BPS2025 Full Program

Platform Ligand-Gated Channels 4:00 pm - 6:00 pm, Room 501ABC

Platform Cytoskeleton: Mechanics, Dynamics, and Motility II 4:00 pm - 6:00 pm, Room 511ABC Co-Chairs Jorine Eeftens, Radboud University Nijmegen, The Netherlands Catherine Galbraith, Oregon Health and Science University, USA 1782-Plat 4:00 pm CHEMICAL COMPENSATION TO MECHANICAL LOSS VIA PI3K/AKT-NHE1 CROSSTALK. Qin Ni , Zhuoxu Ge, Anindya Sen, Konstantinos Konstanto poulos, Sean Sun 1783-Plat 4:15 pm Travel Award Winner THE MECHANICAL ENERGY COST OF DIVISION IS MAXIMIZED DURING SHAPE ELONGATION IN DIVIDING MODEL CELLS. Ryota Sakamoto , Michael P. Murrell 1784-Plat 4:30 pm Travel Award Winner ROBUST QUANTIFICATION OF CELLULAR AND NUCLEAR MECHANICS. Wessel Rodenburg, Jorine M. Eeftens 1785-Plat 4:45 pm CELLULAR PROTRUSION GENERATION AND LENGTH SCALE DEPEND ON CURVATURE CUES AND ACTIN NETWORK BALANCES. J. Michael Henderson , Feng-Ching Tsai, Nina Ljubojevic, Sevan Belian, Thibault Chaze, Mariette Matondo, Yosuke Senju, Pekka Lappalainen, Patricia M. Bassereau, Chiara Zurzolo 1786-Plat 5:00 pm LOCAL CYTOPLASMIC TRADEWINDS DIRECT SOLUBLE PROTEINS TO THEIR TARGETS. Catherine G. Galbraith , Brian P. English, Ulrike Boehm, James Galbraith 1787-Plat 5:15 pm TAU HYPERPHOSPHORYLATION IMPAIRS COOPERATIVE BINDING TO MI CROTUBULES AND PERTURBS ORGANELLE TRAFFICKING IN NEURONS. Daniel Beaudet , Christopher L. Berger, Adam G. Hendricks 1788-Plat 5:30 pm CONNECTIVITY AND CONTRACTION IN CYTOSKELETAL NETWORKS. Michael Norman, Annamarie Leske, Julio M. Belmonte 1789-FlashTalk 5:45 pm NUMA MECHANICALLY REINFORCES SPINDLE POLES INDEPENDENTLY OF DYNEIN THROUGH SELF-INTERACTIONS. Nathan Cho , Sophie Dumont 1790-FlashTalk 5:50 pm 3D-PRINTING CYTOSKELETAL NETWORKS: REACTIVE OXYGEN SPECIES INDUCE A SURGE IN ACTIN POLYMERIZATION. Thomas Litschel , Dimi trios Vavylonis, David A. Weitz 1791-FlashTalk 5:55 pm KINESIN-1 AUTOINHIBITION TUNES CARGO TRANSPORT BY MOTOR ENSEMBLES. Brandon M. Bensel , Patricia M. Fagnant, Samantha Beck Previs, Kathleen M. Trybus, Sam Walcott, David M. Warshaw

T U

Co-Chairs Eric Gibbs, Case Western Reserve University, USA Mae Weaver, University at Buffalo (SUNY), USA 1772-Plat 4:00 pm

E S

CALCIUM MODULATES NMDA RECEPTOR OPEN CHANNEL BLOCKERS THROUGH TWO DISTINCT ALLOSTERIC PATHWAYS. Mae G. Weaver , Gabriela K. Popescu 1773-Plat 4:15 pm TEMPERATURE-RESOLVED CRYO-EM REVEALS GLUTAMATE GATING OF AMPA RECEPTORS. Anish K. Mondal , Elisa Carrillo, Vasanthi Jayaraman, Edward C. Twomey 1774-Plat 4:30 pm VISUALIZING SINGLE-MOLECULE NANODYNAMICS OF AMPA-TYPE GLUTAMATE RECEPTORS BY HIGH-SPEED ATOMIC FORCE MICROSCOPY. Mikihiro Shibata , Ayumi Sumino, Takashi Sumikama, Yimeng Zhao, Motoyuki Hattori 1775-Plat 4:45 pm GATING AND REGULATION OF KAINATE RECEPTORS. Shanti Pal Gangwar , Maria V. Yelshanskaya, Kirill D. Nadezhdin, Thomas P. Newton, Laura Yen, Muhammed Aktolun, Maria G. Kurnikova, Alexander I. Sobo levsky 1776-Plat 5:00 pm THE MECHANISM OF PIP2 INHIBITION OF ROD CYCLIC NUCLEOTIDE GATED CHANNEL. Taehyun Park , Crina M. Nimigean 1777-Plat 5:15 pm ASYNCHRONOUS SUBUNIT TRANSITIONS PRECEDE ACETYLCHOLINE RECEPTOR ACTIVATION. Mackenzie J. Thompson, Christian J.G. Tessier, Anna Ananchenko, Francois Dehez, Hugues Nury, Corrie J.B. daCosta, Eleftherios Zarkadas, John E. Baenziger 1778-Plat 5:30 pm STRUCTURAL STUDIES OF HETEROMERIC GLYCINE RECEPTOR ACTIVA TION BY ORTHOSTERIC AND ALLOSTERIC AGONISTS. Eric Gibbs , Sudha Chakrapani, Emily Klemm, Philip C. Biggin, David Seiferth, Bjarne Fed dersen 1779-FlashTalk 5:45 pm HUMAN P2X4 RECEPTOR GATING IS MODULATED BY A STABLE CYTO PLASMIC CAP AND PUTATIVE LIPID BINDING SITES. Tommy Shi , Ismayn Ditter, Adam Oken, Steven E. Mansoor 1780-FlashTalk 5:50 pm DIRECT INTERACTIONS WITH THE NANODISC SCAFFOLD ALTER THE STRUCTURE OF A PENTAMERIC LIGAND-GATED ION CHANNEL. Vikram Dalal , Wayland W. Cheng 1781-FlashTalk 5:55 pm CRYO-EM STRUCTURES AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN TMEM16E SCRAMBLASE AND GDD ASSOCIATED MUTATIONS. Eleonora Di Zanni , Nicole Rychlik, Zhang Feng, Elizabeth Kim, Alessio Accardi

D A Y

115