Biophysical Society 2020 Annual Meeting

958-Pos Travel Awardee EFFECT OF NASCENT PROTEINS ON THE STABILITY OF THE RIBOSOME. Meranda M. Masse , Angela E. Varela, Aniruddha Srivastava, Silvia Cavag- nero 959-Pos Board B27 ENHANCED SENSITIVITY TO LOCAL DYNAMICS IN PEPTIDES BY USE OF TEMPERATURE-JUMP IR-SPECTROSCOPY AND ISOTOPE LABELING. David Scheerer, Heng Chi, Dan McElheny, Tim A. Keiderling , Karin Hauser 960-Pos Board B28 DISORDER-TO-ORDER TRANSITIONS AND POST-TRANSLATIONAL ACYLA- TION CONTROL THE FOLDING AND ACTIVITY OF THE BORDETELLA PERTUSSIS CYAA TOXIN. Darragh P. O’Brien, Alexis Voegele, Dorothée Raoux-Barbot, Marilyne Davi, Sara Cannella, Thibaut Douché, Mariette Matondo, Dominique Durand, Patrice Vachette, Sébastien Brier, Daniel Ladant, Alexandre Chenal 961-Pos Board B29 COMPUTATIONAL ANALYSIS OF MISSENSE MUTATIONS IN CREATINE TRANSPORTER PROTEIN ASSOCIATED WITH CREATINE DEFICIENCY SYN- DROME. Mahesh Koirala , Emil Alexov 962-Pos Board B30 ROLE OF ZERO-ORDER LOOP IN PROTEIN UNFOLDING CASE STUDY WITH APOAZURIN. Dirar M. Homouz , Fabio Zegarra, Pernilla E. Wittung- Stafshede, Margaret S. Cheung 963-Pos Board B31 CATALYSIS OF AGGREGATION BY INTERFACE OPENING AND DISULFIDE EXCHANGE IN CATARACT-ASSOCIATED VARIANTS OF HUMAN GAMMA- D CRYSTALLIN. Eugene Serebryany , WilliamM. Jacobs, Rostam Razban, Eugene Shakhnovich 964-Pos Board B32 SINGLE-MOLECULE FORCE SPECTROSCOPY REVEALS THE MECHANICAL DESIGN GOVERNING THE EFFICIENT TRANSLOCATION OF BACTERIAL TOXIN PROTEIN RTX. Han Wang , Xiaoqing Gao, Hongbin Li 965-Pos Board B33 DETAILS OF THE CONFORMATIONAL CYCLE OF HSP90 PROBED USING OPTICAL TWEEZERS. Katarzyna Tych , Markus Jahn, Hannah Girstmair, Thorsten Hugel, Johannes Buchner, Matthias Rief 966-Pos Board B34 BREAKTHROUGH EMPIRICAL APPROACH TO DETERMINING DEAMIDA- TION SITES AND ASSESSING PROTEIN STABILITY FOR AN ARRAY OF THERAPEUTIC PROTEINS IN SOLUTION. Belinda Pastrana-Rios 967-Pos Board B35 THERMOSTABILITY OF THE ENGRAILED HOMEODOMAIN AND AN EN- GINEERED VARIANT. Natali A. Gonzalez , Emily Hamlin, Parwana Khazi, Michelle E. McCully 968-Pos Board B36 ENERGY LANDSCAPE OF UBIQUITIN FAMILY PROTEINS - ELUCIDATING THE ROLE OF PROTEIN SEQUENCE AND SPECIFIC INTERACTIONS SUCH AS SALT-BRIDGES IN DICTATING FOLDING PATHWAYS. Tathagata Nandi , Sri Rama Koti Ainavarapu 969-Pos Board B37 IS DODINE A PROTEIN STABILIZER OR DESTABILIZER? IT’S COMPLICAT- ED! Shriyaa Mittal , Drishti Guin, Brian Bozymski, Diwakar Shukla, Martin Gruebele 970-Pos Board B38 TRADEOFF BETWEEN THERMOSTABILITY AND DNA-BINDING FUNCTION IN ENGINEERED VARIANTS OF ENHD. Lauren Verheyden, Lily A. Schumacher , Andrew T. Bigler, Michelle E. McCully Board B26

971-Pos Board B39 AMPHIPHILIC COPOLYMER INHIBITION OF PNIPAM-PS AGGREGATION IS HLB DEPENDENT. Michelle X. Ling , Jeff M. Ting, Amanda B. Marciel, Mat- thew V. Tirrell, Raphael C. Lee 972-Pos Board B40 DESMIN FORMS TOXIC, SEEDING COMPETENT AMYLOID AGGREGATES THAT PERSIST IN MUSCLE FIBERS. Niraja Kedia, Khalid Arhzaouy, Sara Pitt- man, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, Jan Bieschke Protein Assemblies I (Boards B41 - B67) 973-Pos Board B41 ENGINEERING TEMPERATURE SENSITIVE ALLELES INSACCHAROMYCES CEREVISIAETO STUDY THE GENETIC INTERACTIONS BETWEEN RAN POINT MUTANTS AND ITS ACCESSORY PROTEINS. Tenzin Tsepal 974-Pos Board B42 ATOMIC FORCE MICROSCOPY IN THE STUDY OF PROTEIN SELF-ASSEM- BLY. Natalia V. Kuzmina , Evgeniy V. Dubrovin, Olga N. Koroleva, Valeriy L. Drutsa, Joshua Zimmerberg, Oleg V. Batishchev 975-Pos Board B43 UNCOVERING THE SELF-ASSEMBLY MECHANISM OF HEPATITIS B VIRUS AT THE SINGLE-MOLECULE LEVEL. Pedro Buzón , Sourav Maity, Panagiotis Christodoulis, Monique J. Wiertsema, Steven Dunkelbarger, Christine Kim, Gijs J. Wuite, Adam Zlotnick, Wouter H. Roos 976-Pos Board B44 Travel Awardee SINGLE-MOLECULE MECHANICAL MEASUREMENTS OF THE HYALURO- NAN-AGGRECAN BOTTLEBRUSH. Sarah N. Innes-Gold , John P. Berezney, Omar A. Saleh 977-Pos Board B45 QUANTITATIVE MASS SPECTROMETRIC ASSAY OF AMYLOID BETA PEPTIDE VARIANTS WITH N- AND C-TERMINAL TRUNCATIONS AND MODIFICA- TIONS IN HUMAN BRAIN. Ran Furman, Sharon C.W. Ng, Hiroaki Komatsu , Paul H. Axelsen 978-Pos Board B46 INTEGRATIVE STRUCTURAL BIOLOGY OF BACTERIAL NANO-MA- CHINES. Nadia Izadi Pruneyre 979-Pos Board B47 MAPPING THE EMERIN INTERACTOME BY APEX PROXIMITY LABEL- ING. Markville B. Bautista , Fabien Pinaud 980-Pos Board B48 UTILIZING 3D PRINTING FOR ENHANCED SAMPLE HANDLING IN ANALYTI- CAL ULTRACENTRIFUGATION. Samuel C. To , Chad Brautigam, Sumit K. Chaturvedi, Mary T. Bollard, Jonathan Krynitsky, John Kakareka, Tom Pohida, Huaying Zhao, Peter Schuck 981-Pos Board B49 PLASTICITY IN PROTEIN SEQUENCE-FUNCTION RELATIONSHIPS.  Chenlu He , Dorothy Beckett 982-Pos Board B50 CELLULAR GAG-CONTAINING COMPLEXES AND HIV ASSEMBLY.  Yisong Deng , John A. Hammond, Raymond F. Pauszek, Ilean Chai, Stosh T. Ozog, David P. Millar, Bruce E. Torbett, James R. Williamson 983-Pos Board B51 PHYSIOLOGICALLY-RELEVANT CROWDING EFFECTS ON THE SH3-SON OF SEVENLESS INTERACTION. Samantha S. Stadmiller , Jhoan Sebastian Aguilar, Gary J. Pielak

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