARBOXYLASE. Pavani Dadi , Clint W. Pauling, Abhishek Shrivastava, Dhara Shah 1770-FlashTalk 5:50 pm Canceled BREAKING FREE FROM “PHOSPHO-MIMETICS”: RECENT ADVANCES IN GENETIC CODE EXPANSION FOR STUDYING AUTHENTICALLY PHOSPHOR YLATED PROTEINS. Richard B. Cooley , Ryan A. Mehl 1771-FlashTalk 5:55 pm CARTOGRAPHY OF ELECTRIC FIELDS IN ENZYME CATALYSIS. Srijit Mukherjee , Steven D.E. Fried, Yuezhi Mao, Steven G. Boxer

1751-FlashTalk Travel Award Winner EXTENDING CONSTANT-PH MOLECULAR DYNAMICS TO MULTIPLE FORCE FIELDS. Joao G.N. Sequeira , Adrian E. Roitberg, Miguel Machu queiro Platform Protein Assemblies 4:00 pm - 6:00 pm, Room 502A Co-Chairs Ella de Csillery, University of Cambridge, United Kingdom Francis O’Reilly, NCI, NIH, USA 1752-Plat 4:00 pm Cancelled MULTISCALE COMPUTATIONAL STUDIES REVEAL KEY INSIGHTS INTO THE MOLECULAR PROCESSES UNDERLYING THE HIV-1 VIRUS LIFECYCLE. Gregory A. Voth 1753-Plat 4:15 pm ELASTICITY OF THE HIV-1 CORE FACILITATES NUCLEAR ENTRY AND INFECTION. Juan R. Perilla , Akshay Deshpande, Alexander J. Bryer, Jona than R. Andino-Moncada, Jiong Shi, Jun Hong, Cameron Torres, Shimon Harel, Francis Ashwanth, Christopher Aiken, Itay Y. Rousso 1754-Plat 4:30 pm THE CHOREOGRAPHY AND MECHANISM UNDERLYING REOVIRUS AS SEMBLY AND REPLICATION. Xiaoyu Liu 1755-Plat 4:45 pm STRUCTURAL AND FUNCTIONAL INSIGHTS INTO NLR FAMILY INTERAC TIONS WITH NLRP3 AND MITOCHONDRIAL DNA. Julia E. Cabral , Haitian Zhou, Minh Anh Pham, Sophia Lin, Reginald McNulty 1756-Plat 5:00 pm THE ARCHITECTURE OF THE PROTEASOME INTERACTOME BY STRUC TURAL PROTEOMICS. Kitaik Lee, Hitendra Negi, Sunny Truslow, Katerina Atallah-Yunes, Kylie Walters, Francis J. O’Reilly 1757-Plat 5:15 pm MULTISCALE MODELING OF THE NUCLEAR BASKET. Neelesh Soni , Trevor V. Eeuwen, Christopher Caffalette, Kelly Molloy, Digvijay Singh, Joshua Hutchings, Javier Fernandez-Martinez, Ignacia Echeverria, Eliza beth Villa, Brian T. Chait, Michael P. Rout, Andrej Sali 1758-Plat 5:30 pm Travel Award Winner QUANTIFYING AND PREDICTING ANTIBODY NON-SPECIFICITY IN THE CLINICAL LANDSCAPE: MICROFLUIDICS AND MACHINE LEARNING. Ella de Csillery , Hannes Ausserwöger, Marc Oeller, Isabel Waibel, Rahmad Akbar, Alexandru Abrudan, Georg Krainer, Gaetano Invernizzi, Paolo Arosio, Nikolai Lorenzen, Tuomas Knowles 1759-FlashTalk 5:45 pm DECODING SMALL MOLECULE-MEDIATED GNE ASSEMBLY INHIBITION MECHANISM USING MASS PHOTOMETRY (ISCAM). Nico Boback , San tiago Di Lella, Jacob Gorenflos López, Christian P.R. Hackenberger, Daniel Lauster 1760-FlashTalk 5:50 pm UNDERSTANDING INTERACTIONS BETWEEN THE MITOCHONDRIAL PORIN VDAC2 AND THE PRO-APOPTOTIC PROTEIN BAX. Varun Ravishankar , Laidy Maidel Alvero González, Valerie Prima, Maria Queralt-Martin, Guillaume Gerbaud, Lucie Bergdoll 1761-FlashTalk 5:55 pm ANTAGONIST-TO-AGONIST SWITCH DRIVES HIGHER ORDER OLIGOMER IZATION IN THE MINERALOCORTICOID RECEPTOR. Julián Weller-Pérez, Zuleima Ramos-Hernández, Diego Alvarez de la Rosa 5:55 pm

T U

E S

D A Y

114