BPS2025 Full Program

2175-Pos Board B369 DUAL ROLE OF RENAL TRPM3 CHANNELS IN BLOOD PRESSURE REGULA TION. José R. López López , Jorge Rojo-Mencia, Lucia Alonso-Carbajo, Karel Talavera, Pilar Cidad, Esperanza Alonso, M. Teresa Perez-Garcia 2176-Pos Board B370 TRANSIENT RECEPTOR POTENTIAL VANILLOID 4 INHIBITS CARDIAC AUTOPHAGY IN AGING & ISCHEMIA-REPERFUSION INJURY. Matthew R. Hayden , Tim Domeier 2177-Pos Board B371 MOLECULAR AND STRUCTURAL BASIS OF THE REGULATION OF TRPP2 CHANNEL BY SMALL MOLECULE LIGANDS. Zhifei Wang, Mengying Chen, Qiang Su, Tiago Da Costa Morais, Yan Wang, Feng Qian, Yigong Shi, Yong Yu 2178-Pos Board B372 ELUCIDATING THE PKD2L1 PHARMACOPHORE THROUGH HTS & STRUC TURAL ANALYSIS. Eduardo Guadarrama , Paul G. DeCaen 2179-Pos Board B373 TRPM8 CHANNELS IN VASCULAR FUNCTION: INSIGHTS FROM KNOCK OUT MOUSE MODELS AND HUMAN GENETIC VARIANTS. M. Teresa Perez-Garcia , Diego A. Peraza, Lucia Alonso-Carbajo, Alice Giontella, Karel Talavera, Pilar Cidad, Olle Melander, Jose R. Lopez-Lopez 2180-Pos Board B374 TUNING CALCIUM SENSITIVITY OF TRPM4 BY PIP2. Yuhua Tian , Abdullah A. Al Tekreeti, Adriana Hernández González, Yanxiao Han, Kyle Rouen, Igor V. Vorobyov, Vladimir Yarov-Yarovoy, Jie Zheng 2181-Pos Board B375 EVIDENCE OF DIFFERENTIAL EMERGENCE OF THE HUMAN TRPM8 CHANNEL COLD- AND MENTHOL-SENSING FUNCTIONS. Dustin D. Luu , Nikhil Ramesh, I. Can Kazan, Karan H. Shah, Gourab Lahiri, Miyeko D. Mana, S. Banu Ozkan, Wade D. Van Horn Ligand-Gated Channels II (Boards B376 - B390) 2182-Pos Board B376 DIFFERENTIAL BINDING AND ACTION OF NEUROSTEROIDS IN Β 3 HOMOPENTAMERIC GABA A RECEPTOR. Satoshi Koyama , Zhihui He, John R. Bracamontes, Gustav Akk, Alex S. Evers 2183-Pos Board B377 CHARACTERIZATION OF AN OPEN-STATE GABA A RECEPTOR USING IN SILICO MUTAGENESIS AND MOLECULAR DYNAMICS SIMULATIONS. Ayobami Diyaolu , Peter Obi, Senthil Natesan 2184-Pos Board B378 MOLECULAR SIMULATION REVEALS ION CONDUCTION THROUGH A CONSERVED LATERAL PATHWAY IN CATIONIC PENTAMERIC LIGAND-GAT ED ION CHANNELS. Mark J. Arcario , Jerome Henin, Grace H. Brannigan, Wayland W. Cheng 2185-Pos Board B379 INVESTIGATION OF GABAERGIC COMMUNICATION WITHIN THE AXONS OF PRIMARY SENSORY NEURONS IN A MICROFLUIDIC CULTURE SYS TEM. Sofia Figoli , Nikita Gamper 2186-Pos Board B380 IS TC2559 AN ALLOSTERIC SUPER-AGONIST AT HIGH SENSITIVITY (Α4) 2 (Β2) 3 NICOTINIC ACETYLCHOLINE RECEPTORS? Franco Viscarra, Teresa Minguez Vinas, Isabel Bermudez, Philip C. Biggin 2187-Pos Board B381 A CRITICAL ROLE FOR INTERDOMAIN DISTANCE IN ALLOSTERIC COM MUNICATION IN PLGICS. Tianle Chen , Claudio F. Grosman, Emad Tajkhorshid

2188-Pos Board B382 DIVERGENT MECHANISMS OF SMALL-MOLECULE INHIBITION IN A HUMAN RHO1 GABA A RECEPTOR. Chen Fan, John Cowgill, Rebecca J. Howard , Erik Lindahl 2189-Pos Board B383 VESTIBULAR MODULATION BY STIMULANT DERIVATIVES IN A PENTA MERIC LIGAND-GATED ION CHANNEL. Olivia Andén , Emelia Karlsson, Chen Fan, Zaineb Fourati, Ahmed Haouz, Marc H. Delarue, Rebecca J. Howard, Erik R. Lindahl 2190-Pos Board B384 INVESTIGATING RIC-3 AND 5-HT3A RECEPTOR INTERACTIONS IN NEU RONAL CELLS. Nermina Sarayli Belirgen , Quynh Hoa Do, Austin D. Rodg ers, Clinton MacDonald, Rhea Ramani, Cade Perkins, Joshua J. Theriot, Petar Grozdanov, Michaela Jansen 2191-Pos Board B385 EFFECTS OF RIC-3 STRUCTURAL DETERMINANTS ON THE FUNCTIONAL SURFACE EXPRESSION OF 5-HT 3A AND Α7 NACH RECEPTORS. Quynh Hoa Do , Michaela Jansen 2192-Pos Board B386 STRUCTURAL BASIS FOR ALLOSTERIC MODULATION OF THE 5-HT 3A R. Kevin C. Felt , Anshul Assaiya, Henock Befekadu, Madeleine Stauffer, Sudha Chakrapani 2193-Pos Board B387 AN ORTHOSTERIC LIGAND BINDING SITE IN THE ACCESSORY SUBUNIT OF ALPHA3BETA4 NICOTINIC ACETYLCHOLINE RECEPTORS IS REVEALED BY COVALENT MODIFICATION. Gauri C. Kulkarni , Megan J. Jurek, An drew P. Riley, Christian J. Peters 2194-Pos Board B388 THE B4 B5 LINKER OF THE GABAR A1 SUBUNIT REGULATES THE EFFICA CY OF POSITIVE AND NEGATIVE BENZODIAZEPINE MODULATION. John C. Merrick , Lucas M. Blecker, Cynthia Czajkowski 2195-Pos Board B389 ASYMMETRIC ACTIVATION OF A HOMOPENTAMERIC ION CHANNEL GLIC REVEALED BY CRYO-EM. Zhuowen Li, Sandip Basak 2196-Pos Board B390 THE ‘NATURE’ AND MECHANISM OF AGONIST BINDING TO THE HIGH AFFINITY FUNCTIONALLY OPEN STATE OF ACETYLCHOLINE RECEP TORS. Nadira Khatoon, Tapan K. Nayak Ion Channels, Pharmacology, and Disease II (Boards B391 - B417) 2197-Pos Board B391 MECHANISMS BEHIND REDUCED CALCIUM CURRENTS IN THE AGED CARDIAC PACEMAKER. Roxanne Madden , Oscar Vivas, Claudia M. Moreno 2198-Pos Board B392 AT THE CROSSROADS OF DISEASE TREATMENTS: TARGETING NA V CHAN NELS FOR BOTH BREAST CANCER AND CHRONIC PAIN THERAPY. Khoa Ngo , Vladimir Yarov-Yarovoy, Igor V. Vorobyov, Colleen E. Clancy 2199-Pos Board B393 SYNAPSING LIVING NEURONS WITH MULTIPLE IN SILICO NEURONS IN REAL TIME USING DYNAMIC CLAMP. Mark W. Nowak , Rafael V. Ortiz, Leigh Korbel, Lars Nilsson, Michael Hines, Nicholas T. Carnevale, Randall L. Rasmusson, Glenna Bett

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