BPS2025 Full Program

630-Pos Board B414 PROBING THE STRUCTURAL BASIS OF RECIPROCAL EFFECTS OF PH AND CHLORIDE ON CLC-6 AND CLC-7 TRANSPORT CURRENTS. Maria Antoni etta Coppola, Abraham Tettey-Matey, Michael Pusch, Peying Fong 631-Pos Board B415 ESYT1 UNDERLIES ER-PM JUNCTIONS FOR ANO1 ACTIVITY AND STORE OPERATED CA2 + ENTRY IN SENSORY NEURONS. Char Palfrey, Mark S. Shapiro, Nikita Gamper, Shihab S. Shah 632-Pos Board B416 DRUG BLOCK NEAR LIPID-BINDING FENESTRAE IN LRRC8/VOLUME-REG ULATED ANION CHANNELS (VRACS). Toshiki Yamada , Paola Bisignano, Erkan Karakas, Jerod S. Denton 633-Pos Board B417 PI(4,5)P 2 PARTICIPATES IN THE VOLTAGE-DEPENDENT ACTIVATION OF TMEM16A VIA TWO BINDING SITES. Ana Elena Lopez-Romero , Jorge Arreola Skeletal Muscle Mechanics, Structure, and Regulation (Boards B418 - B428) 634-Pos Board B418 DYNAMIC SWITCHING OF Β-CARDIAC MYOSIN IN THE SUPER-RELAXED AND DISORDERED-RELAXED STATES TUNES MOTOR PROPERTIES AND IS INSENSITIVE TO MAVACAMTEN. Robert Cail, Faviolla Baez-Cruz, Bipasha Barua, Donald A. Winkelmann, Yale E. Goldman, E. Michael Ostap 635-Pos Board B419 COMPARISON OF IN VIVO MUSCLE CONTRACTILITY AND DENERVATION MARKER EXPRESSION LEVELS IN ALS MOUSE MODEL SOD1G93A. Li Dong , Ang Li, Xuejun Li, Jianxun Yi, Jingsong Zhou 636-Pos Board B420 FORCE-DEPENDENCE REVEALS PHOSPHATE’S EFFECT ON THE CROSS BRIDGE CYCLE, FAVORING A BRANCHED-PATHWAY OVER A POWER STROKE-REVERSAL. Daniel J. Petersen , Christopher Marang, Brent Scott, Edward P. Debold, Sam Walcott 637-Pos Board B421 ALTERED PERINUCLEAR CYTOSKELETON AND LAMINA IN AGED MYONU CLEI: IMPLICATIONS FOR IMPAIRED MECHANORESPONSIVENESS. Osman Esen , Leander Vonk, Sanna Luijcx, Tyler Kirby 638-Pos Board B422 MECHANICALLY TUNABLE MICROENVIRONMENT DEVELOPED BY LAYERS OF HEPARIN AND COLLAGEN FOR IN VITRO CYTOSKELETAL STUDY. Rupesh Kandel , Laurel Fishburn, Victoria Amari, Jorge Almodo var, Dana N. Reinemann 639-Pos Board B423 A MODEL OF PEVK ELASTICITY BASED ON THE RELATIVE ABUNDANCE OF INDIVIDUAL AMINO ACIDS. Kit Bennett , Jenna Monroy, Matthew Gage, Sarah Marzen 640-Pos Board B424 TITIN’S PEVK DOMAIN MODULATES ACTIN POLYMERIZATION. Áron Al torjay, Hedvig Tordai, Ádám Zolcsák, Nikoletta Kosa, Miklós Kellermayer 641-Pos Board B425 IMPACTS OF PH FLUCTUATIONS ON THE STRUCTURE AND BINDING IN TERACTIONS OF TITIN. Sabrina I. Apel, Sudarshi Premawardhana, Sophia Manukian, Mary Harutyunyan, Matthew Gage 642-Pos Board B426 THE SPATIAL ORGANIZATION OF MYBP-C FUNCTIONAL TYPES INFLU ENCES CONTRACTILE PROPERTIES. Thomas Kampourakis, Kenneth S. Campbell

643-Pos Board B427 CROSS-SCALE CONUNDRUM: SLOW MASTICATORY MYOSIN IN JAW MUSCLES THAT ARE BOTH FAST AND STRONG. Varun V. Dhorajia , Nicho las LaFave, Brandon Reder, Robert Brocklehurst, Nicolai Konow, Sam Walcott, Jeffrey R. Moore 644-Pos Board B428 MYOSIN BINDING PROTEIN-C ISOFORMS SELECTIVELY REGULATE MUS CLE TRANSIENT RESPONSES TO STRETCH IN CARDIAC AND SKELETAL MUSCLE. Nichlas M. Engels , Rachel Sadler, Angela Greenman, Samantha Harris Smooth Muscle Mechanics, Structure, and Regulation (Boards B429 - B432) 645-Pos Board B429 EFFECTS OF COERCIVE DISTENSIVE LOADING (CDL) TO SPASTIC INTES TINE (SI) ON EXPRESSIONS OF HEAT SHOCK PROTEINS (E-HSPS). Youngho Lee, Hyeyeong Song, Seungyun Oh, Inyeop Na, Jiwoo Jang, Junghwa Hong 646-Pos Board B430 ANALYSIS OF THE FULL LENGTH OF P63RHOGEF-LIKE PROTEIN, ICHIRO, IN ZEBRA FISH: IS IT THE ZEBRA FISH COUNTERPART OF MAMMALIAN P63RHOGEF? Riyo Kajimoto , Yukari Tanae, Akari Morishita, Haruna Takatsuki, Syunsuke Shimokawa, Akane Watanabe, Masaya Hirota, Natsuho Moriyama, Ko Momotani, Kumiko Sakai 647-Pos Board B431 Travel Award Winner P63RHOGEF: A POTENTIAL THERAPEUTIC TARGET FOR HYPERTENSION TREATMENT. Yukari Tanae , Riyo Kajimoto, Akari Morishita, Haruna Takatsuki, Syunsuke Shimokawa, Akane Watanabe, Masaya Hirota, Natsuho Moriyama, Ko Momotani, Kumiko Sakai 648-Pos Board B432 INTEGRATIVE GENOMIC AND BIOCHEMICAL PROFILING OF HEART FAILURE SPECIMENS AT THE UNIVERSITY OF KENTUCKY. Austin Minton , Austin G. Wellette-Hunsucker, Utku Gulbulak, Gregory Milburn, Andrew Yackzan, Kenneth S. Campbell Microtubules, Structure, Dynamics, and Associated Proteins (Boards B433 - B455) 649-Pos Board B433 PRC1: LIQUID-LIQUID PHASE SEPARATION AND EFFECTS ON MICROTU BULE ORGANIZATION. Julia F. Bourdeau , Prashali Chauhan, Jennifer L. Ross 650-Pos Board B434 SPATIAL REGULATION OF TAU-MICROTUBULE NETWORKS: ACTIVE DYNAMICS REVEALED BY TESSELLATION ANALYSIS. Chaelin Lee-Eom , Jaehun Jung, Celine Park, Min Ju Shon 651-Pos Board B435 Travel Award Winner INVESTIGATING THE ALLOSTERIC EFFECTS OF TAU ON TUBULIN USING ALL-ATOM SIMULATIONS AND MACHINE LEARNING. Jacob Stump , Kas sandra M. Ori-McKenney, Ruxandra I. Dima 652-Pos Board B436 REGULATION OF MICROTUBULE LATTICE COMPACTION BY DOUBLECOR TIN. Regina L.A. Agulto , Yusheng Shen, Kassandra M. Ori-McKenney 653-Pos Board B437 MICROTUBULES SOFTEN ON THE SUB-MILLISECOND TIMESCALE UNDER COMPRESSIVE FORCE. Yasuharu Takagi, Keir C. Neuman, Jing Xu

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