BPS2025 Full Program

Platform Intrinsically Disordered Proteins I 8:15 am - 10:15 am, Room 502B

75-Plat 8:30 am ENHANCING CAR-T CELL BINDING TO OVERCOME THE CANCER CELL GLYCOCALYX BARRIER. Sangwoo Park , Marcela V. Maus 76-Plat 8:45 am IDENTIFICATION OF CYANOTOXINS WITH A BIOLOGICAL NANOPORE. Alissa Agerova , Chan Cao, Tamar Kohn, Matteo Dal Peraro 77-Plat 9:00 am UNRAVELING DYNAMIC FEATURES IN AEROLYSIN NANOPORE FOR PRE CISE SINGLE-MOLECULE IDENTIFICATION. Jia Wang , Shao-Chuang Liu, Zheng-Li Hu, Yi-Lun Ying, Yi-Tao Long 78-Plat 9:15 am PROTEIN ENGINEERING PRINCIPLES FOR TARGETING BIOFILMS USING GOLD NANOPARTICLES. Dhanush L. Amarasekara, Tanveer Shaikh, Radha P. Somarathne, Gabriel Alcantara, Madison A. Hejny, Elizabeth R. McCaffrey, Nicholas C. Fitzkee 79-Plat 9:30 am FLIM BIOSENSOR PLATFORM UNVEILS HEAT PRODUCTION AT THE SUBCELLULAR SCALE IN THERMOGENIC CELLS. Satoshi Arai , Kayoko Nomura, Cong Q. VU, Takeru Yamazaki 80-Plat 9:45 am THE POWER OF GOLD: ENHANCING RESONANT PHOTONIC BIOSENSORS FOR ULTRA-SENSITIVE ALZHEIMER BIOMARKER DETECTION. Katie Morris , Guilherme Simoneti de Arruda, Augusto Martins, Serafina Cou pe, Emiliano R. Martins, Steven D. Quinn, Thomas F. Krauss 81-FlashTalk 10:00 am UPCONVERTING MICROGAUGES REVEAL INTRALUMINAL FORCE DYNAMICS IN VIVO . Jason R. Casar , Miriam B. Goodman, Jennifer A. Dionne, Claire A. McLellan, Cindy Shi, Malaya Gaerlan, Ariel Stiber 82-FlashTalk 10:05 am ANTIMICROBIAL POLYLYSINE-PHAGE CONJUGATES FOR IMPROVED BIOCOMPATIBILITY. Shelby Vexler , Casey Morrison, Saumya Jain, Yanxi Yang, Nasim Annabi, Timothy J. Deming, Irene A. Chen 83-FlashTalk 10:10 am SIMULATIONS OF PARTICLE ENGULFMENT BY CELLULAR AGGREGATES. Ronan Tiu, Daniel Nykamp, Horia I. Petrache , Nicanor Moldovan Platform Protein-Lipid Interactions: Structure and Dynamics I 8:15 am - 10:15 am, Room 511ABC Co-Chairs MECHANISM OF LIPID-DEPENDENT COLD SENSITIVITY IN THE CYCLIC NUCLEOTIDE-MODULATED ION CHANNEL STHK. Chieh-Chin Li , Crina M. Nimigean 85-Plat 8:30 am WHAT DETERMINES THE DWELL-TIME OF A BOUND LIPID? INTERPRET ING LIPID DENSITIES IN STRUCTURAL DATA USING MOLECULAR DY NAMICS SIMULATIONS AND SPECIALIZED TOOLS FOR THEIR ANALYSIS. Nathan Bernhardt , Shan Zhang, Robyn Stix, José D. Faraldo-Gómez 86-Plat 8:45 am INTERPLAY BETWEEN LIPIDS AND LIGAND ACTIVATION IN STHK CHAN NELS. Ashley J. Newton, Robert D. Latvala, Philipp A.M. Schmidpeter 87-Plat 9:00 am ALLOSTERIC MODULATION OF ELIC BY POPG AND POPE; DISTINGUISH ING OVERLAPPING PHOSPHOLIPID BINDING MODES USING SAFEP. Ezry Santiago-McRae , Thomas T. Joseph, Wayland W. Cheng, Jerome Henin, Grace H. Brannigan Grace Brannigan, Rutgers University, USA Chieh-Chin Li, Weill Cornell Medicine, USA 84-Plat 8:15 am

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Co-Chairs Dilraj Lama, Karolinska Institute, Sweden Ana Melo, Instituto Superior Técnico (IST), Portugal 64-Plat 8:15 am HEXIM1 HOMODIMER BINDS TWO SITES ON 7SK RNA TO RELEASE AU TOINHIBITION FOR P-TEFB INACTIVATION. Yuan Yang , Maria G. Murrali, Yaqiang Wang, Sabrina Galvan, Nahe Ajjampore, Juli Feigon 65-Plat 8:30 am UNTANGLING THE ROLE OF DISTINCT LIPID COMPOSITIONS IN THE INITIAL MEMBRANE-BINDING OF TAU PROTEIN AT THE SINGLE-MOLE CULE LEVEL. Joana Paixão, Ana Coutinho, Ana Azevedo, Manuel Prieto, Martin Hof, Ana M. Melo 66-Plat 8:45 am DECIPHERING THE DISORDERED INTERACTION OF PROTHYMOSIN Α WITH S100A13. Ketty C. Tamburrini 67-Plat 9:00 am MODULATION OF C-MYC STRUCTURE AND ACTIVITY BY TARGETING A CONFORMATIONAL SWITCH. Thibault Vosselman, Cagla Sahin, Kaare Teilum, David P. Lane, Marie Arsenian-Henriksson, Michael Landreh, Dilraj Lama 68-Plat 9:15 am SINGLE-MOLECULE CONFORMATIONAL COMPLEXITY IN DISORDERED REGIONS OF FUSION ONCOPROTEINS. Debapriya Das , Daniel Scholl, Aaron H. Phillips, Richard Kriwacki, Ashok Deniz 69-Plat 9:30 am MOLECULAR INSIGHTS INTO THE SELF-ASSEMBLY OF ABRI AND ADAN PEPTIDES IN FAMILIAL DEMENTIAS. Zhenzhen Zhang , Feng Ding 70-Plat 9:45 am CAN ALPHAFOLD HELP US REFINE ENSEMBLES OF INTRINSICALLY DISOR DERED PROTEINS ? Vincent Schnapka , Massimiliano Bonomi 71-FlashTalk 10:00 am QUANTIFYING THE CONFORMATIONAL LANDSCAPE OF THE MARGIN ALLY DISORDERED PROTEIN HYPK WITH ATOMIC SIMULATION. Kari Gaalswyk , Kingshuk Ghosh, Martin Gruebele 72-FlashTalk 10:05 am PHYSIOLOGICAL AND PATHOLOGICAL ROLE OF TAU’S PROLINE RICH RE GION IN MICROTUBULE ASSEMBLY. Christopher R. Brue , Karen Acosta, Leland C. Mayne, Elizabeth Rhoades 73-FlashTalk 10:10 am EXPLORING THE FREE ENERGY LANDSCAPE OF PROTEIN-PROTEIN IN TERACTIONS (PPIS) CONTAINING INTRINSICALLY DISORDERED REGIONS (IDRS): A CASE STUDY ON AF9-BCOR COMPLEX IMPLICATED IN LEUKE MIA. Shilpa Sharma , Arjun Saha Platform Co-Chairs Jason Casar, Stanford University, USA Shelby Vexler, University of California, Los Angeles, USA 74-Plat 8:15 am USING SYNHTETIC CELL MODELS TO ELUCIDATE TRANSPORT MECHA NISMS IN BIOLOGICAL SYSTEMS. Ran Tivony , Marcus Fletcher, Ulrich F. Keyser Bioengineering and Biosensors 8:15 am - 10:15 am, Room 501ABC

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