BPS2025 Full Program

552-Pos Board B336 DEVELOPMENT OF A HIGH THROUGHPUT AUTOMATED ELECTROPHYSI OLOGY ASSAY FOR HUMAN NA V 1.9 INHIBITOR SCREENING. Graham D. Smith, Katie L. Puddefoot, Sergiy Tokar, Alexander Haworth, Catherine M. Hodgson, Thomas D.M. Hill, Ayesha. Jinat, Anthony M. Rush, Edward B. Stevens , Gary S. Clark 553-Pos Board B337 LIGHT-INDUCED ACTION POTENTIALS AND STEM CELL-DERIVED SEN SORY NEURONS: AN AUTOMATED PATCH CLAMP INVESTIGATION. Kefan Yang, Irene Lu, Timothy Strassmaier, Tom Götze, Patrick Mumm, Alison Obergrussberger , Nadine Becker, Michael George, Niels Fertig 554-Pos Board B338 COMPUTATIONAL MODELING OF C-TERMINAL LOOP OF VOLTAGE-GAT ED SODIUM CHANNEL 1.4 IN HUMANS AND GRASSHOPPER MICE. Evan R. Jones , Ashlee Rowe, Yihan Shao 555-Pos Board B339 Travel Award Winner DETERMINING THE IMPACT OF PHOSPHORYLATION ON NAV1.5 IN TRACELLULAR PROTEIN-PROTEIN INTERACTIONS BY TANDEM PROTEIN TRANS-SPLICING. Laurie Peverini , Stephan A. Pless 556-Pos Board B340 DE NOVO DESIGN OF A PEPTIDE MODULATOR THAT INHIBITS ARRHYTH MOGENIC LATE NA CURRENT. Ryan W. Mahling , Bence Hegyi, Timothy M. Cho, Lucile Fossier, Alexander N. Katchman, Lyn Yang, Steven O. Marx, Donald M. Bers, Manu Ben-Johny 557-Pos Board B341 CALMODULIN MODULATION OF PERSISTENT SODIUM CURRENT ACROSS NAV ISOFORMS. Timothy M. Cho , Ryan W. Mahling, Manu Ben-Johny 558-Pos Board B342 INTERACTION SITE AND MECHANISM OF ACTION OF DIVERSE SELECTIVE NAV1.8 INHIBITORS. Nien-Du Yang , Chun Chien, Shanti M. Amagasu, Victoria Jiang, Bryan D. Moyer, John M. Gilchrist 559-Pos Board B343 BLOCK OF VOLTAGE- AND LIGAND-GATED ION CHANNELS BY TOXINS USING AUTOMATED PATCH CLAMP - A DETECTION TOOL? Alison Obergrussberger , Nadine Becker, Francesc X. Sureda, Monica Campas, Michael George, Niels Fertig 560-Pos Board B344 MOLECULAR DYNAMICS SIMULATION OF THE SODIUM CHANNEL NAV1.4 IN A CLOSED-STATE CONFORMATION. Gourav Saha , J. Alfredo Freites, Steve C. Cannon, Douglas J. Tobias 561-Pos Board B345 ASSESSING THE ROLE OF SODIUM CHANNEL FAST-INACTIVATION IN THE MECHANISM OF ARYL/ACYL- SULFONAMIDE INHIBITION. Samantha G. Thompson , Colin Clark, Lionel Gissot, Jason D. Galpin, Daniel T. Infield, Christopher A. Ahern 562-Pos Board B346 STRUCTURAL BASIS OF HUMAN NA V 1.5 GATING MECHANISMS. Rupam Biswas , Ana Laura Lopez Serrano, Apoorva Purohit, Angelina Ramirez Navarro, Hsiang Ling Huang, Giovanna Grandinetti, Xiaolin Cheng, Sarah M. Heissler, Isabelle Deschenes, Krishna Chinthalapudi 563-Pos Board B347 DEVELOPMENT OF AN AUTOMATED PATCH CLAMP ASSAY TO EVALUATE USE-DEPENDENT RELIEF OF INHIBITION OF NAV1.8 INHIBITORS. Shanti M. Amagasu , John M. Gilchrist, Bryan D. Moyer 564-Pos Board B348 MOLECULAR DYNAMICS SIMULATIONS OF FULL-LENGTH PROTEINS TO PROBE THE IMPACT OF POST-TRANSLATIONAL MODIFICATIONS ON PROTEIN DYNAMICS. Maral Afshinpour , Suvobrata Chakravarty

565-Pos Board B349 DO PERMEANT IONS CROSS A VOLTAGE SENSITIVE ION CHANNEL THROUGH A DETERMINISTIC PORE OR PROBABILISTIC DEFECT LINES? H. Richard Leuchtag 566-Pos Board B350 EVALUATING AN IMPACT OF NAVΒ1 SUBUNIT FOR THE NAV1.4 CHAN NEL MEMBRANE EXPRESSION EFFICACY THROUGH AN OPTICAL MEA SUREMENT. Reina Yamamoto , Kosuke Yamauchi, Satoe Takahashi, Yuna Mizobata, Kazuaki Homma, Tomoya Kubota, Masanori P. Takahashi 567-Pos Board B351 CAM SPECIFIC MECHANISMS OF FGF12A INTERACTION WITH NAV1.5. Lucy S. Woodbury , Paweorn Angsutararux, Martina Marras, Anna Li, Jonathan R. Silva 568-Pos Board B352 IMPROVED DESCRIPTIONS OF VOLTAGE-GATED SODIUM CHANNEL C TERMINAL DOMAIN INTERACTIONS. Spencer Lile 569-Pos Board B353 ELUCIDATING THE EFFECTS OF DISEASE-ASSOCIATED MUTATIONS FOR FAST INACTIVATION IN VOLTAGE-GATED SODIUM CHANNELS. Shiva Akhlaghi , Jing Li 570-Pos Board B354 ELUCIDATING MOLECULAR MECHANISMS OF GATING REGULATION BY N-GLYCOSYLATION IN VOLTAGE-GATED SODIUM CHANNELS. Eslam Elhanafy , Jing Li 571-Pos Board B355 UNEXPECTED CA 2+ -DEPENDENT NA V 1.5 DYSREGULATION BY ARRHYTH MOGENIC CAM MUTATIONS. Zoja Selimi , Rengasayee Veeraraghavan, Przemyslaw Radwanski 572-Pos Board B356 DECODING DYNAMICS TO UNDERSTAND NATURE: WHAT SETS GARTER SNAKE SODIUM CHANNELS APART IN THEIR FIGHT AGAINST TETRODO TOXIN? Kait Malewicz , Julia M. Montgomery, Joel W. McGlothlin, Justin A. Lemkul 573-Pos Board B357 THE EFFECT OF NATURAL LITHIUM AND LITHIUM ISOTOPES ON VOLT AGE‐GATED SODIUM CHANNEL ACTIVITY IN SH-SY5Y AND IPSC-DERIVED CORTICAL NEURONS. Irina Bukhteeva , Kartar Singh, James Livingstone, Evgeny Pavlov, Michael Beazely, Michel Gingras, Zoya Leonenko 574-Pos Board B358 CARDIAC VOLTAGE-GATED SODIUM CHANNELS ARE A COMMON PATH OLOGICAL PATHWAY IN COVID-19 INDUCED ARRHYTHMIA. Mohamed A. Fouda , Yasmine Fathy Mohamed, Rachel Fernandez, Peter C. Ruben 575-Pos Board B359 EXPLORING VOLTAGE-GATED SODIUM CHANNEL CONFORMATIONS AND INTERACTIONS USING ALPHAFOLD. Diego Lopez Mateos , Kush Narang, Vladimir Yarov-Yarovoy 576-Pos Board B360 A HIS BUTTON ON NA V 1.5 MODIFIES ION CHANNEL ACCESSORY PROTEIN INTERACTION AND GATING IN RESPONSE TO CHANGES IN INTRACELLULAR PH. Taylor A. Agee , Garrett M. Knotts, Justin R. Lovett, Spencer K. Lile, Emily M. Campbell, Yusuf Olgar, Christopher N. Johnson 577-Pos Board B361 FROM MUTATION TO DYSFUNCTION: EXPLORING THE EFFECT OF NA V 1.5 SELECTIVITY FILTER IN ARRHYTHMIA PATHOGENESIS. Zoja Selimi , Mikhail Tarasov, Xiaolei Meng, Patricia Dias, Bianca Ioana Moise, Renga sayee Veeraraghavan, Przemyslaw Radwanski

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