BPS2025 Full Program

Postdoctoral Breakfast 7:30 am - 8:30 am, Room 403B

32-Symp 9:05 am CONFORMATION CHANGES GOVERN ASSEMBLY AND CONSTRICTION OF THE MITOCHONDRIAL FISSION PROTEIN, DRP1. Jason A. Mears 33-SympSelect 9:30 am PRINCIPLE OF COTRANSLATIONAL PROTEIN TARGETING TO MITOCHON DRIA. Shu-ou Shan No Abstract 8:15 am MOLECULAR MECHANISMS OF MITOCHONDRIAL THERMOGENESIS. Yuriy Kirichok Platform Ion Channels, Pharmacology, and Disease 8:15 am - 10:15 am, Room 515A Co-Chairs LEVERAGING DEEP LEARNING TOOLS TO DESIGN HASIC1A MINIPROTEIN MODULATORS FOR STROKE TREATMENT. Janina Sörmann , Samuel Usher, Fabian Hink, Joseph Rogers, Stephan A. Pless 35-Plat 8:30 am IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF ANTINO CICEPTIVE ALPHA9ALPHA10 NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS. Kyle M. Kremiller, Gauri C. Kulkarni, Hirushi T. Gunas ekara Kalu Arachchige, Yavnika Kashyap, Giokdjen Ilktach, Ying Hu, Zaijie J. Wang, Andrew P. Riley, Christian J. Peters 36-Plat 8:45 am HCN-SPECIFIC NANOBODIES FOR THE MODULATION OF PATHOGENIC CHANNELS. Roberta Castelli , Atiyeh Sadat Sharifzadeh, Alessandro Porro, Luca M. G. Palloni, Pietro Mesirca, Matteo Mangoni, Dario DiFran cesco, Gerhard Thiel, Bina Santoro, andrea saponaro, Anna Moroni 37-Plat 9:00 am ION CHANNEL INHIBITION BY TARGETED RECRUITMENT OF NEDD4-2 WITH DIVALENT NANOBODIES. Emmanuel Afriyie , Travis J. Morgen stern, Arden Darko-Boateng, Sri Karthika Shanmugam, Papiya Choud hury, Robert S. Kass, Oliver B. Clarke, Henry M. Colecraft 38-Plat 9:15 am GIRK2 DRUG REPURPOSING SCREEN IDENTIFIES TREATMENT OPTIONS FOR PATIENTS SUFFERING FROM EXTREMELY RARE DISEASES. Michael A. Netzer , Steffen Hering, Nathan Dascal, Anna Stary-Weinzinger 39-Plat 9:30 am EXAMINING HCN1 BINDING TO NORQUETIAPINE, AN ACTIVE METABO LITE OF THE ATYPICAL ANTI-PSYCHOTIC DRUG QUETIAPINE. Amelie Jean Jacques , Nazzareno D’Avanzo 40-Plat 9:45 am CRYO-EM REVEALS BINDING AND ACTIVATION OF THE RYANODINE RE CEPTOR BY MULTIPLE STATIN MOLECULES. Steven Molinarolo , Carmen R. Valdivia, Hector H. Valdivia, Filip Van Petegem 41-FlashTalk 10:00 am Travel Award Winner SUBSTRATE SELECTIVITY IN FORMATE/NITRITE TRANSPORTERS (FNT): POSSIBLE PROTONATION STATE OF HIGHLY CONSERVED CENTRAL HISTI DINE. Himanshi Singh 42-FlashTalk 10:05 am A RYANODINE RECEPTOR GAIN-OF-FUNCTION MUTATION THAT ENTERS THE CLINICAL SPECTRUM IN A HOMOZYGOUS BACKGROUND. Daniel J. Zhu , Wenxuan Cai, Argelia Medeiros-Domingo, Hector H. Valdivia, Car men R. Valdivia Katherine Clowes, Vanderbilt University, USA Gyorgy Panyi, University of Debrecen, Hungary 34-Plat 8:15 am

F R I D A Y

S U N D A Y

Being a postdoc is not easy and there can be many challenges along the way. This breakfast presents an opportunity for postdoctoral Annual Meeting attendees to meet and discuss the issues they face in their cur rent career stage. Attendees will have the opportunity to hear and learn from speakers who will share their journeys, experiences, and success stories. Limited to the first 100 attendees. Moderators Christian Jorgensen, Portsmouth University, United Kingdom Registration/Exhibitor Registration 7:30 am - 5:00 pm, West Lobby Poster Viewing 8:00 am - 10:00 pm, West Exhibit Hall Symposium Massive Quantitative Proteome-Wide Biophysics 8:15 am - 10:15 am, Petree Hall C Chair Sina Ghaemmaghami, University of Rochester, USA 25-Symp 8:15 am BEYOND THE BIOLOGICAL SEQUENCE SPACE, TOWARDS ARTIFICIAL PROTEINS. Klará Hlouchová , Filip Buchel, Tereza Neuwirthova 26-Symp 8:40 am SINGLE-MOLECULE STRUCTURAL AND KINETIC STUDIES ACROSS SE QUENCE SPACE. John Van Noort 27-Symp 9:05 am DECIPHERING THE TMEM16F-DEPENDENT EXTRACELLULARLY EXPOSED PROTEOME WITH SLAPSHOT. Chin Fen Teo 28-SympSelect 9:30 am MASSIVELY MULTIPLEXED SINGLE-MOLECULE FLUORESCENCE MICROS COPY. Sebastian Deindl 29-Symp 9:50 am GLOBAL ANALYSIS OF PROTEIN FOLDING STABILITIES. Sina Ghaemmaghami Symposium Mitochondrial Dynamics and Regulation in Health and Disease 8:15 am - 10:15 am, Petree Hall D Chair Yuriy Kirichok, University of California, San Francisco, USA 30-Symp 8:15 am MITOCHONDRIA AS SIGNALING PLATFORMS: THE ROLE OF THE OUTER AND INNER MITOCHONDRIAL MEMBRANE. Verian Bader, Apurva Saha, Zhixiao Wu, Maria Georgina Herrera, Jörg Tatzelt, Konstanze F. Winklhofer 31-Symp 8:40 am STRUCTURAL MAPPING OF MITOCHONDRIAL CO-TRANSLATIONAL IMPORT IN CELLS. Danielle A. Grotjahn , Ya-Ting Chang, Benjamin A. Barad, Hamidreza Rahmani, Brian M. Zid Trushar Patel, University of Lethbridge, Canada Dylan Girodat, University of Lethbridge, Canada

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