BPS2025 Full Program

528-Pos Board B312 RYANODINE RECEPTOR-1 CONTRIBUTES TO ALTERATIONS IN ORGAN ELLAR CALCIUM SIGNALING AND MODULATES GENE EXPRESSION IN HIGH-GRADE SEROUS OVARIAN CANCER (HGSOC). Kay-Pong D. Yip, Wan-Yee Tang, Chi-Lam Au-Yeung, Samuel C. Mok, James S. Sham 529-Pos Board B313 DISEASE-ASSOCIATED RYANODINE RECEPTOR 2 MUTATIONS PROMOTE DYSREGULATION OF SUBCELLULAR REDOX NANODOMAINS. David M. Booth, Hui-Ying Tsai, Xiaoxin Li, Shey-Shing Sheu 530-Pos Board B314 ARRHYTHMOGENIC CALCIUM SIGNALING IN TRANSPLANTED HU MAN PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES. Andrew P. Wescott , Silvia Marchiano, Nora Perrault, Leslie P. Blakely, W. Robb MacLellan, Charles E. Murry 531-Pos Board B315 ABLATION OF THE MITOCHONDRIAL CALCIUM UNIPORTER IMPROVED CALCIUM HOMEOSTASIS IN A MOUSE MODEL OF DIABETIC CARDIOMY OPATHY BY INHIBITING ROS PRODUCTION. Arpita Deb, Valeria Gomez, Ngoc Nguyen, Oluwabori Adekanye, Bin Liu 532-Pos Board B316 REGULATION OF THE MITOCHONDRIAL CALCIUM UNIPORTER BY THE CHOLESTEROL-LOWERING DRUG EZETIMIBE. Alexander B. Rister , Thomas Gudermann, Johann Schredelseker 533-Pos Board B317 CALCIUM CHANNEL AND TRANSPORTER TARGETED MODULATORS IDENTIFIED BY FRET-BASED HIGH-THROUGHPUT SCREENING. Jonathan C. Solberg, Samantha L. Yuen, Michael E. Fealey, Marzena Brinkmann, Benjamin D. Van Setters, Andrew R. Thompson, Courtney C. Aldrich, Donald M. Bers, David D. Thomas, Robyn T. Rebbeck 534-Pos Board B318 DISRUPTED SERCA REGULATION BY ENDOREGULIN LEADS TO DYSFUNC TION IN VASCULAR ENDOTHELIAL CELLS. Rhys A. Smith 535-Pos Board B319 DYSTROPHIN DEFICIENCY INCREASES THE PREVALENCE OF ECTOPIC ATRIAL ELECTRICAL ACTIVITY. Jessica Cayton , Ava Fleury, Tim Domeier Muscle Regulation (Boards B320 - B331) 536-Pos Board B320 NEPRILYSIN CLEAVES PHOSPHOLAMBAN C-TERMINUS, DISRUPTING SERCA REGULATION IN HEART FAILURE. Jacob D. Cunningham , Taylor Phillips, Ellen E. Cho, Seth L. Robia 537-Pos Board B321 EFFECTS OF PHOSPHORYLATED CMYBP-C ON SPONTANEOUS OSCILLA TORY CONTRACTIONS. Dylan Reichert , Samantha P. Harris 538-Pos Board B322 IN SILICO ANALYSIS OF CONFORMATIONAL DYNAMICS OF THE ALPHA ACTININ-2 ACTIN BINDING DOMAIN UPON PHOSPHORYLATION. Christopher Solís , Matthew C. Childers, Michael Regnier 539-Pos Board B323 ADENO-ASSOCIATED VIRUS ENFORCED ALDH3A1 EXPRESSION PRO TECTS MYOTUBES AGAINST 4-HNE INDUCED CYTOTOXICITY AND RE STORES MG53 MEDIATED MEMBRANE REPAIR. Ang Li, Li Dong , Xuejun Li, jianxun yi, Jianjie Ma, Jingsong Zhou 540-Pos Board B324 SUR2, BUT NOT KIR6.1, K ATP CHANNEL GAIN-OF-FUNCTION DIRECTLY AFFECTS SKELETAL MUSCLE CONTRACTILITY IN MURINE MODELS OF CANTU SYNDROME. Rosa Scala , Maya Mukadam, Nathaniel W. York, Gretchen Meyer, Colin G. Nichols

541-Pos Board B325 LIPID WASTING AND PEROXIDATION CONTRIBUTE TO IMPAIRED MEM BRANE REPAIR FUNCTION IN SKELETAL MUSCLE OF ALS MICE. Jianxun Yi, Li Dong, Xuejun Li, Ang Li, Kyung Eun Lee, Jianjie Ma, Jingsong Zhou 542-Pos Board B326 HEMODYNAMIC AND MYOCARDIAL STRAIN ANALYSES REVEAL GLOBAL AND REGIONAL DIASTOLIC DYSFUNCTION IN A TNNC1-A8V MOUSE MODEL ASSOCIATED WITH HUMAN PEDIATRIC HCM/RCM. Paula F. Nieto Morales , Sadie Gregory, Amanda M. Mascarenhas, Minu Tshyeto Bidzimou, Bo Sun, Michael O. Assibey, Karissa Dieseldorff Jones, Vitold E. Galkin, Prescott B. Chase, Rosemeire Kanashiro-Takeuchi, Stephen Chelko, Andrew P. Landstrom, J. Renato D. Pinto 543-Pos Board B327 EFFECT OF THE E525K MYOSIN MUTATION ON MYOFILAMENT CON TRACTION—UNDERSTANDING HYPOCONTRACTION IN THE CONTEXT OF INCREASED ATPASE ACTIVITY. Kalen Z. Robeson , Kieran Fruebis, Rachelle Soriano, Jennifer M. Davis, Michael Regnier 544-Pos Board B328 MYOSIN REGULATORY LIGHT CHAIN KINASE AND PROTEIN KINASE A, ALONE AND IN COMBINATION, COORDINATE CONTRACTILE FUNCTION VIA MYOFILAMENT PHOSPHORYLATION. Kyrah Turner , Bertrand C.W. Tanner 545-Pos Board B329 PHENOTYPE CHARACTERIZATION OF TNNT1 EXON 8 SPLICE-OUT MUTA TION IN MICE REVEALS NOVEL PATHOGENIC AND PATHOPHYSIOLOGIC MECHANISMS. Han-Zhong Feng , J.-P. Jin 546-Pos Board B330 DIFFERENTIAL EFFECTS OF EXTRACELLULAR MATRIX-RELATED ALTERA TIONS ON MYOSIN HEAVY AND LIGHT CHAIN EXPRESSION IN HUMAN STEM CELL-DERIVED CARDIOMYOCYTES. Felix Osten , Natalie Weber, Tim Holler, Birgit Piep, Simon Kröhn, Alea K. Bodenschatz, Jana Teske, Robert Zweigerdt, Theresia Kraft, Bogdan Iorga, Joachim D. Meissner 547-Pos Board B331 NOVEL INSIGHTS INTO BAG3 PROTEOLYSIS IN HEART FAILURE AND LYSOSOMAL KINETIC IMPAIRMENT IN CARDIOMYOCYTES VIA HIGH-RES OLUTION IMAGING. Ahmed Zied , Laura A. Sherer, Jonathan A. Kirk Voltage-Gated Na Channels (Boards B332 - B365) 548-Pos Board B332 Travel Award Winner SELECTIVE ENHANCEMENT OF NA V 1.5 OPENING OVER FAST INACTIVA TION BY LOSS OF A SINGLE METHYL GROUP IN A CPVT-ASSOCIATED VARIANT. Serena Pozzi , Orgena Dano, Alessia Golluscio, Pia Dahlberg, Linda Bulmer, Michelle Nilsson, Anders Nygren, Anders Gummesson, Jonathan R. Silva, Peter H. Larsson, Antonios Pantazis 549-Pos Board B333 HNAV1.1 COUNTERCHARGE MUTATIONS IN EPILEPSY SYN DROMES. James R. Groome 550-Pos Board B334 MEASUREMENT OF GATING PORE CURRENT IN NAV1.5 WITH R219H USING A NEWLY IDENTIFIED DISEASE-ASSOCIATED PORE BLOCK MUTA TION. Natsuki Kira , Aya Miyanooto, Reina Yamamoto, Satoe Takahashi, Kazuaki Homma, Yoshihiro Asano, Mariko Eguchi, Masanori P. Takahashi, Tomoya Kubota 551-Pos Board B335 DE NOVO PROTEIN DESIGN OF MODULATORS TARGETING HUMAN NA V 1.5 CHANNEL. Brandon J. Harris , Vladimir Yarov-Yarovoy

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