BPS2025 Full Program

Intrinsically Disordered Proteins (Boards S56 – S63)

Board S45 A BI-DIRECTIONAL BINDING SITE LINKING α2δ-1 SUBUNIT TO VOLTAGE SENSOR GATING CHARGES REGULATES THE ACTIVATION KINETICS OF CAV1.1 CALCIUM CHANNELS Martin C. Heiss (2157-Pos / B351) Board S46 CHARACTERIZATION OF AN OPEN-STATE GABAA RECEPTOR USING IN SILICO MUTAGENESIS AND MOLECULAR DYNAMICS SIMULATIONS Ayobami Diyaolu (2183-Pos / B377) Board S47 ELUCIDATING MOLECULAR MECHANISMS OF GATING REGULATION BY N-GLYCOSYLATION IN VOLTAGE-GATED SODIUM CHANNELS Eslam Elhanafy (570-Pos / B354) Board S48 INVESTIGATION OF THE EARLY ACTIVATION STAGE OF CHR2 USING MO LECULAR DYNAMICS SIMULATIONS Kenta Shobu (1100-Pos / B107) Board S49 CONFORMATIONAL DYNAMICS OF THE BINDING POCKET REVEAL THE STATE-DEPENDENT HERG CHANNEL BLOCKADE BY DIVERSE DRUG COMPOUNDS Ramya Bandarupalli (2484-FlashTalk / 1334-Pos / B341) Cryo-EM (Boards S50 – S55) Board S50 DECODING THE MECHANISM OF IRON PIRACY IN PATHOGENIC NEIS SERIA Shubham Dubey (2615-Pos / B79) Board S51 MECHANISMS OF DYSFERLIN-MEDIATED MEMBRANE REPAIR IN HEALTH AND DISEASE Hsiang-Ling Huang (2602-Pos / B66) Board S52 INVESTIGATING THE TRANSMEMBRANE PROTEIN STRUCTURE IN NATIVE CELL MEMBRANES USING CRYO-EM Tzu tzu Liu (2975-Pos / B439) Board S53 TARGETING THE VD4 EPITOPE OF CHLAMYDIA TRACHOMATIS FOR UNIVERSAL VACCINE DEVELOPMENT: STRUCTURAL AND DYNAMIC INSIGHTS Maryam Foroozmehr (245-Pos / B29) Board S54 BASEHUNTER, A NEW APPROACH TO DETERMINING DNA SEQUENCE IN CRYO-ELECTRON MICROGRAPHS, REVEALS DNA-SEQUENCE DEPENDENT CAPTURE OF GYRASE Haley R. Johnson (2978-Pos / B442) Board S55 POXVIRUS MODIFICATION OF HOST RIBOSOMES CONFERS A SELECTIVE TRANSLATIONAL ADVANTAGE TO VIRAL MRNA Aaron Ferrell (385-Pos / B169)

F R I D A Y

S U N D A Y

Board S56 MULTIFUNCTIONAL TRIPHENYLAMINE-BASED THERAPEUTIC PROBES AS INHIBITORS OF AMYLOID AGGREGATION IN ALZHEIMER’S DISEASE Priyam Ghosh (1060-Pos / B67) Board S57 INTERACTION OF HUMAN HNRNPA1 WITH SARS-COV-2 NUCLEOCAPSID PROTEIN AND ITS IMPLICATIONS FOR VIRAL RNA BINDING Parul Gupta (1139-Pos / B146) Board S58 MICROPHASE VERSUS MACROPHASE SEPARATION OFPROTEINS WITH RNA RECOGNITION MOTIFS Vicky Liu (371-Pos / B155) Board S59 INFLUENCE OF CHARGE SEGREGATION AND CHAIN LENGTH ON THE MATERIAL PROPERTIES OF BIOMOLECULAR CONDENSATES Keerthivasan Muthukumar (2654-Pos / B118) Board S60 THE DYNAMIC INTERPLAY OF STABILITY AND FLEXIBILITY: UNRAVELING THE ROLE OF PSEUDOKNOT 1 IN TMRNA TRANS-TRANSLATION Karim O. Malekzadeh (2008-Pos / B202) Board S61 CONSTRUCTION OF IDR ENSEMBLES DIRECTLY FROM SEQUENCE THROUGH MULTI-SCALE GENERATIVE MODELING Borna Novak (2649-Pos / B113) Board S62 GENERATIVE AND SUPERVISED PREDICTION OF ARTIFICIAL INTRINSI CALLY DISORDERED PROTEIN SEQUENCES FORMING BIOMOLECULAR CONDENSATES Youmin Shim (1122-Pos / B129) Board S63 DESIGNING PEPTIDES WITH OPTIMIZED PARAMETERS USING MONTE CARLO MOVES Arjun Singh (1123-Pos / B130) Macromolecular Machines and Assemblies (Boards S64 – S77) Board S64 DEVELOPING A METHOD FOR SCREENING INHIBITORS OF RFC-DEPEN DENT TERMINATION OF PROTEIN SYNTHESIS AT PTCS Adam A. Jabak (382-Pos / B166) Board S65 ASSEMBLY OF THE BACTERIAL RIBOSOME WITH CIRCULARLY PERMUTED 23S RNA Xiyu Dong (391-Pos / B175) Board S66 PHASE-SEPARATED AQUEOUS POLYELECTROLYTE SOLUTIONS AS “PROTO-CYTOPLASM” AND THEIR RESPONSE TO GUEST MOLECULES AND ENVIRONMENTAL PERTURBATIONS Jiaqi Pei (1973-Pos / B167)

54