Biophysical Society 2020 Annual Meeting

2053-Pos Board B323 ARRHYTHMOGENIC MECHANISMS IN HIPSC-CMS DERIVED FROM PA- TIENTS WITH DUCHENE MUSCULAR DYSTROPHY.  Eric N. Jiménez-Vázquez 2054-Pos Board B324 PERMEATION PROPERTIES OF PURIFIED PANNEXIN 1 CHANNELS IN PROTEOLIPOSOMES. Adishesh K. Narahari , Alex J. Kreutzberger, Susan Leonhardt, Xueyao Jin, Pablo Pauchard, Christopher B. Medina, Volker Kiessling, Kodi Ravichandran, Jorge E. Contreras, Lukas K. Tamm, Mark Yeager, Douglas A. Bayliss 2055-Pos Board B325 EFFECTS OF CATION BINDING TO THE INTRACELLULAR VESTIBULE OF TMEM16 ION TRANSPORT PATHWAYS. Dung M. Nguyen , Tsung-Yu Chen 2056-Pos Board B326 EFFECTS OF PIP2 BINDING TO ITS DIFFERENT BINDING SITES ON ANO1 FUNCTION. Kuai Yu , Tao Jiang, Yuanyuan Cui, Emad Tajkhorshid, H. Criss Hartzell 2057-Pos Board B327 CAMP-INDUCED CONFORMATIONAL CHANGES IN THE C-LINKER OF HCN4. Bianca Introini , Andrea Saponaro, Alessio Bonucci, Oliver Rauh, Francesca Cantini, Lucia Banci, Gerhard Thiel, Anna Moroni 2058-Pos Board B328 ACTIVATION MECHANISM OF THE MECHANOSENSITIVE OSCA CHANNEL: A MOLECULAR DYNAMICS STUDY. Dali Wang , Chen Song 2059-Pos Board B329 ROS-DEPENDENT REGULATION OF SOCS IN ADULT RAT CARDIOMYO- CYTES PRECONDITIONED WITH DIAZOXIDE.  Joice T. Gavali , Elba D Car- rillo, Ascención Hernández, Maria C. Garcia, Jorge A. Sanchez 2060-Pos Board B330 Travel Awardee A CLOSER LOOK AT ORAI3: AN INVESTIGATION INTO CONSTITUTIVELY AC- TIVE MUTANTS OF THE LESSER KNOWN CALCIUM ION CHANNEL.  Juliana M. Larson , Robert M. Nwokonko, James H. Baraniak, Yandong Zhou, Donald L. Gill 2061-Pos Board B331 THE MECHANISMS OF UP-REGULATION OF K + CHANNELS IN CD4 + T CELLS OF INFLAMMATORY BOWEL DISEASE. Susumu Ohya , Kyoko Endo, Hiroaki Kito, Junko Kajikuri, Takayoshi Suzuki 2062-Pos Board B332 INVESTIGATION OF PHARMACEUTICAL AGENTS INTERACTION WITH K2P POTASSIUM CHANNELS. Natália M. Oliveira , Werner Treptow, Leonardo Cirqueira, Leticia Stock 2063-Pos Board B333 SIGNALING MECHANISMS UNDERLYING NICOTINE-INDUCED UPREGULA- TION OF Α7 NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR).  Jayharsh Panchal , Mohammad Islam, Kristi DeBoeuf, Joseph Farley 2064-Pos Board B334 Travel Awardee CELLULAR STRESS P38MAPK ACTIVATION DECREASE NAV1.5 CURRENT DENSITY AND CONTRIBUTES TO THE DEVELOP OF ARRHYTHMIA IN ELDERLY. Daniela Ponce Balbuena Cardiac Muscle Mechanics and Structure (Boards B335 - B365) 2065-Pos Board B335 THE ROLE OF ELECTROSTATICS IN THE DESENSITIZATION OF CARDIAC MUSCLE CONTRACTION. Fangze Cai , Ian M. Robertson, Thomas Kam- pourakis, Britney A. Klein, Brian D. Sykes

2066-Pos Board B336 QUANTIFYING CONTRIBUTIONS OF CELLULAR MECHANICAL MYOCAR- DIAL PROPERTIES ON LEFT VENTRICULAR CONTRACTILE FUNCTION IN AORTIC BANDED RATS. Stefano Longobardi , Alexandre Lewalle, Cynthia J. Musante, Anna Sher, Steven A. Niederer 2067-Pos Board B337 DOCKING TROPONIN-T ONTO THE TROPOMYOSIN OVERLAPPING DOMAIN OF THIN-FILAMENTS. Elumalai Pavadai , Michael J. Rynkiewicz, Anita Ghosh, William Lehman 2068-Pos Board B338 SEPARATING THE PRIMARY AND SECONDARY EFFECTS OF SARCOMERIC DYSFUNCTION IN THE EARLY DISEASE PATHOGENESIS OF FAMILIAL HY- PERTROPHIC CARDIOMYOPATHY. Sarah R. Clippinger 2069-Pos Board B339 TARGETING THE MYOSIN OFF-ON EQUILIBRIUM TO MODULATE LENGTH- DEPENDENT CONTRACTION IN HUMAN MYOCARDIAL STRIPS. Peter O. Awinda, Krista M. Brutman, Yemeserach Bishaw, Marissa Watanabe, Maya Guglin, Kenneth S. Campbell, Bertrand C. Tanner 2070-Pos Board B340 EFFECTS OF MAVACAMTEN AND BLEBBISTATIN ON THE SMALL-ANGLE X- RAY SCATTERING STRUCTURE OF HUMAN Β-CARDIAC MYOSIN. Weikang Ma , Suman Nag, Srinivas Chakravarthy, Sampath Gollapudi, Na Sa, Ivan Tomasic, Thomas C. Irving 2071-Pos Board B341 MULTI-DIMENSIONAL MAPPING OF CELL STATES DURING CARDIOMYO- CYTE DIFFERENTIATION USING LIVE IMAGING AND RNA FISH. Melissa Hendershott , Susanne M. Rafelski 2072-Pos Board B342 CROSS-SPECIES DYNAMICS OF MYOSIN IN PRE-POWERSTROKE STATES. Matthew C. Childers , Valerie Daggett, Michael Regnier 2073-Pos Board B343 EFFECT OF MYOSIN ISOFORM ON MECHANICS IN INTACT CARDIAC TRA- BECULAE FROMMICE, RATS AND HUMANS. Srboljub M. Mijailovich , Momcilo Prodanovic, Corrado Poggesi, Michael Regnier, Michael A. Geeves 2074-Pos Board B344 DECOUPLING THE INTERACTING HEAD MOTIF AND THE SUPER RELAXED STATE OF MYOSIN IN RECONSTITUTED CARDIAC BIPOLAR THICK FILA- MENTS. Sampath K. Gollapudi , Na Sa, Suman Nag 2075-Pos Board B345 A HIGH-THROUGHPUT FLUORESCENCE LIFETIME-BASED ASSAY FOR DE- TECTING BINDING OF MYOSIN BINDING PROTEIN-C TO F-ACTIN-TROPO- MYOSIN. Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson 2076-Pos Board B346 MUTATIONS IN THE TNT1 TROPOMYOSIN-BINDING ELEMENT OF TROPO- NIN-T ALTER ITS INHIBITORY PROPERTIES AND STIMULATE MYOCARDIAL DYSFUNCTION. Aditi Madan, Meera C. Viswanathan, Kathleen C. Woulfe, WilliamM. Schmidt, Georg Vogler, Cortney Wilson, Sineej Madathil, Bran- don J. Biesiadecki, Bosco Trinh, Agnieszka Sidor, Ting Liu, Brian O’Rourke, Larry S. Tobacman, Anthony Cammarato 2077-Pos Board B347 DEFINING THE FLEXIBLE CARDIAC TROPONIN T LINKER REGION IN RELA- TIONSHIP TO ACTIN AND DETERMINING EFFECTS OF PATHOGENIC POINT MUTATIONS. Andrea E. Deranek , Anthony Baldo, Catherine Vasquez, Steven D. Schwartz, Jil C. Tardiff

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