BPS2025 Full Program

2200-Pos Board B394 AN ACTIVATOR MIMICS THE EFFECTS OF A BK CHANNELOPATHY MUTATION BY TARGETING ITS ALLOSTERIC PATHWAY TO OPEN THE PORE. Guohui Zhang , Xianjin Xu, Yuyin Wang, Rui Duan, Jingyi Shi, Lu Han, Borui Zhang, Huanghe Yang, Xiaoqin Zou, Jianmin Cui 2201-Pos Board B395 CANNABINOID INHIBITION OF MECHANOSENSITIVE K + CHANNELS. Trevor Docter , Ben Sorum, Rahul Deshmane, Cody Doubravsky, Steve Board B396 DEVELOPMENT AND EVALUATION OF NOVEL SOLUTION PAIRS TO ENHANCE SEAL RESISTANCE IN AUTOMATED PATCH CLAMP EXPERI MENTS. Catherine Hodgson, Edward Stevens, Andrew F. James, Anissa Bara, Beatrice Badone, Damian C. Bell, Daniel R.P. Sauter , Gary Clark 2203-Pos Board B397 ESSENTIAL ROLE OF CA 2+ SIGNALING DUE TO RYR2/FKBP12.6 DISSOCIA TION IN DIABETIC VASCULAR DEMENTIA. Yong-Xiao Wang , Yun-Min Zheng 2204-Pos Board B398 NS309 FUNCTIONS AS A SUPERAGONIST FOR THE CALCIUM-ACTIVATED POTASSIUM CHANNEL KCA3.1. Joshua Nasburg , Kyle Rouen, Connor Dietrich, Heesung Shim, Miao Zhang, Igor V. Vorobyov, Heike Wulff 2205-Pos Board B399 Travel Award Winner INVESTIGATING THE MECHANISMS OF SK2 CHANNEL MODULATION FOR ATRIAL FIBRILLATION THERAPY. Woori Choi , Ryan L. Woltz, Miao Zhang, Yanxiao Han, Khoa Ngo, Vladimir Yarov-Yarovoy, Igor V. Vorobyov, Nipavan Chiamvimonvat 2206-Pos Board B400 PROBE THE MOLECULAR MECHANISM OF BK CHANNELOPATHIES. Yuyin Wang , Guohui Zhang, Augustus Lowry, Audrey K.S. Soo, Jingyi Shi, Lu Han, Borui ZHANG, Manju Kurian, Mohamad Mikati, Huanghe Yang, Jianmin Cui 2207-Pos Board B401 A HIGH-THROUGHPUT SCREEN TO IDENTIFY MODIFIERS OF KCNQ1 TRAFFICKING. Katherine R. Clowes , Mason C. Wilkinson, Carlos G. Vanoye, Katherine M. Stefanski, Kathryn R. Brewer, Alfred L. George, Charles R. Sanders 2208-Pos Board B402 CRYOEM-BASED DISCOVERY OF ALLOSTERIC MODULATORS OF HUMAN BESTROPHIN CHANNELS. Aaron P. Owji , Jingyun Dong, Alec Kittredge, Jiali Wang, Yu Zhang, Tingting Yang 2209-Pos Board B403 RESCUING AUTOMATED PATCH CLAMP ASSAY ON LOW EXPRESSING K V 1.3 CELL LINE USING FLUORESCENCE-BASED CELL SORTING. Arianna Toppi, David Nagy , Beatrice Badone, Kim Boddum 2210-Pos Board B404 THE EFFECTS OF SALT ON DIASTOLIC DYSFUNCTION AND ELECTROPHYSI OLOGICAL REMODELING INDUCED BY HYPERCHOLESTEROLEMIA. Liyang Zhang , Xiao Liu, K. Taiga Andersson, Anxhela Kote, James E Tisdale, Zhenhui Chen, Thomas H. Everett, IV, Xiaochun Li, Michael C. Fishbein, Joshua I. Goldhaber, Peng-Sheng Chen 2211-Pos Board B405 CHARACTERIZATION OF A NOVEL NAV1.5 MUTATION IN BRUGADA SYNDROME. Tibor G. Szanto, Szabolcs M. Gaal, Beata Meszaros, Istvan Balogh, Balint L. Balint, Zoltan Csanadi, Gyorgy Panyi Brohawn 2202-Pos

2212-Pos Board B406 C6 AMELIORATES PSEUDOMONAS AERUGINOSA-INDUCED ACUTE LUNG INJURY BY INHIBITING HV1 CHANNELS AND NEUTROPHIL MIGRA TION. Punyanuch Sophanpanichkul , Ruiming Zhao, Benjamin Lopez, Nairrita Majumder, Andreas Schwingshackl, Steve A. Goldstein 2213-Pos Board B407 Travel Award Winner ENGINEERING NANOBODY-BASED MODULATORS FOR TARGETED DOWNREGULATION OF THE SODIUM-LEAK CHANNEL NALCN. Allen L. Hsu , Manu Ben-Johny 2214-Pos Board B408 FUNCTIONAL CHARACTERIZATION OF GRIN2B VARIANTS USING AUTO MATED PATCH CLAMP TECHNOLOGY. Mehwish Akram , Christina Kadi, Eleanor Parker, Claire Brown, Laura Pisarek, Simon Rice, Rosario Finoc chiaro, Sian Morrison, David Dalrymple, Ian McPhee, Robert Macnair, Michael Panzara, Stephen F. Traynelis, Davide Pau, Laura Hutchison 2215-Pos Board B409 FUNCTIONAL CONSEQUENCES OF SULFONYLUREA RECEPTOR ALPHA HELIX PROLINE MUTATIONS IN K ATP CHANNELS. Ellen T. Thompson , Jian Gao, Sun Joo Lee, Colin G. Nichols 2216-Pos Board B410 LEVERAGING DEEP LEARNING TOOLS TO DESIGN HASIC1A MINIPRO TEIN MODULATORS FOR STROKE TREATMENT. Janina Sörmann , Samuel Usher, Fabian Hink, Joseph Rogers, Stephan A. Pless 2217-Pos Board B411 A RYANODINE RECEPTOR GAIN-OF-FUNCTION MUTATION THAT ENTERS THE CLINICAL SPECTRUM IN A HOMOZYGOUS BACKGROUND. Daniel J. Zhu , Wenxuan Cai, Argelia Medeiros-Domingo, Hector H. Valdivia, Car men R. Valdivia 2218-Pos Board B412 CARNOSIC ACID OPENS THE KV1.1 POTASSIUM CHANNELS TO RESCUE EPISODIC ATAXIA TYPE 1 MUTANTS. Hanh A. Nguyen , Rian W. Manville, Geoffrey Abbott 2219-Pos Board B413 GIRK2 DRUG REPURPOSING SCREEN IDENTIFIES TREATMENT OPTIONS FOR PATIENTS SUFFERING FROM EXTREMELY RARE DISEASES. Michael A. Netzer , Steffen Hering, Nathan Dascal, Anna Stary-Weinzinger 2220-Pos Board B414 SUBSTRATE SELECTIVITY IN FORMATE/NITRITE TRANSPORTERS (FNT): POSSIBLE PROTONATION STATE OF HIGHLY CONSERVED CENTRAL HISTI DINE. Himanshi Singh 2221-Pos Board B415 HCN-SPECIFIC NANOBODIES FOR THE MODULATION OF PATHOGENIC CHANNELS. Roberta Castelli , Atiyeh Sadat Sharifzadeh, Alessandro Porro, Luca M. G. Palloni, Pietro Mesirca, Matteo Mangoni, Dario DiFran cesco, Gerhard Thiel, Bina Santoro, andrea saponaro, Anna Moroni 2222-Pos Board B416 EXAMINING HCN1 BINDING TO NORQUETIAPINE, AN ACTIVE METABO LITE OF THE ATYPICAL ANTI-PSYCHOTIC DRUG QUETIAPINE. Amelie Jean Jacques , Nazzareno D’Avanzo 2223-Pos Board B417 IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF ANTINO CICEPTIVE ALPHA9ALPHA10 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS. Kyle M. Kremiller, Gauri C. Kulkarni, Hirushi T. Gunas ekara Kalu Arachchige, Yavnika Kashyap, Giokdjen Ilktach, Ying Hu, Zaijie J. Wang, Andrew P. Riley, Christian J. Peters

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