BPS2025 Full Program

426-Pos Board B210 A SINGLE-MOLECULE MAGNETIC TWEEZERS INVESTIGATION OF THE MECHANISM OF INNATE IMMUNE SIGNALING ACTIVATION BY MDA5. Salina Quack, Sourav Maity, Pim America, Misha Klein, Alba H. del Valle, Rahul Singh, Quinte Smitskamp, Chase P. Broedersz, Wouter H. Roos, Yorgo Modis, David Dulin 427-Pos Board B211 Travel Award Winner INVESTIGATING THE DNA TARGET RECOGNITION BY CRISPR-CAS9 WITH ULTRAFAST SINGLE-MOLECULE TWIST MEASUREMENTS. Fabian Welzel , Julene Madariaga Marcos, Dominik J. Kauert, Ralf Seidel 428-Pos Board B212 A CRYPTIC-METAL BINDING POCKET REGULATES THE CONFORMA TIONAL ACTIVATION IN CRISPR-CAS9. Mohammad Ahsan , Aakash Saha, Isabel Strohkendl, Erin Skeens, George Lisi, David W. Taylor 429-Pos Board B213 PROTEIN-DNA COMPLEX DETECTION BY PROTEIN CHARGE TRANSFER SPECTRA. Nuzelu V. 430-Pos Board B214 THE STRUCTURAL BASIS OF NUCLEAR RECEPTOR ACTIVATION ON CHRO MATIN. Timothy Strutzenberg , Jordan Kelsey, Hyejeong Shin, Matthew Mann, Patrick Griffin, Dmitry Lyumkis 431-Pos Board B215 ELECTROSTATICS, LOCAL CONFORMATIONS, AND MOLECULAR RECOG NITION IN VERSATILE RNA-BINDING PROTEINS. Sasha Moonitz, Nhat Do, Rodrigo Noriega 432-Pos Board B216 RAPID TWO-STEP TARGET CAPTURE ENSURES EFFICIENT CRISPR-CAS9 GUIDED GENOME EDITING. Honglue Shi , Noor Al-Sayyad, Kevin Wasko, Marena I. Trinidad, Erin E. Doherty, Kamakshi Vohra, Ron Boger, David Colognori, Joshua Cofsky, Petr Skopintsev, Zev Bryant, Jennifer A. Board B217 STRUCTURAL INTEGRITY AND SIDE-CHAIN INTERACTION AT LOOP REGION PF THE BRIDGE-HELIX MODULATE CAS9 SUBSTRATE DISCRIMI NATION. Difei Wu, Sydney Newsom, Chhandosee Ganguly, Rakhi Rajan, Peter Z. Qin 434-Pos Board B218 COMPARATIVE STRUCTURAL DYNAMICS AND ENERGETICS OF DIMERIC TRANSCRIPTION FACTORS MYC-MAX, OMOMYC, AND MAX-MAX ON EBOX AND POLYA DNA. Carmen Al Masri , Jin Yu Membrane Physical Chemistry I (Boards B219 - B239) 435-Pos Board B219 ENGINEERING ASYMMETRIC NANOSCALE LIPID VESICLES FOR DRUG DELIVERY. Kevin Jahnke , Chenjing Yang, David A. Weitz 436-Pos Board B220 APPLICATION OF SULFO-DIISOBUTYLENE/MALEIC ACID BASED NANO DISCS FOR THE CHARACTERIZATION OF ANIONIC PHOSPHOLIPID/BIVA LENT CATION INTERACTIONS. Arne Gericke , Peter Oni 437-Pos Board B221 POLYMER-ASSISTED ASSEMBLY OF CELL-MIMETIC GIANT VESICLES IN PHYSIOLOGICAL IONIC SOLUTIONS. Alexis Cooper , Anand B. Subrama niam Doudna 433-Pos

438-Pos Board B222 MULTIPLEXING AND THE ROLE OF BUOYANCY FORCES IN FORMING SOLID SUPPORTED LIPID BILAYERS IN THIN FLOW CELLS. Megan E. Mitchell , Frank Heinrich, David P. Hoogerheide 439-Pos Board B223 NANOTEMPLATE APPROACH TO STABILIZE MACROSCOPICALLY ALIGNED LIPID BILAYERS AND MEMBRANES PROTEINS IN DRY STATE. Peter Cao, Sergey Milikisiyants, Alex I. Smirnov 440-Pos Board B224 SHAPE OF A TRAVELLING PROTON WAVE NORMAL TO THE LIPID BI LAYER. Anna Maznichenko, Denis G. Knyazev, Peter Pohl 441-Pos Board B225 LOCAL ELECTROSTATICS OF TRANSMEMBRANE DOMAINS BY SPIN LA BELING EPR. Tatyana I. Smirnova , Maxim A. Voinov, Sergey Milikisiyants, Gabriel A. Cook, Alex I. Smirnov 442-Pos Board B226 MEMBRANE BINDING OF HYDROPHOBIC IONS: DIPOLE POTENTIAL REVISITED. Alexander Baumgart, Ronald J. Clarke , Charles G. Cranfield, Rocco Zerlotti, Francesco Tadini Buoninsegni 443-Pos Board B227 CHOLESTEROL VERSUS PLANT STEROL: THE SOLUBILITY MEASUREMENT IN DPPC LIPOSOMES. Muhammad B. Siddique , Juyang Huang 444-Pos Board B228 COMPARATIVE STEROL DYNAMICS IN MEMBRANES. Shashank Shastry 445-Pos Board B229 INFLUENCE OF STEROL CHEMICAL STRUCTURE ON MEMBRANE OR DER. Laura J.S. Lopes , Israel Juarez-Contreras, Itay Budin, Alexander J. Sodt 446-Pos Board B230 THE INFLUENCE OF MIXED CHAIN LIPIDS ON MEMBRANE PHASE BEHAVIOR AND NANODOMAIN FORMATION. Deeksha Mehta, Emily H. Chaisson , Neal Waxham, Averi M. Cooper, Maryam Ahmed, Frederick A. Board B231 THE IMPACT OF POLYUNSATURATED HYBRID PHOSPHOLIPIDS ON THE PHASE BEHAVIOR OF MODEL LIPID MEMBRANES. Elizabeth K. Crumley , Frederick A. Heberle 448-Pos Board B232 PARAMETRIZATION OF CHARMM36 SPHINGOMYELIN INTERMOLECU LAR HYDROGEN BONDING. Anthony J. Pane , Zack Jarin, Richard W. Pastor, Jeffery B. Klauda 449-Pos Board B233 INVESTIGATING CURVATURE-DEPENDENT NANODOMAIN STRUCTURE IN LIPID BILAYER VESICLES USING CRYOGENIC ELECTRON MICROSCO PY. Deeksha Mehta , Frederick A. Heberle, Neal Waxham 450-Pos Board B234 MULTI-COMPONENT MEMBRANE MODELS TO INVESTIGATE THE INFLUENCE OF VISCOELASTIC PROPERTIES ON EXTRACELLULAR VESICLE UPTAKE PATHWAYS. Loredana Casalis 451-Pos Board B235 DIFFERENTIAL TENSION INCURRED BY LIPID NUMBER ASYMMETRY MODULATES THE CHEMICAL ACTIVITY OF LIPIDS, BIASING THEIR BIOCHEMICAL AVAILABILITY. Tyler R. Reagle , Kandice R. Levental, Ilya Levental Heberle 447-Pos

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