BPS2025 Full Program

605-Pos Board B389 MECHANOSENSTIVE PIEZO1 CHANNEL GATING AND ITS RESPONSE TO DISCRETE STIMULI CONSIDERING WILD TYPE, LOSS OF FUNCTION AND GAIN OF FUNCTION MUTATIONS. Laura Freneda de Oliveira , Stefan Feier, Ruhma Syeda, Ghanim Ullah 606-Pos Board B390 DISRUPTION OF A R395:E398 SALT BRIDGE BY PIP2 SHIFTS THE STATE DISTRIBUTION TOWARDS AN OPEN AND CONDUCTIVE STATE IN HU MAN SMALL-CONDUCTANCE CA 2+- ACTIVATED K + CHANNELS. Ryan L. Woltz , Yang Zheng, Woori Choi, Khoa Ngo, Pauline Trinh, Lu Ren, Phung Thai, Brandon J. Harris, Yanxiao Han, Diego Lopez Mateos, Ebenezer N. Yamoah, Vladimir Yarov-Yarovoy, Igor V. Vorobyov, Xiao-Dong Zhang, Nipavan Chiamvimonvat 607-Pos Board B391 Travel Award Winner PIP2 REGULATES TRAFFICKING OF SMALL-CONDUCTANCE CALCIUM AC TIVATED POTASSIUM SK2 CHANNEL. Pauline Trinh , Ryan L. Woltz, Yang Zheng, Eamonn J. Dickson, Vladimir Yarov-Yarovoy, Igor V. Vorobyov, Ebenezer N. Yamoah, Xiao-Dong Zhang, Rose E. Dixon, Nipavan Chiam vimonvat 608-Pos Board B392 ASSESSING CA2+ DEPENDENCE OF COMPOUNDS ON BK CHAN NELS. Anna Mondini , Riccardo Rizzetto, Simone Brusco, Robert H. Ring, Valentin K. Gribkoff, Jean-Francois Rolland 609-Pos Board B393 CORPORATION OF SELECTIVITY FILTER AND ACTIVATION GATE IN THE C-TYPE INACTIVATION OBSERVED IN PROKARYOTIC SODIUM CHAN NELS. Katsumasa Irie 610-Pos Board B394 COMPUTATIONAL MODELLING OF CALCIUM-DEPENDENT TRANSCRIP TIONAL REGULATION OF L-TYPE CA 2+ CHANNELS AS DRIVER OF ATRIAL FIBRILLATION PROGRESSION. Xin Wen , Lian Laudy, Stefan Meier, Jordi Board B395 BARIUM BINDING TO THE SELECTIVITY FILTER OF KCA3.1 CHANNELS BLOCKS PERMEATION AND TRIGGERS C-TYPE INACTIVATION. Ariel Ben Bassat, Shira Burg, Moshe Giladi, Yoni Haitin, Bernard Attali 612-Pos Board B396 SUPRALINEAR SCALING BEHAVIOR AND PERMEABILITY/SELECTIVITY DISBALANCE OF IONIC TRANSPORT IN NANOCHANNELS MODULATED BY OUTER-SURFACE CHARGES. Laidy Maidel Alvero González , Deborah Aurora Perini, Marcel Aguilella-Arzo, Lucie A. Bergdoll, Maria Queralt Martin, Antonio Alcaraz 613-Pos Board B397 VOLTAGE SENSING AND ENERGETIC DEMANDS IN VSP. Caleb S. Amann 614-Pos Board B398 CRYOEM STRUCTURE OF THE HUMAN THIK-1 K2P K + CHANNEL REVEALS AND LOWER ‘Y-GATE’ REGULATED BY LIPIDS AND ANAESTHETICS. Ste phen J. Tucker 615-Pos Board B399 MARKOV STATE MODELS OF CONDUCTION AND SELECTIVITY IN INAC TIVATING AND NON-INACTIVATING KCSA CHANNELS. Diego Gazzoni , Carmen Domene, Simone Furini 616-Pos Board B400 TWISTING MOTION OF A SINGLE KCSA CHANNEL IN RESPONSE TO SEQUENTIAL CHEMICAL STIMULI. Yusuke Asasgoe , Yoshikazu HIRAI, Hirofumi Shimizu Heijman 611-Pos

617-Pos Board B401 DYNEIN LIGHT CHAINS 1 AND 2 ARE NOVEL AUXILIARY PROTEINS OF PH-SENSITIVE KIR4.1 CHANNELS. Jian Gao, Ellen T. Thompson, Jonathan Mount, Colin G. Nichols, Sun Joo Lee 618-Pos Board B402 TYROSINE KINASE-DEPENDENT SUPPRESSION OF KV1.2 CONTAIN ING CHANNELS BY AMYLOID BETA (1-42) PEPTIDE: CRITICAL ROLE OF Y132. Joseph Farley , Dina Jamshidi 619-Pos Board B403 STRUCTURAL DETERMINATION OF HUMAN MG 2+ CHANNEL MRS2 IN A LIPID ENVIRONMENT. Isadora Rocha De Abreu , Louis Tung Faat Lai, Fei Zhou, Doreen Matthies 620-Pos Board B404 CHARACTERIZING THE SUBUNIT STOICHIOMETRY OF LRRC8 CHANNEL ASSEMBLIES IN CELL MEMBRANES USING SINGLE MOLECULE MICROS COPY. Rahul Chadda , Janice L. Robertson, Rajan Sah 621-Pos Board B405 KINETIC MODELING OF NUCLEAR LARGE-CONDUCTANCE CATIONIC CHANNELS. Olesia Lunko , Oleksii Lunko, J. Kevin Foskett 622-Pos Board B406 TRANSPORT OF MOLECULES THROUGH PANNEXIN 1: AN ATOMISTIC PERSPECTIVE. Harshavardhan Chilukuri Savitrinarayana , ZhiGuang Jia, Jianhan Chen 623-Pos Board B407 MICRORNA-1 REGULATES GLUCOSE METABOLISM VIA BIOPHYSICAL MODULATION OF ATP-SENSITIVE POTASSIUM CHANNEL. Feng Tang , Shinsuke Nirengi, Xiaoping Wan, Dandan Yang, Daniela Ponce Balbuena, Lisa Baer, Isabelle Deschenes, Stanford Kristin, Jidong Fu 624-Pos Board B408 DECODING POLYUBIQUITIN REGULATION OF KV7.1 ION CHANNEL FUNCTIONAL EXPRESSION WITH ENGINEERED LINKAGE-SELECTIVE DEUBIQUITINASES. Sri Karthika Shanmugam , Scott A. Kanner, Xinle Zou, Enoch Amarh, Papiya Choudhury, Rajesh Soni, Robert S. Kass, Henry M. Board B409 CHARCOT-MARIE TOOTH DISEASE IS ASSOCIATED WITH LOSS OF HIGH- [CA 2+ ] INHIBITION OF H-IP 3 R-3 CA 2+ RELEASE CHANNEL ACTIVITY. Leah C. Simpson , Sourajit Mukherjee, Xiaonan Cui, Jillian Weissenkampen, Horia Vais, J. Kevin Foskett 626-Pos Board B410 CRYOEM IMAGING OF A TMEM16 SCRAMBLASE IN LIPOSOMES. Zhang Feng , Kaitlin Abrantes, William Rice, Alessio Accardi Anion Channels (Boards B411 - B417) 627-Pos Board B411 DELINEATING THE STRUCTURAL FEATURES OF POLYUNSATURATED FATTY ACIDS REQUIRED TO INHIBIT THE CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A. Crystal Lara Santos , Anne E. Carlson 628-Pos Board B412 DOWN-REGULATION OF IL-10 BY LRRC8A CL - CHANNEL INHIBITION THROUGH NRF2 SIGNALING PATHWAY IN TAM-LIKE M 2 MACRO PHAGES. Susumu Ohya , Miki Matsui, Junko Kajikuri, Hiroaki Kito 629-Pos Board B413 VOLUME-REGULATED ANION CHANNEL BLOCKERS ALTER INTRACEL LULAR CALCIUM SIGNALING. Sara T. Granados , Richard Song, Axel Concepcion Colecraft 625-Pos

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