BPS2025 Full Program

Platform Condensates: From Properties to Physiology and Disease I 10:45 am - 12:45 pm, Room 501ABC Co-Chairs Dilimulati Aierken, Princeton University, USA Kalli Kappel, Broad Institute of MIT and Harvard, USA 132-Plat 10:45 am YAP CHARGE PATTERNING MEDIATES SIGNAL INTEGRATION THROUGH TRANSCRIPTIONAL CO-CONDENSATES. Kirstin Meyer , Klaus Yserentant, Rasmi Cheloor-Kovilakam, Kiersten Ruff, Chung Chan-I, Xiaokun Shu, Bo Huang, Orion Weiner 133-Plat 11:00 am EXTRACELLULAR PHASE SEPARATION MEDIATES STORAGE AND RELEASE OF THYROGLOBULIN IN THE THYROID FOLLICULAR LUMEN. Yihan Yao , Nadia Erkamp, Tomas Sneideris, Xiqiao Yang, Rob Scrutton, Matthias M. Schneider, Charlotte M. Fischer, Erik Schoenmakers, Nadia Schoenmak ers, Tuomas Knowles 134-Plat 11:15 am CHARACTERIZING PROTEIN SEQUENCE DETERMINANTS OF NUCLEAR CONDENSATES BY HIGH-THROUGHPUT POOLED IMAGING WITH CON DENSEQ. Kalli Kappel , Daniel Strebinger, KeHuan Kuo Edmonds, Samuel Chau-Duy-Tam Vo, Christopher M. Vockley, Tridib Biswas, Samouil L. Farhi, Rhiannon Macrae, Feng Zhang, Aviv Regev 135-Plat 11:30 am ATOMIC RESOLUTION MAP OF THE SOLVENT INTERACTIONS DRIVING SOD1 UNFOLDING IN CAPRIN1 CONDENSATES. Rashik Ahmed , Ming yang Liang, Rhea P. Hudson, Atul Kaushik Rangadurai, Shuya K. Huang, Julie D. Forman-Kay, Lewis E. Kay 136-Plat 11:45 am REENTRANT PHASE BEHAVIOR AND SELECTIVE PARTITIONING IN PRO TEIN-RNA CONDENSATES USING MOLECULAR DYNAMICS SIMULATION. Ikki Yasuda , Sören Bülow, Giulio Tesei, Eiji Yamamoto, Kenji Yasuoka, Kresten Lindorff-Larsen 137-Plat 12:00 pm MULTISCALE MODELLING OF LIQUID-TO-SOLID TRANSITIONS IN BIO MOLECULAR CONDENSATES. Andres Tejedor, Ignacio Sanchez Burgos, Samuel Blazquez, Jorge Ramirez, Rosana Collepardo-Guevara, Jorge R. 12:15 pm NUCLEAR SPECKLE PROTEINS UNDERGO INTRINSIC AND RNA-DEPEN DENT MICROPHASE SEPARATION. Min Kyung Shinn , Dylan Tomares, Vicky Liu, Yuanxin Qiu, Avnika Pant, Gaurav Chauhan, Matthew R. King, Kiersten Ruff, You Jin Song, Yuna M. Ayala, Gregory W. Strout, Yifan Dai, Matthew D. Lew, Kannanganattu V. Prasanth, Rohit V. Pappu 139-FlashTalk 12:30 pm NONEQUILIBRIUM DYNAMICS AT BIOMOLECULAR CONDENSATE INTER FACES. Yongick Cho, William M. Jacobs 140-FlashTalk 12:35 pm EEFECT OF RNA-RNA INTERACTIONS ON THE MATERIAL PROPERTIES OF BIOMOLECULAR CONDENSATES. Dilimulati Aierken , Vita Zhang, Amy S. Gladfelter, Jerelle A. Joseph, Christine A. Roden 141-FlashTalk 12:40 pm STRUCTURAL AND DYNAMIC PROPERTIES OF TRANSCRIPTION CONDEN SATES AT THE SINGLE MOLECULE LEVEL. Jan-Hendrik Spille Espinosa 138-Plat

Platform DNA Structure and Dynamics 10:45 am - 12:45 pm, Room 511ABC

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Co-Chairs Hemani Chhabra, University of Illinois Urbana-Champaign, USA Isaac Li, University of British Columbia, Canada 142-Plat 10:45 am STRAND STORIES - UNDERSTANDING SSDNA DYNAMICS USING ALL-AT OM MD SIMULATIONS GUIDED VIA HIGH THROUGHPUT FRET. Hemani Chhabra , Sung Hyun Kim, Chirlmin Joo, Aleksei Aksimentiev 143-Plat 11:00 am ENGINEERING DNA-BASED ARTIFICIAL CATCH BONDS. Isaac T.S. Li 144-Plat 11:15 am SIMULATING CHROMOSOME DYNAMICS IN A MINIMAL BACTERIAL CELL. Andrew K. Maytin , Benjamin R. Gilbert, Zane R. Thornburg, Zaida Luthey-Schulten 145-Plat 11:30 am BENDING UNWINDS DNA. Soumya Chandrasekhar, Thomas Swope, Fatemeh Fadaei, Daniel Hollis, Rachel Bricker, Draven Houser, John J. Portman, Thorsten L. Schmidt 146-Plat 11:45 am TRANSCRIPTION-DEPENDENT MOBILITY OF SINGLE GENES AND GENOME-WIDE MOTIONS IN LIVE HUMAN CELLS. Fang-Yi Chu, Alexis S. Clavijo, Suho Lee, Alexandra Zidovska 147-Plat 12:00 pm UNRAVELLING THE EFFECT OF DIVALENT SALT ON THE STRUCTURE OF NEGATIVELY SUPERCOILED DNA. Aleksander Klimczyk, Dorothy Aboagye-Mensah, Graeme A. King 148-Plat 12:15 pm VERTICAL NUCLEIC ACIDS ON GRAPHENE: DYNAMIC STRUCTURAL BIOL OGY WITH ANGSTROM RESOLUTION. Lars Richter 149-FlashTalk 12:30 pm NUCLEOSOME PLACEMENT AND POLYMER MECHANICS EXPLAIN GENOMIC CONTACTS ON 100KBP SCALES. John Corrette , Jiachun Li, Hanjuan Shao, Praveen K. Veerasubramanian, Andrew J. Spakowitz, Timothy L. Downing, Jun F. Allard 150-FlashTalk 12:35 pm SINGLE-MOLECULE BIODOSIMETRY. Michael Lamontagne , Joseph W. Robertson, Michael Zwolak 151-FlashTalk 12:40 pm MECHANISMS FOR SUGAR PUCKERING TO GOVERN RNA-GUIDED DNA SYNTHESIS BY REPAIRING DNA POLYMERASES. Jeanpierre Fuente Undergraduate Student Pizza “Breakfast” 11:30 am - 1:00 pm, Room 403A Connect with other undergraduates at this “breakfast” for a valuable networking and social opportunity. You will also have a chance to meet and talk to Biophysical Society Committee members, and scientists at all career levels to discuss academic goals and questions and learn how to develop a career path in biophysics. Hear from invited speakers who will share their stories and answer questions. Space for this session is limited to the first 100 attendees. Moderators Thayaparan Paramanathan, Bridgewater State University, USA Andrea Ghisleni, IFOM - the FIRC Institute of Molecular Oncology, Italy

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