BPS2025 Full Program

2150-Pos Travel Award Winner HOW DO IONS LEAK ACROSS THE ATP SYNTHASE TRANSMEMBRANE DOMAIN? STRUCTURAL CONSEQUENCES OF C-RING MUTATIONS. Sarah M. Crotzer , Qi Wang, David Koshkin, Elizabeth A. Jonas, Sally C. Pias Voltage-Gated Ca Channels (Boards B345 - B353) 2151-Pos Board B345 HORMONE-BASED MATURATION ENHANCES PHARMACOLOGICAL RE SPONSES OF IPSC-DERIVED CARDIOMYOCYTES. Daiana C.O. Vieira , John W. Hussey, Amy S. Lee, Emma G. Gudmundsson, Josiah O. Owoyemi, Olutomiwa Fadiran, Deborah DiSilvestre, Ivy E. Dick 2152-Pos Board B346 CALMODULATION OF NATIVE L-TYPE CALCIUM CURRENTS IN CARDIO MYOCYTES. Juan Zhao , Marlena Broszczak, Lucie Parent 2153-Pos Board B347 DIFFERENTIAL REGULATION OF CURRENT KINETICS BY BETA SUBUNITS IN N-TYPE CALCIUM CHANNEL. Jin-nyeong Woo , Byung C. Suh 2154-Pos Board B348 LRRC10 EXERTS L-TYPE CA 2+ CURRENT-SPECIFIC MODULATION THROUGH INTERACTION WITH THE N-TERMINUS OF CA V 1.2. Natthaphat Siri-Angkul , Marites T. Woon, Zachery R. Gregorich, Olu funke Olorundare, Youngsook Lee, Timothy J. Kamp 2155-Pos Board B349 PATHOGENIC CAV 1.4 VARIANTS DIFFERENTIALLY AFFECT RETINAL PATHWAYS. Matthias Ganglberger , Lucia Zanetti, Tobias Kipura, Uwe Lux, Alexander Günther, Bettina Wagner, Regine Mühlfriedel, Dagmar Knoflach, Emilio Casanova, Thomas Rülicke, Mathias Seeliger, Johann Brandstätter, Marcel Kwiatkowski, Hartwig Seitter, Alexandra Koschak 2156-Pos Board B350 ROLE OF PI(4,5)P2 IN REGULATING SARCOLEMMAL ABUNDANCE OF CARDIAC L-TYPE CAV1.2 CHANNELS. Alexandre Dantas Costa , Rose E. Dixon, Eamonn Dickson 2157-Pos Board B351 A BI-DIRECTIONAL BINDING SITE LINKING Α 2 Δ-1 SUBUNIT TO VOLTAGE SENSOR GATING CHARGES REGULATES THE ACTIVATION KINETICS OF CA V 1.1 CALCIUM CHANNELS. Martin C. Heiss , Monica Fernandez-Quin tero, Marta Campiglio, Bernhard E. Flucher 2158-Pos Board B352 Travel Award Winner TIGHT REGULATION OF BIN1 IS ESSENTIAL FOR Β -ADRENERGIC RESPON SIVITY IN THE HEART. Silvia G. del Villar , Maartje F. Westhoff, Danica W. Ito, Eamonn J. Dickson, Rose E. Dixon 2159-Pos Board B353 VOLTAGE GATED CALCIUM CHANNELS IN MOUSE RETINAL BIPOLAR CELLS. Elisa C. Roth , Hartwig Seitter, Matthias Ganglberger, Lucia Zanetti, Marta Campiglio, Nadine J. Ortner, Georgios Fotakis, Zlatko Trajanoski, Alexandra Koschak TRP Channels (Boards B354 - B375) 2160-Pos Board B354 COOPERATIVITY AND ACTIVATION MODE CROSS-TALK IN HUMAN TRPV1 CONCATEMERS. Helen F. Mann , Dustin Luu, Anna-Marie Agyepong, Wade D. Van Horn 2161-Pos Board B355 FUNCTIONAL ANALYSIS OF THE PREGNENOLONE SULPHATE POCKET OF TRANSIENT RECEPTOR POTENTIAL MELASTATIN SUBFAMILY 3. Matthew C.S. Denley , Charlotte Godfrey, Kenton Swartz Board B344

2162-Pos Board B356 PROBING THE ACTIVATION MECHANISMS OF TRP CHANNELS: THE ROLE OF THE VSLD DOMAIN MOVEMENTS. Jian Huang , Harshavardhan Chilu kuri Savitrinarayana, Jianhan Chen 2163-Pos Board B357 TRPV3 ACTIVATION BY DIFFERENT AGONISTS ACCOMPANIED BY LIPID DISSOCIATION FROM THE VANILLOID SITE. Kirill D. Nadezhdin, Ar thur Neuberger, Lena S. Khosrof, Irina Talyzina , Jeffrey Khau, Maria V. Yelshanskaya, Alexander I. Sobolevsky 2164-Pos Board B358 ARRHYTHMOGENIC ROLE OF TRPC CHANNELS IN CPVT. Nadezhda Fe felova, Sri Harika Pamarthi, Bjorn C. Knollmann, Zhilin Qu, Lai-Hua Xie 2165-Pos Board B359 WHEN & WHERE: TRPA1 TRAFFICKING AND TURNOVER. Camila Garcia , Candice E. Paulsen 2166-Pos Board B360 ELUCIDATING THE MECHANISM OF TRPA1 DESENSITIZATION. Gregory Board B361 LYSOSOMAL CA 2+ RELEASE THROUGH TRPML1 CONTRIBUTES TO AR RHYTHMIA AFTER MYOCARDIAL INFARCTION. An Xie , Gyeoung-Jin Kang, Hong Liu, Eun Ji Kim, Feng Feng, Samuel C. Dudley 2168-Pos Board B362 MOLECULAR DETERMINANTS OF INHIBITION OF TRPV3 CHANNEL BY IN TRACELLULAR POLYAMINES. Jingying Zhang, Peng Yuan, Colin G. Nichols, Grigory Maksaev 2169-Pos Board B363 MOLECULAR DETERMINANTS OF ARACHIDONIC ACID ACTIVATION OF THE TRPV4 CHANNEL. Aravind Parthasarathy , Gayathri K. Natarajan, Andriy Anishkin, Wai-Meng Kwok, David X. Zhang 2170-Pos Board B364 HYPOMAGNESEMIA PROMOTES ATRIAL FIBRILLATION RISK BY TRPM7 MEDIATED ACTIVATION OF INFLAMMATION, OXIDATIVE STRESS, AND SR DIASTOLIC CA 2+ LEAK. Man Liu , Hong Liu, Mitchell C. Neumann, Xiaoxu Zhou, Samuel C. Dudley 2171-Pos Board B365 CRYO-EM STRUCTURE-BASED INVESTIGATION OF STOICHIOMETRY AND ION PERMEABILITY OF TRPC1/C4 HETEROMER. Jinhyeong Kim , Jongdae Won, Jinsung Kim, Juyeon Ko, Christine Haewon Park, Byeongseok Jeong, Sang-Eun Lee, Hyeongseop Jeong, Sun-Hong Kim, HyunWoo Park, Insuk So, Hyung Ho Lee 2172-Pos Board B366 MOLECULAR BASIS OF NEUROSTEROID AND ANTICONVULSANT REGULATION OF NOCICEPTIVE TRPM3 ION CHANNEL. Cheon-Gyu Park , Ying Yin, Shasha Feng, Ziqiang Guan, Hyuk-Joon Lee, Feng Zhang, Kedar Sharma, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee 2173-Pos Board B367 DE NOVO DESIGNED PEPTIDIC MOLECULES TARGETING THE TRPV1 INTRACELLULAR DOMAIN. Zhihao Yao , Phuong T. Nguyen, Vladimir Yarov-Yarovoy, Jie Zheng 2174-Pos Board B368 ELUCIDATING THE MOLECULAR AND STRUCTURAL MECHANISMS OF A TRPA1 CHANNELOPATHY. Isabel Romov Quevedo 2167-Pos

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