BPS2025 Full Program

Smooth Muscle and Cardiac Muscle Regulation (Boards B418 - B428) 2224-Pos Board B418 TOXIC COMPETITORS OF PHOSPHOLAMBAN MAY CONTRIBUTE TO DYSREGULATION OF SERCA IN HEART FAILURE. Taylor A. Phillips , Jacob D. Cunningham, Jaroslava Seflova, Ellen E. Cho, Seby Edassery, Jonathan A. Kirk, Seth L. Robia 2225-Pos Board B419 ATP DIRECTLY ACTIVATES THICK FILAMENTS IN PORCINE MYOCAR DIUM. Marcus Rhodehamel, Meihua Guo, Vivek P. Jani, Shengyao Yuan, Weikang Ma 2226-Pos Board B420 METHYLGLYOXAL GLYCATION COMPETES WITH UBIQUITINATION, DIS RUPTING SARCOMERE FUNCTION. Christine E. Delligatti , Michaela M. Door, Maria Papadaki, Thomas Martin, Alexandra Peña, Henry M. Gong, Henry Valle-Ayala, Seby Edassery, Leslie A. Leinwand, Weikang Ma, Thomas C. Irving, David Y. Barefield, Jonathan A. Kirk 2227-Pos Board B421 MACHINE LEARNING MODEL OF CROSS-BRIDGE CYCLING IN CARDIAC MUSCLE CONTRACTION. Yasser Aboelkassem 2228-Pos Board B422 SMALL MOLECULES TARGETING THE THIN FILAMENT MODULATE CALCIUM SENSITIVITY AND REVERSE CARDIOMYOPATHY MOTILITY PHE NOTYPES. Meaghan E. Barry , Michael J. Rynkiewicz, Lauren E. Brown, Aaron B. Beeler, Jeffrey R. Moore, William Lehman, Balajee Ramachan dran 2229-Pos Board B423 CARDIOMYOCYTE DELIVERY AND THERAPEUTIC EFFECT OF THE C TERMINAL PEPTIDE OF CARDIAC TROPONIN I. Qiaobin Li 2230-Pos Board B424 INCREASING GLU CONTENTS IN THE N-TERMINAL HYPERVARIABLE REGION OF CARDIAC TROPONIN T PRODUCES A HFPEF-LIKE PHENO TYPE. Han-Zhong Feng , J.-P. Jin 2231-Pos Board B425 INFILTRATIVE CARDIOMYOPATHIES DISPLAY DECREASED PHOSPHORYLA TION OF THICK AND THIN FILAMENT REGULATORY PROTEINS. Florence D. Mumbi , Aidan Gauthier, Noor Eqal, Austin G. Wellette-Hunsucker, Gregory Milburn, Utku Gulbulak, Kenneth S. Campbell 2232-Pos Board B426 SARCOMERIC PROTEINS HAVE DECREASED PHOSPHORYLATION IN HU MAN HEART FAILURE. Austin G. Wellette-Hunsucker , Gregory Milburn, Utku Gulbulak, Aidan C. Gauthier, Florence D. Mumbi, Kenneth S. Board B427 REGULATORY LIGHT CHAIN PHOSPHORYLATION ACTIVATES THE ‘BLOCKED HEAD’ OF CARDIAC MYOSIN. Thomas Kampourakis 2234-Pos Board B428 PROTEIN TYROSINE PHOSPHATASE 1B DIRECTS SARCOMERE LOCALIZA TION OF GLYCOGEN SYNTHASE KINASE 3Β. Michaela M. Door , Laura A. Sherer, Yan Sun, Marisa J. Stachowski, Christine E. Delligatti, Jonathan A. Kirk, Maria Kontaridis Campbell 2233-Pos

Actin Structure, Dynamics, and Associated Proteins (Boards B429 - B441) 2235-Pos Board B429 SINGLE MOLECULE IMAGING REVEALS C. ELEGANS TETRATHYMOSIN BETA’S EFFECT ON ACTIN ASSEMBLY. Sarah M. Christensen , Hannah Ye, Rachel Kadzik, Cristian Suarez, David Kovar, Allison Squires 2236-Pos Board B430 Travel Award Winner NMR-GUIDED LOCALIZATION OF LEIOMODIN-2’S C-TERMINAL ACTIN BINDING SITES. Madison I. Little , Mason D. Summers, Robert Young, John Cort, Alla S. Kostyukova 2237-Pos Board B431 COFILIN’S ROLE IN THE GROWTH OF CYTOSKELETON. Mengxin Gu 2238-Pos Board B432 CHALLENGING PDB STRUCTURES: COMPUTATIONAL INSIGHTS INTO COFILIN OLIGOMERS AND ACTIN REGULATION. Chengxuan Li, Ting-Yi Wei, Margaret S. Cheung, Min-Yeh Tsai 2239-Pos Board B433 THE STATES OF CAPPING PROTEIN ARE DEFINED BY THE STALK. Chenbo Yan , David Sept 2240-Pos Board B434 STEADY STATE ACTIN FILAMENTS UNDERGO ATP-DEPENDENT, BARBED END LENGTH FLUCTUATIONS. Madhura Duttagupta , Andrew T. Riley, William Brieher 2241-Pos Board B435 COMPUTATIONAL SIMULATION OF ASTRAL CYTOSKELETAL NETWORKS REVEALS OPTIMAL ARCHITECTURE FOR MECHANICAL STRENGTH. Brady Berg , Jun F. Allard 2242-Pos Board B436 ADVANCED MODELING OF CYTOSKELETAL DYNAMICS USING MEDYAN. JL. Nathan Zimmerberg , Garegin A. Papoian 2243-Pos Board B437 STUDYING ACTIN-MEMBRANE COUPLED SYSTEMS INSIDE PROTOCELLS AT HIGH HYDROSTATIC PRESSURES. Ayesha Abha Amin , Thomas R. Shaw, Stephen A. Sarles 2244-Pos Board B438 OPTICAL CONTROL OF ACTIN POLYMERIZATION ON THE SUPPORTED LIPID BILAYER. Kei Yamamoto , Makito Miyazaki 2245-Pos Board B439 MOLECULAR MECHANISM OF ACTIN FILAMENT STIFFENING BY CAT IONS. Xiao-Ping Xu, Wenxiang Cao, Charles V. Sindelar, Enrique M. De La Cruz, Niels Volkmann, Dorit Hanein 2246-Pos Board B440 EXPLORING ISOFORM DEPENDENT ARP2/3 STRUCTURAL FLEXIBILITY THROUGH CRYO-EM. Alana R. Cowell , Ramteen Shayan, Miroslav Mlad enov, Michael Way, Carolyn A. Moores 2247-Pos Board B441 CONFINEMENT OF ACTIN WITHIN VASP DROPLETS PROMOTES ACTIN RING FORMATION AND DRIVES DROPLET SHAPE CHANGE. Aravind Chandrasekaran , Kristin Graham, Aly Ladak, Liping Wang, Eileen M. Lafer, Jeanne C. Stachowiak, Padmini Rangamani

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