BPS2025 Full Program

578-Pos Board B362 CHARACTERIZING CCO-TX3 TOXIN BINDING SITE IN NAV1.5 CHAN NEL. Erbio Diaz, Janin Riedelsberger, Wendy Gonzalez 579-Pos Board B363 PREDICTING AND INVESTIGATING GATING PORE CURRENTS IN VOLTAGE SENSOR MUTATIONS OF DOMAIN I IN NA V 1.2 BRAIN SODIUM CHAN NEL. Ahmed Eltokhi, Eslam Elhanafy, Jing Li, Tamer M. Gamal El-Din 580-Pos Board B364 UNRAVELLING THE MECHANISMS OF ION SELECTIVITY IN SODIUM AND SODIUM LEAK CHANNELS. Angelika Janaszkiewicz , Emelie Flood, Celine Boiteux, Han Chow Chua, Stephan A. Pless, Toby W. Allen 581-Pos Board B365 SEQUENTIAL CONFORMATIONAL CHANGES DURING FAST INACTIVATION IN VOLTAGE GATED SODIUM CHANNELS. Yichen Liu , Jason D. Galpin, Christopher A. Ahern, Francisco Bezanilla Voltage-Gated K Channels I (Boards B366 - B385) 582-Pos Board B366 PHOSPHORYLATION OF KV7.2 HELIX B DIFFERENTIALLY AFFECTS CALMODULIN AND PIP2 BINDING, AXONAL SURFACE EXPRESSION AND FUNCTION. Hongyu Zhao, Jiaren Zhang, Cade Duckworth, Emad Tajkhor shid, Hee Jung Chung 583-Pos Board B367 PIP2 INFLUENCES KV7.2 REGULATION BY VOLTAGE-SENSOR TARGETED DRUGS. Thomas M Hammond , Shawn M. Lamothe, Harley T. Kurata 584-Pos Board B368 ENHANCED K V 7.2 CHANNEL ACTIVITY CAN LEAD TO HYPEREXCITABIL ITY. Moses Kamwela , Carlos A. Villalba-Galea 585-Pos Board B369 BIOPHYSICAL AND PHARMACOLOGICAL CHARACTERIZATION OF KV7.4 CHANNELS USING AUTOMATED PATCH CLAMP. Kim Boddum, Pietro Scaduto , Anissa Bara, Naja Møller M. Sørensen 586-Pos Board B370 CHOLESTEROL HAS A UNIQUE BINDING FINGERPRINT IN K V 7.5. Ricardo Pan , Ali S. Kusay, Damon J.A. Frampton, Lucie Delemotte, Sara I. Liin 587-Pos Board B371 VOLTAGE SENSING MECHANISM OF KV7.5 CHANNELS. Iqra Shams 588-Pos Board B372 IMPACT OF CALMODULIN AND PHOSPHORYLATION ON KV7 VOLTAGE GATED POTASSIUM CHANNELS. Cade Duckworth , Jiaren Zhang, Hee Jung Chung, Emad Tajkhorshid 589-Pos Board B373 THE EFFECTS OF EXTERNAL BARIUM ON HUMAN KCNQ1 POTASSIUM CHANNELS. Lei Huang , Jingyi Shi, Borui Zhang, Lu Han, Bernard Attali, Jianmin Cui 590-Pos Board B374 UNRAVELLING THE CHEMICAL DETERMINANTS OF CBD ACTIVITY ON THE KV7 ION CHANNELS. Ali S. Kusay , Michael Pökl, Xiongyu Wu, Lucie Delemotte, Sara I. Liin 591-Pos Board B375 PUFA STABILIZES A CONDUCTIVE STATE OF THE SELECTIVITY FILTER IN IKS CHANNELS. Alessia Golluscio , Jodene R. Eldstrom, Jessica J. Jowais, Marta E. Perez-Rodriguez, Kevin P. Cunningham, Alicia de la Cruz, Xiaoan Wu, Valentina Corradi, D. Peter Tieleman, David Fedida, Peter H. Larsson

592-Pos Board B376 DUAL EFFECTS OF MEFENAMIC ACID ON THE I KS MOLECULAR COM PLEX. Magnus Chan , Marc Pourrier, Jodene R. Eldstrom, Sahakyan Harutyun, Vitya A. Vardanyan, David Fedida 593-Pos Board B377 Travel Award Winner DETERMINE THE ANTI-ARRHYTHMIC POTENTIAL OF NOVEL DRUGS IN LQTS ANIMALS EX VIVO ON ISOLATED WHOLE HEARTS AND IN VIVO . Lucas Dauga , Alicia de la Cruz, Peter H. Larsson 594-Pos Board B378 SYNCHRONIZED TRANSCRIPTION BETWEEN BK CHANNELS AND CAL CIUM SOURCES PRECEDES THEIR FUNCTIONAL COUPLING. Roya Pournejati , Jessica M. Huang, Micheal Ma, Claudia M. Moreno, Oscar Vivas 595-Pos Board B379 GATING AND IONIC CURRENTS REVEAL HOW THE LRRC26 (Γ1) SUBUNIT MODULATES THE BK CHANNEL GATING. Felipe A. Echeverría , Miguel Fernández, Antonio Peña, Osvaldo Alvarez, Ramon Latorre 596-Pos Board B380 ROLE OF BK CHANNEL ALPHA SUBUNIT TYR450 IN CHOLESTEROL REGULATION OF BK-MEDIATED CURRENTS IN CEREBROVASCULAR MYOCYTES. Elizabeth H. Schneider , Sydney M. Hawks, Alex M. Dopico, Anna N. Bukiya 597-Pos Board B381 STRUCTURAL MODEL OF HUMAN BK-BETA2 COMPLEX IN PEPTI DISC. Shubhra Srivastava , Elizabeth Viverette, Pablo Miranda, Zanlin Yu, Mario J. Borgnia, Miguel Holmgren, Raul E. Cachau 598-Pos Board B382 Travel Award Winner CHOLESTEROL REGULATES THE CLUSTERING OF BK CHANNELS. Jessica M. Huang , Michael Ma, Roya Pournejati, Claudia M. Moreno, Oscar Vivas 599-Pos Board B383 CALCIUM BINDING TO THE MTHK PORE AFFECTS SELECTIVITY FILTER OCCUPANCY. Reinier de Vries , Carl Öster, Adam Lange, Wojciech Kopec, Bert L. de Groot 600-Pos Board B384 ENDOGENOUS AND SYNTHETIC ENDOCANNABINOIDS FACILITATE THE ACTIVATION OF WILD TYPE AND DISEASE-MUTATED CARDIAC KV7.1/ KCNE1 CHANNELS. Irene Hiniesto Iñigo, Siri Lundholm, Xiongyu Wu, Akshay Sridhar, Sara I. Liin 601-Pos Board B385 DOCKING ANALYSIS OF CHOLESTEROL TO CRAC MOTIFS IN BK CHAN NELS. Christy Dyer Ion Channel Regulatory Mechanisms I (Boards B386 - B410) 602-Pos Board B386 COOPERATIVE DYNAMICS OF RYR1 DOMAINS WITH CA 2+ ACTIVATION: INSIGHTS FROM MD SIMULATIONS. Pornthep Sompornpisut 603-Pos Board B387 MODULATION OF PIEZO1 CHANNELS KINETICS BY A NATURALLY OCCUR RING FATTY ACID CONTRIBUTES TO ENDOTHELIAL FUNCTIONS. Yurou Cai 604-Pos Board B388 Travel Award Winner PIEZO AND TRANSCIPTION FACTOR AUXILIARY PROTEINS (PTAPS) REGU LATE PIEZO CHANNELS IN SENSORY AND NON-SENSORY CELL TYPES. Zijing Zhou , Xiaonuo Ma, Delfine Cheng, Jinyuan Li, Yixiao Zhang, Charles D. Cox

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