BPS2025 Full Program

Platform Protein-Small Molecule Interactions I 8:15 am - 10:15 am, Room 502B

Platform Mechanosensation, Endocytosis, and Exocytosis 8:15 am - 10:15 am, Room 501ABC Co-Chairs Veronica Jimenez, California State University, Fullerton, USA Shefin Sam George, Stanford University, USA 847-Plat 8:15 am THE ENDOPLASMIC RETICULUM: A KEY MECHANOTRANSDUCER OF THE HIPPO SIGNALING PATHWAY. Benjamin Ravaux 848-Plat 8:30 am MICROENVIRONMENTAL MECHANICAL REGULATE CHROMATIN AR CHITECTURE AND CELL FATE IN LUNG FIBROSIS. Ramin Basir , Vinayak Vinayak, Vivek B. Shenoy 849-Plat 8:45 am Travel Award Winner PIEZO1 CHANNEL-MEDIATED MECHANOTRANSDUCTION AS A DRIVER OF CARDIAC FIBROSIS. Jinyuan V. Li , Scott Kesteven, Delfine Cheng, Michael Laden, Farzaneh Omidkhoda, Vaibhao Janbandhu, Vikram Tal lapragada, Bharti Shewale, Michael Fneley, Richard P. Harvey, Charles D. Cox 850-Plat 9:00 am MECHANOSENSITIVE CHANNELS AS MOLECULAR DETERMINANTS OF PARASITE SURVIVAL AND INFECTIVITY IN TRYPANOSOMA CRUZI . Irin Ploypray, Jorge Rincon, Veronica Jimenez 851-Plat 9:15 am ACTIVATION OF TMEM16E SCRAMBLASE INDUCES LIGAND-INDEPEN DENT GROWTH FACTOR RECEPTOR SIGNALING AND MACROPINOCYTO SIS FOR MEMBRANE REPAIR. Jung-Eun Kim , Jin-nyeong Woo, Byung C. Suh 852-Plat 9:30 am ULTRAFAST ENDOCYTOSIS IS ACTIVATED BY A DYNAMIC MEMBRANE RESERVOIR MECHANICALLY REGULATED BY MEMBRANE TENSION, CORTICAL ADHESION AND RELEASE SITE AVAILABILITY. Yingwen Huang , Dong An, Rui Su, Lisi Wei, Chung Yu Chan, Ling-Gang Wu, Ben O’Shaughnessy 853-Plat 9:45 am THE AUDITORY HAIR CELL MECHANOTRANSDUCTION COMPLEX DY NAMICALLY REGULATES STEREOCILIA MEMBRANE MECHANICS. Shefin Sam George , Anthony J. Ricci 854-FlashTalk 10:00 am STRETCHING TIP LINKS AT THE SPEED OF SOUND: COARSE-GRAINED SIMULATIONS OF A PROTEIN FILAMENT ESSENTIAL FOR HEARING. Harper Smith , Carter T. Wheat, Jasanvir S. Sandhu, Elakkiya Tamilselvan, Pedro De-la-Torre, Joseph C. Sudar, Travis Harrison-Rawn, Marissa Boyer, Qurat Ashraf, Haosheng Wen, Daisy Alvarado, Marcos M. Sotomayor 855-FlashTalk 10:05 am MULTIPLE CONFORMATIONAL STATES OF ASSEMBLED DYNAMIN LEAD TO MEMBRANE FISSION. Nidhi Kundu , Sarah B. Nyenhuis, John Jimah, Bertram J. Canagarajah, Jenny E. Hinshaw 856-FlashTalk 10:10 am MECHANISMS OF VIRUS BUDDING THROUGH CELLULAR MEMBRANES. Shuyang Zhang , Siyu Li, Ajay Gopinathan, Paul van der Schoot, Roya Zandi

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Co-Chairs Angela Lackner, University of California, Irvine, USA Andrew Stephen, Frederick National Laboratory for Cancer Research (FNLCR), USA 837-Plat 8:15 am Travel Award Winner MECHANISTIC INSIGHTS AND BIOPHYSICAL APPROACHES FOR DISRUPT ING RESPIRATORY SYNCYTIAL VIRUS (RSV) REPLICATION MACHINERY. Stepanka Nedvedova , Xiaosong Liu, Origène Nyanguile, Olivier Speran dio, Marie Galloux, Christina Sizun 838-Plat 8:30 am DISRUPTING RESISTANCE: A NOVEL INHIBITOR TARGETING ANTIMICRO BIAL EFFLUX. Tania Szal , Emmanouela Petsolari, Janis Veliks, Cristina D. Cruz, Laura Paunina, Marina Madre, Fatima-Zahra Rachad, Philipp Lewe, Susanne Witt, Päivi Tammela, Aigars Jirgensons, Ben F. Luisi, Björn Windshügel 839-Plat 8:45 am Travel Award Winner STRUCTURAL AND MECHANISTIC INSIGHTS INTO CABOTEGRAVIR RESIS TANCE IN HIV-1 INTEGRASE. Indrani Choudhuri , Tao Jing, Avik Biswas, Min Li, Steven Smith, Robert Craigie, Eric O. Freed, Terrence R. Burke, Jr., Stephen Hughes, Ronald M. Levy, Dmitry Lyumkis 840-Plat 9:00 am Travel Award Winner TARGETING THE NLRP3 PYRIN DOMAIN: NOVEL INHIBITORS THAT BLOCK INFLAMMASOME ACTIVATION VIA OXIDIZED DNA. Angela Lackner , Lemuel Leonidas, Alijah Macapagal, Hannah Lee, Huilin Xu, Reginald 9:15 am EXPLORING GLYCOGEN SYNTHASE KINASE 3Β (GSK3Β) LIGANDS AS PO TENTIAL COMPOUNDS FOR TARGETED THERAPY IN CANCER PATIENTS. Neha Walter, Sanchit Dora, Jasmeet Kaur 842-Plat 9:30 am BIOPHYSICAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS BINDING TO KRAS. Andrew G. Stephen , Patrick Alexander, Monalisa Swain, Dana Rabara, Erik K. Larsen 843-Plat 9:45 am STRUCTURAL DETERMINANTS OF AGONIST AND ANTAGONIST EFFECTS AT THE CANNABINOID RECEPTORS. Elizabeth D. Oke , Ayobami Diyaolu, Pinaki Bhattacharjee, Malliga Iyer, Senthil Natesan 844-FlashTalk 10:00 am COMPARATIVE MOLECULAR MODELING AND SIMULATIONS OF BETA ADRENERGIC RECEPTOR-DRUG INTERACTIONS. Kyle C. Rouen , Nancy Daoud, Yanxiao Han, Igor Vorobyov 845-FlashTalk 10:05 am HOW DOES MRS7292 STABILIZE THE OUTWARD-FACING STATE OF THE HUMAN DOPAMINE TRANSPORTER? INSIGHTS FROM COMPUTATIONAL BIOPHYSICS. Md Fulbabu Sk , Dushyant Kumar Srivastava, Dilip K. Tosh, Audrey Chinn, Kenneth A. Jacobson, Eric Gouaux, Emad Tajkhorshid 846-FlashTalk 10:10 am IN SILICO SCREENING TO TARGET CALPAIN HETERODIMERIZATION WITH SMALL MOLECULES: POTENTIAL DRUGS TO MODULATE CALPAIN ACTIV ITY. Pitambar Poudel , Ivan Shapovalov, Shailesh Kumar Panday, Peter A. Greer, Emil Alexov McNulty 841-Plat

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