BPS2025 Full Program

Platform Protein Aggregates 8:15 am - 10:15 am, Room 502B

Platform Neuroscience: Models to Mechanisms 8:15 am - 10:15 am, Room 501ABC

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Co-Chairs Michael Blinov, University of Connecticut School of Medicine, USA Irina Ritsch, Scripps Research, USA 2437-Plat 8:15 am DIGITAL SEED AMPLIFICATION QUANTIFIES THE INCREASE IN SEEDING COMPETENT AGGREGATES IN PARKINSON’S PATIENTS CSF. Aviad Levin , Shenglin Cai, Hannes Ausserwoeger, Georg Meisl, Daoyuan Qian, Rob Scrutton, Irina A. Edu, Georg Krainer, Tomas Sneideris, Lin Chai, William Arter, Tuomas P. Knowles 2438-Plat 8:30 am TRANSTHYRETIN AGGREGATION IN FLUID FLOW - A STRUCTURAL PER SPECTIVE. Irina Ritsch , Peter E. Wright, Jane Dyson 2439-Plat 8:45 am THE INFLUENCE OF HEAVY METALS ON THE FORMATION OF OLIGOMER IC FORMS OF HUMAN CYSTATIN C. Daria Wojciechowska , Arkadiusz Taras, Michal Taube, Zuzanna Pietralik-Molinska, Joanna Wolak, Maciej Kozak 2440-Plat 9:00 am SPRINGSALADPY: PYTHON-BASED ANALYSIS AND VISUALIZATION OF MOLECULAR CLUSTERS IN 3D. Harrison L. Perone, Aniruddha Chattaraj, Michael L. Blinov 2441-Plat 9:15 am INFERENCE FOR FIBRIL TOPOLOGY USING NETWORK HAMILTONIAN MODELS. Zixiao Zong, Elizabeth M. Diessner, Carter T. Butts 2442-Plat 9:30 am UNDERSTANDING PROTEIN SELF-ASSEMBLY USING AN INTEGRATIVE ANTIBODY-DISCOVERY APPROACH. Devkee M. Vadukul, Dimitra Gi alama, Ying Ge, Rebecca J. Thrush, Giacomo Corucci, Sheena E. Radford, Francesco A. Aprile 2443-Plat 9:45 am LIVE CELL IMAGING OF INFLAMMATION INDUCED BY PROTEIN AGGRE GATES. Arpan Dey , Yuhao Cui, Joseph P. Boyle, Prasanna Suresh, Clare Bryant, David Klenerman 2444-FlashTalk 10:00 am FLAT CLATHRIN LATTICES RESULT FROM KINETIC TRAPPING IN RE SPONSE TO GROWTH FACTOR STIMULUS. Lingxia Qiao , Marco Alfonzo Mendez, Justin W. Taraska, Padmini Rangamani 2445-FlashTalk 10:05 am DECOUPLING THE ROLE OF DNA ON MUTANT P53 AGGREGATION. Matthew Steinsaltz , Zachary A. Levine 2446-FlashTalk 10:10 am QUANTITATIVE BOND-SELECTIVE IMAGING OF POLYQ AGGREGATES WITHOUT EGFP LABELING REVEALS AGGREGATION COMPARTMENTAL IZATION AND GROWTH DYNAMICS IN LIVE NEURONS. Xiaotian Bi , Li-En Lin, Lu Wei

Co-Chairs Joao Carvalho-de-Souz, Midwestern University, USA Xuelin Lou, Medical College of Wisconsin, USA 2447-Plat 8:15 am

EVALUATION OF DISEASE PHENOTYPES IN HIPSC-DERIVED NEURONS USING AUTOMATED PATCH CLAMP. Stefania Karatsiompani, Scott Schachtele, Kadla R. Rosholm 2448-Plat 8:30 am IN VIVO DRUG SCREENING OF ZEBRAFISH BRAIN ACTIVITY IDENTIFIES POTENTIAL TARGETS FOR EPILEPSY AND PAIN. Richard Kanyo , Ethan Smith, W. Ted Allison, Harley T. Kurata 2449-Plat 8:45 am SARM1 FUNCTION IN AMYLOID-Β-INDUCED SYNAPSE DEGENERATION IN ALZHEIMER’S DISEASE. Fan Fan, Prince Joshi, Xiaojie Liu, Sandeep Kotturu, Qingsong Liu, Xuelin Lou 2450-Plat 9:00 am DENDRITIC TARGETING OF SPINOCEREBELLAR ATAXIA-RELATED ION CHANNELS IN CEREBELLAR PURKINJE NEURONS REQUIRES A MICROTU BULE STABILIZING PROTEIN. Di Ma, Nanditha Nalinakshan , Chao Sun, Peter Jukkola, Chen Gu 2451-Plat 9:15 am CURVATURE MATRIX SPATIAL-TEMPORALLY PRIMES EPIGENETIC STATE FOR ENHANCED CELL REPROGRAMMING EFFICIENCY AND SUBTYPE DIVERSIFICATION. Yang Song 707-Pos 9:30 am Replacement Presenter THE APPROACH OF MULTI-SCALE MODELING FOR UNDERSTAND ING AND ADDRESSING THE PATHOGENESIS OF MULTIPLE SCLERO SIS. Vailankanni L. Rodrigues , Dr. Gregory L. Dignon 2453-Plat 9:45 am GOLD NANOPARTICLE-ASSISTED OPTOCAPACITANCE ENHANCES RETI NAL PHOTOSENSITIVITY. Diego S. Souza, Samer Hattar, James Delehanty, Joao L. Carvalho-de-Souza 2454-FlashTalk 10:00 am MOLECULAR MECHANISMS OF FLUORESCENT PROTEIN SENSORS RESPONSE TO LIGAND BINDING: FROM CONFORMATIONAL DISPLACE MENTS TO ELECTROSTATIC REDISTRIBUTION TO SPIKE IN FLUORES CENCE. Mikhail Drobizhev , Rosana S. Molina 2455-FlashTalk 10:05 am HUMAN ASTROCYTE CALCIUM SIGNALING IN A CEREBRAL ORGANOID. Kaitlin Szederkenyi , Liliana Attisano, Martin Oheim, Christopher M. Yip 2456-FlashTalk 10:10 am AGING OF Α-SYNUCLEIN CONDENSATES WITH AGGREGATION. Lin Chai

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