BPS2025 Full Program

Platform Protein Structure and Conformation I 8:15 am - 10:15 am, Room 502A

43-FlashTalk 10:10 am CARNOSIC ACID OPENS THE KV1.1 POTASSIUM CHANNELS TO RESCUE EPISODIC ATAXIA TYPE 1 MUTANTS. Hanh A. Nguyen , Rian W. Manville, Geoffrey Abbott Platform Optical Microscopy and Superresolution Imaging I 8:15 am - 10:15 am, Room 515B Co-Chairs Elizabeth Hinde, University of Melbourne, Australia Xiaoyu Shi, University of California, Irvine, USA 44-Plat 8:15 am SINGLE-MOLECULE LIVE IMAGING OF ENDOGENOUS PROTEIN INTERAC TIONS USING PROXIMITY-ASSISTED PHOTOACTIVATION (PAPA). Thomas G.W. Graham 45-Plat 8:30 am UNVEILING SUBNUCLEAR LOCALIZATION OF DNA DAMAGE PATTERNS THROUGH QUANTITATIVE ANALYSIS OF A DNA COUNTERSTAIN. Greta Paterno , Elisa Longo, Silvia Scalisi, Luca Lanzano’ 46-Plat 8:45 am DNA BASE-STACKING ENABLES PROTEIN PROXIMITY DETECTION AND MULTIPLEXED SUPER-RESOLUTION IMAGING. Abhinav Banerjee , Vedanth Shree Vidwath, Micky Anand, Mahipal Ganji 47-Plat 9:00 am TAGGING PROTEINS FOR LIVE-CELL SUPER-RESOLUTION IMAGING. Haresh Bhaskar , Mathew H. Horrocks, Lynne J. Regan, Sonia Gandhi 48-Plat 9:15 am PAIR CORRELATION MICROSCOPY OF HETEROTRIMERIC TRANSCRIP TION FACTOR TRANSPORT. Elizabeth Hinde , Julissa Sanchez Velasquez, Xiaomeng Zhang 49-Plat 9:30 am LR-E X M EXPANSION MICROSCOPY UNCOVERS NUCLEAR DEFORMA TION AS A KEY REGULATOR OF RIBOSOME BIOGENESIS. Yinyin Zhuang, Xiangfu Guo, Qingyuan Xia, Qin Na, Yajin Mo, Olga Razorenova, Christo pher Miles, Wenting Zhao, Xiaoyu Shi 50-Plat 9:45 am ELUCIDATING SUBCELLULAR ARCHITECTURE AND DYNAMICS WITH SUPER-RESOLUTION MICROSCOPY. Yongdeng Zhang 51-FlashTalk 10:00 am ACCELERATED SINGLE-OBJECTIVE LIGHT SHEET IMAGING WITH INTE GRATED PROCESSING PIPELINE FOR CEACAM VISUALIZATION. Yanru Xu , Mingyang Liang, Aaron Au, Christopher M. Yip 52-FlashTalk 10:05 am SIMPLE MULTIPLEXED IMMUNOFLUORESCENCE (SIMPL-IF) COUPLED WITH STED MICROSCOPY ENABLES EXPLORATION OF CELLULAR ORGA NIZATION AT SUPER- RESOLUTION. Ryan B. McMillan , Michel Nofal, Gokul Gowri, Ezra Kruzich, Matthew Serrata, Hanquan Su, Kuanwei Sheng, Alexander Pauer, Michael Kirber, Peng Yin 53-FlashTalk 10:10 am MILLISECOND-RESOLUTION CRYO-VITRIFICATION FOR NANOSCALE CELLULAR BIOLOGY. Simon Merminod , Arvind Srinivasan, Yue Sun, Daphne-Eleni Archonta, Ami U. Thakrar, Sohaib Abdul Rehman, Xingchi Yan, Jovan Tormes Vaquerano, Edward Soucy, Sarah M. Sterling, Chris H. Rycroft, Maxim B. Prigozhin

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S U N D A Y

Co-Chairs Hansol Lee, Seoul National University, South Korea Muralikrishna Lella, Duke University, USA 54-Plat 8:15 am

STRUCTURAL AND PHYSICOCHEMICAL ATTRIBUTES OF INTEGRIN BIND ERS THAT SUPPORT ORGANOID GROWTH. Saket R. Bagde , Jing Li, Joost J.A.P.M. Wijnakker, Xuanwei Huang, Jiabin Yan, Joy Huang, Hans Clevers, Timothy A. Springer 55-Plat 8:30 am STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF INTEGRIN ALPHA5-TARGETING ANTIBODIES FOR ANTI-ANGIOGENIC THERAPY. Adam Nguyen , Joel B. Heim, Gabriele Cordara, Matthew C. Chan, Hedda Johannesen, Cristine Charlesworth, Ming Li, Caleigh M. Azumaya, Benja min Madden, Ute Krengel, Alexander Meves, Melody G. Campbell 56-Plat 8:45 am STRUCTURAL INSIGHTS INTO THE MOLECULAR MECHANISM OF BROAD SPECTRUM NEUTRALIZATION OF SARS-COV-2 VARIANTS BY BNABS. Bingjie Tang 57-Plat 9:00 am Travel Award Winner RATIONAL ENGINEERING OF HIV-1 ENV TO ENHANCE RECOGNITION OF FUSION PEPTIDE IN A GLYCAN DEPENDENT MANNER. Bhishem Thakur, Muralikrishna Lella , Xiao Huang, Priyanka Devkota, Victor Ilevbare, Radha D. Adhikari, Katarzyna Janowska, Priyamvada Acharya 58-Plat 9:15 am Travel Award Winner SAME BITS, NEW TRICKS: INVESTIGATING STRUCTURAL AND REGULA TORY DIFFERENCES BETWEEN P-REX RHOGEFS. Lauren K. Anderson , Rohan Marde, Jennifer Cash 59-Plat 9:30 am A CRYPTIC POCKET IN EBOLA VP35 PROTEIN EXHIBITS CONSERVED DYNAMICS AND FUNCTION IN CELL-LIKE CONDITIONS. Prajna Mishra , Gregory R. Bowman 60-Plat 9:45 am CRYO-EM STRUCTURE OF HUMAN DICER IN A CLEAVAGE-READY STATE. Hansol Lee , Soung-Hun Roh 61-FlashTalk 10:00 am PPM1D PHOSPHATASE: CRYSTAL STRUCTURE, MECHANISTIC STUDIES, AND STRUCTURE-BASED VIRTUAL SCREENING. Jay P. Kumar , Dalibor Kosek, Stewart Durell, Nadya I. Tarasova, Lisa Jenkins, Subrata Debnath, Nathan Coussens, Matthew Hall, Daniel Appella, Fred Dyda, Sharlyn Mazur, Ettore Appella 62-FlashTalk 10:05 am LIGAND BINDING INTIATES SINGLE-MOLECULE INTEGRIN CONFORMA TIONAL ACTIVATION. Jing Li 63-FlashTalk 10:10 am STRUCTURE-GUIDED ENGINEERING OF THERMODYNAMICALLY EN HANCED CAS9 FOR EFFICIENT GENE SUPPRESSION. Hyeyeon Jeon, Eun Sung Kang, Dongsun Shin, Do Hyun Bae , Yong Ho Kim

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