BPS2025 Full Program

268-Pos Board B52 UNDERSTANDING INTERACTIONS BETWEEN THE MITOCHONDRIAL PORIN VDAC2 AND THE PRO-APOPTOTIC PROTEIN BAX. Varun Ravishankar , Laidy Maidel Alvero González, Valerie Prima, Maria Queralt-Martin, Guillaume Gerbaud, Lucie Bergdoll 269-Pos Board B53 ANTAGONIST-TO-AGONIST SWITCH DRIVES HIGHER ORDER OLIGOMER IZATION IN THE MINERALOCORTICOID RECEPTOR. Julián Weller-Pérez, Zuleima Ramos-Hernández, Diego Alvarez de la Rosa 270-Pos Board B54 QUANTIFYING AND PREDICTING ANTIBODY NON-SPECIFICITY IN THE CLINICAL LANDSCAPE: MICROFLUIDICS AND MACHINE LEARNING. Ella de Csillery , Hannes Ausserwöger, Marc Oeller, Isabel Waibel, Rahmad Akbar, Alexandru Abrudan, Georg Krainer, Gaetano Invernizzi, Paolo Arosio, Nikolai Lorenzen, Tuomas Knowles Protein Dynamics and Allostery I (Boards B55 - B84) 271-Pos Board B55 IDENTIFYING PROTEIN DYNAMICAL STATES USING CORRELATION MAP DISTANCE. Dror Tobi , Yuval Valenci 272-Pos Board B56 GENERAL PRINCIPLES OF ALLOSTERIC ACTIVITY REGULATION IN GLUTA MINE AMIDOTRANSFERASE MULTIENZYME COMPLEXES FOR SYNCHRO NIZED CATALYSIS. Matthias Wilmanns , Reinhard Sterner 273-Pos Board B57 MECHANICAL FORCE TRIGGERS FAK PHOSPHORYLATION TO REGULATE PROTEIN FOLDING DYNAMICS AND PAXILLIN BINDING. Greta Griniute, Rafael Tapia-Rojo 274-Pos Board B58 PH- AND POST-TRANSLATIONAL MODIFICATION-DEPENDENT STRUC TURAL DYNAMICS AND REGULATION OF BRAIN-TYPE CREATINE KINASE. Samantha Gies, Nolan K. McLaughlin, Juan Pablo Pabon Rincon, Michael L. Gross, Reza Dastvan 275-Pos Board B59 ELUCIDATING WATER-MEDIATED ALLOSTERY IN AN ENZYME. Eugene Klyshko, Sarah Rauscher 276-Pos Board B60 INTEGRATIVE BIOPHYSICS OF ALLOSTERIC INTERACTIONS AND DISRUP TION IN ESTROGEN RECEPTOR. Sichun Yang 277-Pos Board B61 KINETIC MODEL OF LOAD-DEPENDENT TCR-PMHC CONFORMATIONAL TRANSITION AND DISSOCIATION. Wonmuk Hwang , Hannah Stephens, Robert J. Mallis, Ellis L. Reinherz, Matthew J. Lang 278-Pos Board B62 UNRAVELING THE DYNAMICS OF PHOSPHOGLYCERATE KINASE: REAL TIME INSIGHTS FROM SINGLE-MOLECULE FRET. David Scheerer , Dorit Levy, Maria C. Ghetu, Inbal Riven, Remi Casier, Yuval Mor-Scheerer, Alon Wenger, Anastasia Venets, Gilad Haran 279-Pos Board B63 FACTOR XIII RESIDUES CRUCIAL FOR FORMING A SUBSTRATE RECOG NITION SITE. Rameesa D. Syed Mohammed, Lianay Gutierrez Luque, Daniel Deredge, Muriel Maurer 280-Pos Board B64 CALCIUM-MEDIATED STRUCTURAL DYNAMICS AND ZINC SEQUESTRA TION IN S100A12: INSIGHTS FROM NMR AND MOLECULAR DYNAMICS STUDIES. Qian Wang

281-Pos Board B65 MAPPING ALLOSTERIC INTERACTIONS: UNRAVELING FUNCTIONAL NETWORKS IN HUMAN GLUTAMINE SYNTHETASE. Markus C. Tecson , Dan R. Fournier, Cyrina Joy Geluz, Ryan Leung, Madison Hales, Sophia Parmigiani, Hiroki Yamamura, Eric R. Greene 282-Pos Board B66 UNVEILING THE ALLOSTERIC REGULATION OF HUMAN GLUTAMINE SYNTHETASE: INSIGHTS FROM CRYO-EM, MOLECULAR DYNAMICS, AND STRUCTURAL ANALYSIS. Cyrina Joy Geluz , Markus Tecson, Dan R. Fournier, Ryan Leung, Madison Hales, Sophia Parmigiani, Hiroki Yama mura, Eric R. Greene 283-Pos Board B67 DIFFERENTIAL POSITIONING OF ALLOSTERIC BINDING SITES BETWEEN CYCLOOXYGENASE-1 AND -2. Inseok Song 284-Pos Board B68 ORIENTATION-DEPENDENT ELECTROSTATIC INTERACTIONS BETWEEN BROADLY NEUTRALIZING HIV-1 MPER ANTIBODIES AND VIRUS-MIMETIC MEMBRANE. Yue Qiu , Kemin Tan, Thomas Walz, Mikyung Kim, Ellis L. Reinherz, Wonmuk Hwang 285-Pos Board B69 COMPUTATIONAL APPROACHES TO UNCOVER CHANGES IN THE AL LOSTERY OF MICROTUBULE SEVERING ENZYMES. Shehani Kahawatte , Madhavie Ranpati Dewage, Maria S. Kelly, Amanda C. Macke, Ruxandra I. Dima 286-Pos Board B70 INVESTIGATING THE ALLOSTERIC PROBE-DEPENDENCE OF BMS-986121 IN Μ-OPIOID RECEPTOR-G PROTEIN COMPLEX THROUGH CONTACT CORRELATION ANALYSIS. Jherome Brylle Woody A. Santos , James Peter L. Lim, Mac Kevin E. Braza, Ricky B. Nellas 287-Pos Board B71 LANGEVIN MODELING OF PROTEIN DYNAMICS AND THE WEIGHTED ENSEMBLE SIMULATIONS. Hiroshi Fujisaki , Kei Moritsugu 288-Pos Board B72 CALMODULIN KINETICS AND CA2+ DEPENDENCE REVEALED BY INTRA MOLECULAR FRET. Pavel Kirilenko, Dafydd Jones, Ewan D. Fowler 289-Pos Board B73 BIOPHYSICAL INSIGHTS INTO ALLOSTERIC MODULATION AND INHI BITION OF VIRAL PROTEASES USING MD SIMULATIONS. Marion Q. LoPresti , Kelsie M. King, Anne M. Brown 290-Pos Board B74 USING MACHINE LEARNING TECHNIQUES TO CHARACTERIZE THE FUNC TIONAL STATES OF HSP104. Tharushi Rajaguru , Sumedhi Jayasekara, Ashan Dayananda, George Stan 291-Pos Board B75 STRUCTURAL DYNAMICS OF SPHINGOSINE KINASE 1 REGULATION AND INHIBITION. Baharak Abd Emami , Reza Dastvan 292-Pos Board B76 INVESTIGATING AN HA MEDIATED MECHANISM OF AVIAN IAV HOST TROPISM WITH SMFRET. Matthew Unger , James B. Munro 293-Pos Board B77 SINGLE-MOLECULE FRET TO STUDY MOLECULAR MECHANISMS OF BIOMOLECULAR CONDENSATION. Daniel Scholl , Emily Bentley, Peter E. Wright, Keren Lasker, Ashok Deniz 294-Pos Board B78 UNCOVERING MECHANISMS OF DISTANT COMPENSATION IN PROTEIN COMPLEXES USING LARGE-SCALE MOLECULAR DYNAMICS SIMULA TIONS. Shubham Mittal , Yazdan Maghsoud, Gerardo A. Cisneros, Faruck Morcos

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