BPS2025 Full Program

Biopolymers in vivo (Boards S20 – S25)

Board S32 MOLECULAR DYNAMICS SIMULATIONS OF THE LIPID-II INTERACTIONS AND ASSEMBLY OF NISIN CHAINS IN BACTERIAL MEMBRANES Hugo A. Perez (120-FlashTalk / 325-Pos / B109) Board S33 ELUCIDATING THE MOLECULAR AND STRUCTURAL MECHANISMS OF A TRPA1 CHANNELOPATHY Isabel Romov (2174-Pos / B368) Board S34 SYNTHETIC MODULATOR RESCUES GATING DEFICITS IN GLUN1 Y647 DISEASE-RELATED NMDA RECEPTOR VARIANTS Samantha R. Schwarz (1245-Pos / B352) Board S35 THE EFFECT OF NATURAL LITHIUM AND LITHIUM ISOTOPES ON VOLT AGE‐GATED SODIUM CHANNEL ACTIVITY IN SH-SY5Y AND IPSC-DERIVED CORTICAL NEURONS Irina Bukhteeva (573-Pos / B357) Board S36 CROSSTALK BETWEEN PHOSPHOINOSITIDE, CHOLESTEROL, AND MEM BRANE TRANSPORTER ABCA1 IN CARDIOVASCULAR DISEASE Mariam Khan (1380-Pos / B387) Board S37 SELECTIVE ENHANCEMENT OF NAV1.5 OPENING OVER FAST INACTIVA TION BY LOSS OF A SINGLE METHYL GROUP IN A CPVT-ASSOCIATED VARIANT Serena Pozzi (548-Pos / B332) Board S38 ROLE OF THE HV1 PROTON CHANNEL IN VASCULAR SMOOTH MUSCLE CELLS Katinka Gyuris (1400-Pos / B407) Board S39 STRUCTURAL EFFECT OF PORE-FACING GLYCOSYLATION ON SYNAPTIC GABAA RECEPTOR Amin Akbari Ahangar (1338-Pos / B345) Board S40 MICROSCALE THERMOPHORESIS: A POWERFUL METHODOLOGY TO MEASURE POTASSIUM CHANNELS ION BINDING SITES DISSOCIATION CONSTANTS Megan Skains (2881-Pos / B345) Board S41 ELUCIDATING THE EFFECTS OF DISEASE-ASSOCIATED MUTATIONS FOR FAST INACTIVATION IN VOLTAGE-GATED SODIUM CHANNELS Shiva Akhlaghi (569-Pos / B353) Board S42 CHARACTERIZATION OF SEVEN NEW K+ CHANNEL BLOCKER PEPTIDES OF CENTRUROIDES BONITO REVEALED α-KTX 2.24 HAS A PICOMOLAR AFFINITY FOR KV1.2 Kashmala Shakeel (2867-Pos / B331) Board S43 ENHANCED KV7.2 CHANNEL ACTIVITY CAN LEAD TO HYPEREXCITABILITY Moses Kamwela (584-Pos / B368) Board S44 CHOLESTEROL REGULATES THE CLUSTERING OF BK CHANNELS Jessica M. Huang (598-Pos / B382)

F R I D A Y

S U N D A Y

Board S20 INVESTIGATING α-SYNUCLEIN LIQUID CONDENSATES TRANSITION TO AN IRREVERSIBLE AGGREGATED STATE Irina A. Edu (375-Pos / B159) Board S21 INVESTIGATING THE ROLE OF SEQUENCE PATTERNING IN THE MIXING OF POLYMER DENSE PHASES Lydia Good (372-Pos / B156) Board S22 EFFECTS OF HYDROPHOBIC SEQUENCE PATTERNS ON THE DISORDERED CONFORMATIONAL ENSEMBLES OF FOLDABLE PROTEINS Cedrick Mukinay (1120-Pos / B127) Board S23 ADVANCED IMAGING OF RIBOSOMAL ASSEMBLY AND RRNA OPERON ORGANIZATION IN E COLI VIA MINFLUX Sijin Chen (815-FlashTalk / 399-Pos / B183) Board S24 EXPLORING PROTEIN STRUCTURE AND DYNAMICS AT BIRTH IN THE PRESENCE OF MOLECULAR CHAPERONES Neomi Millan (381-Pos / B165) Board S25 DECOUPLING PHASE SEPARATION AND FIBRILLIZATION PRESERVES BIOCHEMICAL ACTIVITY OF TAU CONDENSATES Tharun Selvam Mahendran (2694-Pos / B158) Channels, Receptors, and Transporters (Boards S26 – S49) Board S26 ENGINEERING NANOBODY-BASED MODULATORS FOR TARGETED DOWNREGULATION OF THE SODIUM-LEAK CHANNEL NALCN Allen L. Hsu (2213-Pos / B407) Board S27 ADAPTATIONS OF HCN CHANNELS CONTRIBUTING TO EXTREME HEART RATE IN HUMMINGBIRDS Martina S. Hunt (2837-Pos / B301) Board S28 WHEN & WHERE: TRPA1 TRAFFICKING AND TURNOVER Camila Garcia (2165-Pos / B359) Board S29 DELINEATING THE STRUCTURAL FEATURES OF POLYUNSATURATED FATTY ACIDS REQUIRED TO INHIBIT THE CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A Crystal Lara Santos (627-Pos / B411) Board S30 DISSECTING THE MOLECULAR MECHANISM OF TSE4 TOXICITY IN P. AERUGINOSA TARGET MEMBRANES Jessica Rojas-Palomino (1221-Pos / B228) Board S31 SPATIAL COMPARTMENTALIZATION OF EXPRESSION OF THE CAM GENES SUPPORTS VERSATILE CA²⁺-CAM SIGNALING IN CARDIAC MYOCYTES Vladimir Bogdanov (527-Pos / B311)

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