BPS2025 Full Program

Protein Structure and Conformation I (Boards B1 - B31)

229-Pos Travel Award Winner BEYOND THE CORE: INVESTIGATING HOW ACCESSORY REGIONS OF PDZ RHOGEF REGULATE ITS CATALYTIC CORE IN RHOA ACTIVATION. Matthew V. Braga , Jennifer Cash 230-Pos Board B14 WEAKENED ALLOSTERIC CONSTRAINTS IN THE SMALL GTPASE ARF6 CONTRIBUTE TO FASTER NUCLEOTIDE EXCHANGE THAN IN ARF1. Noam Hantman , Tejaswi Naidu Koduru, Edgar Peters, Scott A. McCallum, Rich ard E. Gillilan, Jacqueline Cherfils, Catherine A. Royer 231-Pos Board B15 ELUCIDATION OF ARF1 REGULATOR SPECIFICITY USING PRESSURE PERTURBATION. Edgar Peters , Tejaswi Naidu Koduru, Noam Hantman, Jacqueline Cherfils, Scott A. McCallum, Qingqiu Hunag, Richard E. Gil lilan, Catherine A. Royer 232-Pos Board B16 STRUCTURAL BASIS FOR REGULATION OF CD36 FUNCTION BY PHOS PHORYLATION. Golshad Ghojoghi , Deniz Meneksedag-Erol 233-Pos Board B17 INSIGHT INTO THE AUTOPROTEOLYSIS-CONTROLLED SIGNALING OF THE RSGI9 ANTI-Σ FACTOR FROM ACETIVIBRIO THERMOCELLUS . Allen Takayesu , Brendan J. Mahoney, Andrew Goring 234-Pos Board B18 ANION BINDING TO THE ACTIVE SITE OF THERMOLYSIN TRIGGERS HINGE OPENING - IMPLICATIONS FOR SALT ACTIVATION. Douglas H. Juers , Alex Cooper, Alec Salvino, David Wang 235-Pos Board B19 MECHANISMS OF TEMPERATURE COMPENSATION IN CLOCK PRO TEINS. Athira Chilambittaserry Chandradasan 236-Pos Board B20 Travel Award Winner UNDERSTANDING THE STRUCTURAL BASIS OF THE TRANSCRIPTIONAL REGULATION BY HIGA ANTITOXIN. Dipankar Ghorai , Pankaj Jadhav, Nayanika Sengupta, Vikrant K. Sinha, Somnath Dutta, Mahavir Singh 237-Pos Board B21 CAUGHT RED-HANDED: A STRUCTURAL AND MECHANISTIC STUDY OF HOW STAPHYLOCOCCUS AUREUS ISDH STEALS HEME FROM THE HEMOGLOBIN-HAPTOGLOBIN COMPLEX. Jess Soule , Andrew K. Goring, Cameron Flowers, Brendan J. Mahoney, Joseph Loo, Robert T. Clubb, Jose A. Rodriguez 238-Pos Board B22 STRUCTURE DETERMINATION OF THE HERV-K ENVELOPE PROTEIN IN PRE- AND POST-FUSION CONFORMATIONS WITH CRYO-EM. Jeremy Shek , Elise WIlson, Chen Sun, Erica Ollmann Saphire 239-Pos Board B23 Travel Award Winner TRANSCRIPTIONAL REGULATION OF HOST IMMUNE RESPONSES BY HUMAN RESPIRATORY SYNCYTIAL VIRUS NON-STRUCTURAL PROTEIN 1. Parismita Kalita , Oam Khatavkar, Yuying Hu, Yulia Korshunova, Steven L. Brody, Dominika M. Borek, Gaya K. Amarasinghe, Jacqueline E. Pay ton, Daisy W. Leung 240-Pos Board B24 NOROVIRUS MUTANTS MIMIC ACTIVATING CONDITIONS. Faith J. Cox , Michael Sherman, Hong Q. Smith, Thomas J. Smith 241-Pos Board B25 STRUCTURAL DESIGN AND CHARACTERIZATION OF PREFUSION STABILIZED CORONAVIRUS S2 PROTEINS IN COMPLEX WITH ANTIBOD IES. Adonis Rubio , Morgan Abernathy, Yu Lee, Michael Eso, Davide Robbiani, Christopher O. Barnes Board B13

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217-Pos Board B1 MOLECULAR MECHANISM OF BMP SIGNALING INHIBITION BY TWISTED GASTRULATION. Tomas Malinauskas , Gareth Moore, Amalie F. Rudolf, Holly Eggington, Hayley L. Belnoue-Davis, Kamel El Omari, Samuel C. Griffiths, Rachel E. Woolley, Ramona Duman, Armin Wagner, Simon J. Leedham, Clair Baldock, Hilary L. Ashe, Christian Siebold 218-Pos Board B2 Travel Award Winner CHARACTERIZING THE GSK3/NAV1.6 PROTEIN-PROTEIN INTERACTION COMPLEX. Akanksha Gurtu , Aditya K. Singh, Timothy Baumgartner, Jully Singh, Zahra Haghighijoo, Mark A. White, Fernanda Laezza 219-Pos Board B3 THE ROLE OF REVERSIBLE PROTEIN-PROTEIN INTERACTIONS IN THE BIOPHYSICAL PROFILE OF NOVEL MONOCLONAL ANTIBODY THERA PIES. Jack Maurer , Peyton Randolph, Lisa Hughes, Kristina Zick 220-Pos Board B4 Travel Award Winner ATOMISTIC INSIGHTS INTO DOMAIN SWAPPING MECHANISMS IN ANTIBODY LIGHT CHAINS: A MOLECULAR SIMULATION STUDY. Kowit Hengphasatporn , Lian Duan, Yasuteru Shigeta 221-Pos Board B5 AVANA: AN OPEN-SOURCE VMD PLUGIN FOR KABAT ANTIBODY AN NOTATION AND VISUALIZATION. Payam Kelich , Giuseppe Licari, Emad Tajkhorshid 222-Pos Board B6 MEASURING THE STRUCTURAL DYNAMICS OF NIST MONOCLONAL AN TIBODY USING HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROM ETRY (HDX-MS). Sandeep Kumar , Kyle W. Anderson 223-Pos Board B7 Travel Award Winner HUMAN INFECTION WITH ENTEROTOXIGENIC E. COLI ELICITS MULTIPLE MODES OF ANTIBODY-MEDIATED INHIBITION OF THE EATA MUCIN DEGRADING PROTEASE. David P. Buckley , Tim J. Vickers, Ali Ellebedy, Zachary T. Berndsen, James M. Fleckenstein 224-Pos Board B8 DESIGN AND CONFORMATIONAL STUDY OF STA ANALOGUES FOR TOXOID VACCINE DEVELOPMENT AND CANCER DETECTION. Yuji Hidaka , Masaya Goto, Shinya Yoshino, Shigeru Shimamoto 225-Pos Board B9 INVESTIGATING THE STRUCTURAL BASIS OF INTERACTION BETWEEN COMPLEMENT COMPONENT C3DG AND GOLD NANOPARTICLES. Tanveer Shaikh , Abriana Ferrari, Nicholas C. Fitzkee 226-Pos Board B10 STRUCTURE OF YEAST RAVE BOUND TO A PARTIAL V 1 COMPLEX. Hanlin Wang , Maureen Tarsio, Patricia M. Kane, John Rubinstein 227-Pos Board B11 STRUCTURAL BASIS OF THE CATALYTIC AND ALLOSTERIC MECHANISM OF BACTERIAL ACETYLTRANSFERASE PATZ. Junbae Park, Gwanwoo Lee, Yu-Yeon Han , Yeong-Jae Seok, Soung-Hun Roh 228-Pos Board B12 DISPARATE BIOPHYSICAL AND BIOCHEMICAL PROPERTIES OF TWO MYBPC3 MUTANTS ASSOCIATED WITH HYPERTROPHIC CARDIOMYOPA THY. Michail Nomikos , Emna Riguene, Angelos Thanassoulas, Maria Theodoridou, Laila Barrak, Sahar I. Da’as, F. Anthony Lai, Mohamed A. Elrayess

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