BPS2025 Full Program

Platform Voltage-Gated Channels 10:45 am - 12:45 pm, Room 502B

110-FlashTalk 12:35 pm CHALLENGES IN EQUILIBRIUM SAMPLING FOR ASSESSING COOPERATIV ITY IN A KEY HUB PROTEIN. Shelby D. Santos , Elisar J. Barbar, Daniel M. Zuckerman 111-FlashTalk 12:40 pm CHARGE SCALING IN POTASSIUM CHANNEL SIMULATIONS: CONDUC TANCE, ION OCCUPANCY, VOLTAGE RESPONSE, AND SELECTIVITY. Chenggong Hui , Reinier de Vries, Wojciech Kopec, Bert L. de Groot Platform

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S U N D A Y

Co-Chairs Toby Allen, RMIT University, Australia Zoja Selimi, The Ohio State University, USA 122-Plat 10:45 am

UNRAVELLING THE MECHANISMS OF ION SELECTIVITY IN SODIUM AND SODIUM LEAK CHANNELS. Angelika Janaszkiewicz , Emelie Flood, Celine Boiteux, Han Chow Chua, Stephan A. Pless, Toby W. Allen 123-Plat 11:00 am PREDICTING AND INVESTIGATING GATING PORE CURRENTS IN VOLTAGE SENSOR MUTATIONS OF DOMAIN I IN NA V 1.2 BRAIN SODIUM CHANNEL. Ahmed Eltokhi, Eslam Elhanafy, Jing Li, Tamer M. Gamal El-Din 124-Plat 11:15 am FROM MUTATION TO DYSFUNCTION: EXPLORING THE EFFECT OF NA V 1.5 SELECTIVITY FILTER IN ARRHYTHMIA PATHOGENESIS. Zoja Selimi , Mikhail Tarasov, Xiaolei Meng, Patricia Dias, Bianca Ioana Moise, Renga sayee Veeraraghavan, Przemyslaw Radwanski 125-Plat 11:30 am STAC2 REGULATES THE FUNCTION OF THE NALCN CHANNELOSOME. Peilin Tu, Emma Beyer, Samuel Usher, Britany Rufenach-Barber, Allen L. Hsu, Srinidhi Jayaraman, Filip Van Petegem, Manu Ben-Johny, Stephan A. Pless, Han Chow Chua 126-Plat 11:45 am Travel Award Winner RAD REGULATES CARDIAC CA V 1.2 TRAFFICKING. Maartje Westhoff , Heather C. Spooner, Jonathan Satin, Eamonn J. Dickson, Rose E. Dixon 127-Plat 12:00 pm UTILIZING IPSC MODELS TO UNDERSTAND CACNA1A-RELATED DISOR DERS. Audra A. Kramer , Emma G. Gudmundsson, Kevin G. Herold, Deborah A. DiSilvestre, Joseph R. Mauban, Ivy E. Dick 128-Plat 12:15 pm A DE NOVO DESIGNED MINIPROTEIN PREVENTS CA 2+ -FEEDBACK OF CA V 1 CHANNELS. Marc Yehya , Ryan W. Mahling, Lucile Fossier, Srinidhi Jayaraman, Audrey Lauris Kochiss, Manu Ben-Johny 129-FlashTalk 12:30 pm CHARACTERIZING CCO-TX3 TOXIN BINDING SITE IN NAV1.5 CHANNEL. Erbio Diaz, Janin Riedelsberger, Wendy Gonzalez 130-FlashTalk 12:35 pm SEQUENTIAL CONFORMATIONAL CHANGES DURING FAST INACTIVATION IN VOLTAGE GATED SODIUM CHANNELS. Yichen Liu , Jason D. Galpin, Christopher A. Ahern, Francisco Bezanilla 131-FlashTalk 12:40 pm A HIS BUTTON ON NA V 1.5 MODIFIES ION CHANNEL ACCESSORY PROTEIN INTERACTION AND GATING IN RESPONSE TO CHANGES IN INTRACELLULAR PH. Taylor A. Agee , Garrett M. Knotts, Justin R. Lovett, Spencer K. Lile, Emily M. Campbell, Yusuf Olgar, Christopher N. Johnson

Membrane Protein Structures 10:45 am - 12:45 pm, Room 502A

Co-Chairs Elka Georgieva, Texas Tech University, USA Shiheng Liu, University of California, Los Angeles, USA 112-Plat 10:45 am

BRIDGING THE GAP: THE ROLE OF ENVELOPE-SPANNING HYDROPHOBIC GROOVES IN BACTERIAL PHOSPHOLIPID TRANSPORT. Clare L.A. De’Ath , Georgia L. Isom 113-Plat 11:00 am Travel Award Winner TMEM63C CRYO-EM STRUCTURE INDICATES IT FUNCTIONS AS A MONO MER. Yuqi Qin 114-Plat 11:15 am EVOLUTIONARILY DIVERSE CAVEOLINS SHARE A COMMON STRUCTURAL FRAMEWORK BUILT AROUND AMPHIPATHIC DISCS. Sarah M. Connolly , Bing Han, Louis F.L. Wilson, Tyler S. Brant, Louise Chang, Darrin T. Schultz, Alican Gulsevin, Jens Meiler, Erkan Karakas, Shyamal Mosalaganti, Anne K. Kenworthy, Melanie D. Ohi 115-Plat 11:30 am THE PH DOMAIN IN THE ARFGAP ASAP1 DRIVES CATALYTIC ACTIVATION THROUGH AN UNPRECEDENTED MECHANISM. Olivier Soubias , Samuel Foley, Xiaoying Jian, Rebekah Jackson, Eric Rosenberg, Margaret E. John son, Alexander J. Sodt, Paul Randazzo, Andrew Byrd 116-Plat 11:45 am ALLOSTERIC MECHANISM OF MEMBRANE FUSION ACTIVATION IN A HERPESVIRUS. Gonzalo L. Gonzalez-Del Pino , Richard M. Walsh, Doina Atanasiu, Tina M. Cairns, Wan Ting Saw, Gary H. Cohen, Ekaterina Elina Karimullina , Yirui Guo, Hanif Muhammad Khan, Tabitha Emde, Zbyszek Otwinowski, Peter D. Tieleman, Dominika Borek, Alexei Savchenko 118-Plat 12:15 pm STRUCTURE OF MYCOBACTERIAL NDH-2 BOUND TO 2-MERCAPTO QUINAZOLINONE. Yingke Liang , Stephanie A. Bueler, Chen-yi Cheung, Gregory M. Cook, John Rubinstein 119-FlashTalk 12:30 pm PEPTIDE-BASED DNA MODIFICATIONS FOR FORMATION OF NANODISCS. Praneetha Sundar Prakash , Soumya Chandrasekhar, Thorsten Schmidt 120-FlashTalk 12:35 pm MOLECULAR DYNAMICS SIMULATIONS OF THE LIPID-II INTERACTIONS AND ASSEMBLY OF NISIN CHAINS IN BACTERIAL MEMBRANES. Hugo A. Perez , Bernard S. Gerstman, Prem P. Chapagain 121-FlashTalk 12:40 pm ASYMMETRY OF SINGLE-MOLECULE PARTITIONING AND TRAPPING IN THE AEROLYSIN PORE. Ishan Ghai, Jan C. Behrends Heldwein 117-Plat 12:00 pm NOVEL FINDINGS IN TOLQ-TOLR COMPLEX STRUCTURE.

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