Biophysical Society 2020 Annual Meeting

2410-Plat 1:45 pm THE STICKERS AND SPACERS FRAMEWORK FOR DESCRIBING PHASE BEHAVIOR OF MULTIVALENT INTRINSICALLY DISORDERED PROTEINS.  Jeong-Mo Choi , Rohit V. Pappu 2411-Plat 2:00 pm SIZE-DEPENDENT CHARACTERIZATION OF ALPHA-SYNUCLEIN AGGRE- GATES UNVEILS THEIR TOXICITY.  Derya Emin , Margarida Rodrigues, Zengjie Xia, Antonina Kouli, Helen Henson, Caroline Williams-Gray, David 2:15 pm QUANTIFYING THE THERMODYNAMIC STABILITY OF AMYLOID FIBRILS.  Kimberley L. Callaghan , Quentin Peter, Janet R. Kumita, Tuomas P. Knowles, Christopher M. Dobson 2413-Plat 2:30 pm BACKBONE DYNAMICS OF THE TAZ1 DOMAIN OF THE CREB-BINDING PROTEIN MODULATE COMPETITION BETWEEN DISORDERED LIGANDS.  Rebecca B. Berlow , Jane Dyson, Peter E. Wright 2414-Plat 2:45 pm RATIONAL DESIGN OF PEPTIDE TARGETING INTRINSICALLY DISORDERED PROTEIN P53 -REGULATION OF FUNCTION AND PHASE SEPARATION.  Kiyoto Kamagata , Ryo Kitahara, Tomoshi Kameda Platform Cardiac, Smooth, and Skeletal Muscle Electrophysiology and Regulation II 1:00 pm - 3:00 pm, Room 23ABC Klenerman 2412-Plat TARGETED REMUSCULARIZATION CAN REDUCE VENTRICULAR TACHY- CARDIA (VT) BURDEN IN A COMPUTATIONAL HUMAN HEART MODEL OF POST-MYOCARDIAL INFARCTION (MI).  Jialiu A. Liang , Joseph K. Yu, Natalia A. Trayanova 2416-Plat 1:15 pm STRUCTURAL MAPPING OF ACTION POTENTIAL PROPAGATION PATH- WAYS THROUGH HEALTHY AND DISEASED HEART.  Erica Lazzeri, Francesco Giardini, Irene Costantini, Ludovico Silvestri, Raffaele Coppini, Cecilia Ferrantini, Giacomo Mazzamuto, Caroline Muellenbroich, Leslie M. Loew, Leonardo Bocchi, Elisabetta Cerbai, Corrado Poggesi, Martin J. Bishop, Francesco S. Pavone, Leonardo Sacconi 2417-Plat 1:30 pm A NEWMECHANISM OF CELLULAR AND TISSUE AUTOMATICITY.  Steven Poelzing , James P. Keener, Kees McGahan 2418-Plat 1:45 pm SPATIOTEMPORAL MODULATION OF ACTION POTENTIAL DURATION IN INTACT HEARTS BY SUB-THRESHOLDS OPTOGENETICS STIMULATION.  Valentina Biasci , Marina Scardigli, Lorenzo Santini, Raffaele Coppini, Ce- cilia Ferrantini, Caroline Muellenbroich, Leslie M. Loew, Elisabetta Cerbai, Corrado Poggesi, Marfina Campione, Francesco S. Pavone, Leonardo Sacconi 2419-Plat 2:00 pm CREATING ION CHANNEL MODELS WITH UNBIASED GRAPHS.  Kathryn Mangold , Jonathan R. Silva 2420-Plat 2:15 pm EXPLORING THE EFFECTS OF CONDUCTION RESERVE AND EPHAPTIC COUPLING IN CARDIAC CELLS.  Joyce Lin , Steven Poelzing, Sharon A. George, Amara Greer-Short, MatthewW. Kay Co-Chairs Balazs Horvath, University of Debrecen, Hungary Joyce Lin, California Polytechnic State University 2415-Plat 1:00 pm

2421-Plat 2:30 pm INTERPLAY BETWEEN Β-ADRENERGIC STIMULATION AND CAMKII SIGNALING FAVORS HUMAN ATRIAL ARRHYTHMOGENESIS: INSIGHTS FROM POPULA- TIONS OF MODELS.  Haibo Ni , Xianwei Zhang, Stefano Morotti, Eleonora Grandi 2422-Plat 2:45 pm LATE SODIUM CURRENT IN CANINE, GUINEA PIG AND HUMAN LEFT VENTRIC- ULAR MYOCARDIUM.  Balazs Horvath , Tamas Hezso, Norbert Szentandrássy, Kornel Kistamas, Tamas Arpadffy-Lovas, Roland Veress, Csaba B. Dienes, Dora Baranyai, Laszlo Virag, Norbert Nagy, Istvan Baczko, Janos Magyar, Tamas Banyasz, Andras Varro, Peter P. Nanasi Platform Skeletal and Smooth Muscle Mechanics, Co-Chairs Belinda Bullard, University of York, United Kingdom Miklós Kellermayer, Semmelweis University, Hungary 2423-Plat 1:00 pm STRUCTURAL INSIGHTS INTO F-ACTIN REGULATION AND SARCOMERE ASSEM- BLY VIA MYOTILIN.  Kristina Djinovic-Carugo , Julius Kostan 2424-Plat 1:15 pm SAR ANALYSIS OF LINKER DERIVATIVES OF THE SMOOTH MUSCLE MYOSIN SPECIFIC CK-571 COMPOUND.  Sharad K. Suthar, Mate Gyimesi, Csilla Kurdi, Andras Malnasi-Csizmadia 2425-Plat 1:30 pm TROPOMYOSIN AS A STRETCH SENSOR IN THE TROPONIN BRIDGES OF INSECT FLIGHT MUSCLE.  Konstantinos Drousiotis, Demetris Koutalianos, Christoph G. Baumann, Belinda Bullard 2426-Plat 1:45 pm BASIC RESIDUES IN THE C-TERMINAL REGION OF TROPONIN T ARE CRITICAL IN SKELETAL MUSCLE REGULATION.  Alfredo J. Lopez-Davila, Li Zhu, Leon Fritz, Theresia Kraft , Joseph M. Chalovich 2427-Plat 2:00 pm MICROTUBULE REMODELING CONTRIBUTES TO THE LOSS OF FORCE AND POWER IN AGING SKELETAL MUSCLE.  Humberto Cavalcante Joca , Anicca Harriot, Jenna Leser, Andrew Coleman, Guoli Shi, Joseph P. Stains, Christopher W. Ward 2428-Plat 2:15 pm WEAKLY-BOUND, NON-LINEAR ELASTIC CROSS-BRIDGES ARE REQUIRED TO SELF-CONSISTENTLY MODEL THE FENN EFFECT, FORCE VELOCITY AND TEN- SION TRANSIENTS IN MUSCLE FIBERS.  Katelyn Jarvis , Kaylyn Bell, Amy K. Loya, Douglas M. Swank, SamWalcott 2429-Plat 2:30 pm TOPOLOGICAL STRUCTURE OF SMOOTH-MUSCLE TITIN MOLECULES AND OLIGOMERS.  Elmira I. Yakupova, Ivan M. Vikhlyantsev, Alexander G. Bobylev, Zsolt Mártonfalvi, Miklós S. Kellermayer 2430-Plat 2:45 pm THICK FILAMENT ACTIVATION AND POST-TETANIC POTENTIATION MECHA- NISMS EVOLVED DIFFERENTLY IN INVERTEBRATE AND VERTEBRATE STRIATED MUSCLE.  Raul Padron , Weikang Ma, Sebastian Duno Miranda, Natalia Kou- bassova, Kyounghwan Lee, Prince Tiwari, Antonio Pinto, Pura Bolaños, Andrey Tsaturyan, Thomas C. Irving, Roger Craig Structure, and Regulation 1:00 pm - 3:00 pm, Room 24ABC

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