BPS2025 Full Program

2867-Pos Travel Award Winner CHARACTERIZATION OF SEVEN NEW K + CHANNEL BLOCKER PEPTIDES OF CENTRUROIDES BONITO REVEALED Α-KTX 2.24 HAS A PICOMOLAR AFFINITY FOR KV1.2. Kashmala Shakeel , Timoteo Olamendi-Portugal, Muhammad Umair Naseem, Baltazar Becerril, Fernando Z. Zamudio, Gustavo Delgado-Prudencio, Lourival Domingos Possani, Gyorgy Panyi 2868-Pos Board B332 A KEY RESIDUE IN S4-S5 LINKER CONTROLS ELECTROMECHANICAL COUPLING IN KV CHANNELS. Yichen Liu , Carlos Alberto Z. Bassetto Jr, Gustavo F. Contreras, Eduardo Perozo, Francisco Bezanilla 2869-Pos Board B333 UNDERSTANDING THE ROLE OF SILENT SUBUNITS IN CONCATENATED HETEROMERIC KV2.1/KV6.4 CHANNELS. Debanjan Tewari, Christian Sattler , Klaus Benndorf 2870-Pos Board B334 STUDYING THE INTERACTION OF K V 1.3-SPECIFIC INHIBITORS WITH K V 1.3-K V 1.X HETEROTETRAMERIC ION CHANNELS. Muhammad Umair Naseem , Amna S. Al Olaimi, Dorothy C.C. Wai, Michael W. Pennington, Raymond S. Norton, Gyorgy Panyi 2871-Pos Board B335 MCHERRY-VM24: A FLUORESCENT LIGAND FOR THE STUDY OF THE VOLTAGE-GATED POTASSIUM CHANNEL KV1.3. Jesús A. Borrego Terrazas , Muhammad Umair Naseem, Amna S. Al Olaimi, Éva Korpos, Árpád Szöőr, Gyula Batta, Attila Gáspar, Dávid Ruben Szabó, Zoltan Varga, Gyorgy Panyi 2872-Pos Board B336 ROLE OF THE DIVERGENT C-TERMINAL DOMAINS IN SUBTLE FUNC TIONAL DIFFERENCES IN MEMBERS OF THE KV2 FAMILY OF POTASSIUM CHANNELS. Shreyas Bhat , Deniz Özaydın, Juliane Deroy-Gagnon, Rikard Blunck 2873-Pos Board B337 THE ROLE OF K CHANNELS IN FEATHER BUD MORPHOGENESIS. Robert H. Chow , Madison Zitting, Zhou Yu, Chih-Kuan Chen, Randall Widelitz, Chuong Cheng-Ming 2874-Pos Board B338 OFF-TARGET EFFECTS OF PIEZO1 AGONISTS ON MACROPHAGES. Hai M. Nguyen , Kyan Huang, Yanjun Cui, Heesung Shim, Heike Wulff 2875-Pos Board B339 MOLECULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF CUTANEOUS SCHWANN CELLS. Maia Moog , Angela Ballesteros, Patrik Ernfors, Kenton Swartz 2876-Pos Board B340 SELECTIVITY AND RESOLVATION OF THE ION IN THE K+ CHANNEL: THE CAVITY AND CONSERVATION OF THE THREONINES AT THE SELECTIVITY FILTER ENTRANCE: FOUR HYDROXYL GROUPS ARE CRITICAL. Alisher M. Kariev , Michael E. Green 2877-Pos Board B341 THERMODYNAMIC BAYESIAN MODELING OF VOLTAGE-GATED POTAS SIUM CHANNELS. Samuel Poitras , Rose Champoux, Rikard Blunck 2878-Pos Board B342 CONDUCTION AND SELECTIVITY MECHANISM OF ION CHANNELS USING QUANTUM MECHANICS. Cole Allen , Susan L. Rempe, Mark J. Stevens, Pengyu Ren 2879-Pos Board B343 EXPLORING CATION PAIRING AND PERMEATION MECHANISMS IN PO TASSIUM CHANNELS USING MOLECULAR DYNAMICS SIMULATIONS AND POLARIZABLE FORCE FIELDS. Taylor E. Short , Toby W. Allen Board B331

2880-Pos Board B344 BRIDGING EQUILIBRIUM AND NON-EQUILIBRIUM DYNAMICS: UNRAV ELING PROTEIN FUNCTION THROUGH MULTISCALE RESPONSIVE KINETIC MODELING. Hannah Weckel-Dahman , Jessica M. Swanson 2881-Pos Board B345 MICROSCALE THERMOPHORESIS: A POWERFUL METHODOLOGY TO MEASURE POTASSIUM CHANNELS ION BINDING SITES DISSOCIATION CONSTANTS. Megan M. Skains , Samantha Stanfield, D. Marien Cortes, Luis G. Cuello 2882-Pos Board B346 ION DEHYDRATION IN THE GATING OF POTASSIUM ION CHANNELS, AND A PARADOX. Alisher M. Kariev, Michael E. Green Membrane Pumps, Transporters, and Exchangers II (Boards B347 - B356) 2883-Pos Board B347 CAPTURING THE STRUCTURAL DYNAMICS AND ENERGETICS OF THE LARGE-SCALE ELEVATOR TRANSITION OF NACT. Noah Trebesch , Emad Tajkhorshid 2884-Pos Board B348 GLUTATHIONE TRANSPORT THROUGH THE MALARIA PARASITE’S CHLO ROQUINE RESISTANCE TRANSPORTER, PFCRT. Eva Gil-Iturbe , Jonathan Kim, Laura M. Hagenah, Filippo Mancia, David A. Fidock, Matthias Quick 2885-Pos Board B349 STRUCTURAL AND MOLECULAR BASIS OF CHOLINE UPTAKE INTO THE BRAIN BY FLVCR2. Rosemary J. Cater , Dibyanti Mukherjee, Thomas Arnold, Filippo Mancia 2886-Pos Board B350 FROM SEQUENCE TO MECHANISM: PROBING THE ALTERNATING-AC CESS CYCLE OF CYSTINOSIN WITH ENHANCED-SAMPLING MOLECULAR DYNAMICS AND QM/MM SIMULATIONS. Jonathan D. Colburn , Simon Newstead, Philip C. Biggin 2887-Pos Board B351 THE INHIBITION MECHANISM OF URATE TRANSPORTER URAT1 BY GOUT DRUGS. Justin G. Fedor , Yang Suo, Han Zhang, Kalina Tsolova, Ziaoyu Shi, KEDAR SHARMA, Shweta Kumari, Mario J. Borgnia, Peng Zhan, Wonpil Im, Seok-Yong Lee 2888-Pos Board B352 TRANSPORTER DE-OLIGOMERIZATION REGULATES COPPER UPTAKE INTO HUMAN CELLS. Tai-Yen Chen 2889-Pos Board B353 STRUCTURAL DETERMINANTS OF CLC-7 VOLTAGE DEPENDENCE, GAT ING, AND CHLORIDE/PROTON COUPLING. Jacob K. Hilton , Yifei Lin, Jus tin Deme, Joanne Parker, Michael Grabe, Susan Lea, Simon Newstead, Joseph A. Mindell 2890-Pos Board B354 MAGNESIUM TRANSPORTER MGTA REVEALED AS A DIMERIC P-TYPE ATPASE. Rilee Zeinert, Fei Zhou, Pedro Franco, Jonathan Zöller, Zaid K. Madni, Henry J. Lessen, Aravind Iyer, Julian Langer, Alexander J. Sodt, Gisela Storz, Doreen Matthies 2891-Pos Board B355 PHARMACOLOGY OF THE MAMMALIAN BRAIN V-ATPASE STUDIED AT THE SINGLE MOLECULE LEVEL IN INTACT SYNAPTIC VESICLES. Eleftherios I. Kosmidis, Maria Fokaeos

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