Biophysical Society 62nd Annual Meeting | Program Guide

2054-Pos Board B70 ROLE OF ELECTROSTATIC INTERACTIONS IN LIGAND RECOGNITION BY OROTIDINE-5’-MONOPHOSPHATE DECARBOXYLASE (ODCASE).  Jesi Lee , Trevor Gokey, Weiming Wu, Anton B. Guliaev 2055-Pos Board B71 AN EFFICIENT CELL MODEL FOR SCREENING SMALL MOLECULE AGONISTS OF GLP-1 RECEPTOR. Ni Pi, Xiyao Cheng , Yongqi Huang, Zhengding Su 2056-Pos Board B72 DETERMINATION OF EFFECTOR BINDING AFFINITIES USING PHOTO- ACOUSTIC CALORIMETRY.  Jovany J. Betancourt , Jaroslava Miksovska 2057-Pos Board B73 DISCOVERY OF ZIKA NS5 POLYMERASE INHIBITORS. Anthony F. T. Moore , Board B74 REVERSIBLE COVALENT BINDING AS CONCEPT FOR ALLOSTERIC INHIBI- TION OF HOST CELL INVASION BY MALARIA PARASITES.  Janna Ehlert , Julia Weder, Matthias Preller 2059-Pos Board B75 INTERACTIONS OF NEURONAL CALCIUM SENSOR DREAMWITH ZINC. Maria D. Santiago 2060-Pos Board B76 COMBINATION THERAPIES WITH ANTIMICROBIAL PEPTIDE LL-37 AND CONVENTIONAL ANTIBIOTICS. Mehrnaz A. Siavoshi , Federico I. Prokopc- zuk, Nathan-Alexander Del Rosario, Lannah Abasi, Sattar Taheri-Araghi 2061-Pos Board B77 SOLVATION THERMODYNAMIC PROPERTIES OF CLEANSER SURFACTANTS AND THEIR SKIN HARSHNESS. Manori Jayasinghe 2062-Pos Board B78 BIOPHYSICAL CHARACTERIZATION OF INTERACTIONS OF HEPARIN WITH HIV-1 TAT PEPTIDE 47-57 AND ITS PERTURBATION BY CATIONIC SMALL MOLECULE. Neha Tiwari 2063-Pos Board B79 ISOTHERMAL TITRATION CALORIMETRY AND OXYGEN BINDING STUD- IES BETWEEN INOSITOL HEXAKISPHOSPHATE AND HUMAN HEMOGLO- BIN. Antonio Tsuneshige , Takashi Yonetani 2064-Pos Board B80 MODULATION OF THE CIRCADIAN PERIOD: SEARCHING FOR ISOFORM- SELECTIVE CYCLOPHILIN INHIBITORS. Ali Yousefi, Kiernan Kringen , Ryan Noland, AndrewMcShan, Scott Lokey, Carrie L. Partch 2065-Pos Board B81 NANOSCALE ENCAPSULATION FOR FRAGMENT BASED DRUG DISCOV- ERY. Brian Fuglestad, Nicole E. Kerstetter , Sabrina Bédard, A. Joshua Wand 2066-Pos Board B82 CONSISTENCY CRITERION FOR PARTICLE SORTING IN SINGLE-PARTICLE CRYO-EM. Daniel Asarnow , Yifan Cheng 2067-Pos Board B83 INTERACTIONS OF ANTIBODIES WITH HIV 1 PROTEASE: TOWARDS IDENTIFICATION OF NEW SMALL MOLECULES FOR THERAPY. Suchetana Gupta , Sangeetha Balasubramanian, Sanjib Senapati 2068-Pos Board B84 INTERACTION OF CLITORIA TERNATEA L. FLOWER EXTRACT WITH ALPHA- AMYLASE BY PHOTON STREAMING TIME-RESOLVED FLUORESCENCE.  Graham Hungerford , Rachael Divers, M. Adilia Lemos, Boon-Seang Chu Eda Koculi 2058-Pos

2040-Pos Board B56 IDENTIFYING NOVEL INTERACTING PARTNERS FOR THE UNC-45 CHAPER- ONE IN DROSOPHILA MELANOGASTER . Daniel Smith 2041-Pos Board B57 MECHANISTIC BASIS FOR CLIENT RECOGNITION AND amYLOID INHIBI- TION OF NMNAT. Shengnan Zhang , Xiaojuan Ma, Dan Li, Cong Liu 2042-Pos Board B58 MAPPING INTERACTIONS BETWEEN THE CHAPERONE DOMAIN OF UNC- 45B AND MYOSIN. Michael Villarreal, Eleno Garza, Andres Oberhauser 2043-Pos Board B59 CRYO-EM ANALYSIS OF THE AAA+ QUALITY CONTROL PROTEASE CLPXP. Mia Shin 2044-Pos Board B60 TEASING APART THE ROLE OF THE RIBOSOME AND MOLECULAR CHAPER- ONES IN CELLULAR PROTEIN FOLDING. Rayna M. Addabbo , Matthew D. Dalphin, Yue Liu, Miranda F. Mecha, Silvia Cavagnero 2045-Pos Board B61 STRUCTURES AND DYNAMICS OF PROTEIN FOLDING ON THE RIBOSOME BY NMR SPECTROSCOPY. Anais M. Cassaignau , Christopher Waudby, Tomasz Wlodarski, Lisa Cabrita, John Christodoulou 2046-Pos Board B62 THERMODYNAMIC STABILITY OF POLAR AND NON-POLAR FIBRILS.  Farbod Mahmoudinobar , Zhaoqian Su, Cristiano L. Dias 2047-Pos Board B63 EFFECT OF GENE POLYMORPHISMS ON THE STRUCTURAL DYNAMICS OF PRION PROTEINS: A COMPARATIVE STUDY. Noah Yoshida , India Claflin, Oscar Coello, Patricia Soto 2048-Pos Board B64 MEMBRANE BINDING OF PARKINSON’S PROTEIN ALPHA-SYNUCLEIN: EFFECT OF PHOSPHORYLATION AT POSITIONS 87 AND 129 BY THE S TO D MUTATION APPROACH. Pravin Kumar, Nathalie Schilderink, Mireille M.A.E. Claessens, Vinod Subramaniam, Martina Huber 2049-Pos Board B65 International Travel Awardee PH-INDUCED FRUSTRATION IN THE FREE ENERGY LANDSCAPE DICTATE MISFOLDING OF THE PRION PROTEIN. Roumita Moulick , Rama Reddy Goluguri, Jayant B. Udgaonkar 2050-Pos Board B66 THE PHYSICAL FACTORS GOVERNING TENSILE FORCE GENERATION BY CO-TRANSLATIONAL PROTEIN FOLDING. Sarah E. Leininger , Edward P. O’Brien 2051-Pos Board B67 PROBING THE EFFECT OF THE RIBOSOME ON THE PROTEIN FOLDING PATHWAY USING SINGLE-MOLECULE CHEMO-MECHANICAL FOLD- ING. Emily Guinn , Susan Marqusee Protein-Small Molecule Interactions III (Boards B68–B90) 2052-Pos Board B68 CHARACTERIZING THE DIRECT INFLUENCE OF A SMALL MOLECULE ON A RAS-RELATED PROTEIN INTERACTION. Djamali Muhoza, Alix Montoya- Beltran, Paul D. Adams 2053-Pos Board B69 A COMBRETASTATIN ANALOGUE C12 BINDS TO COLCHICINE SITE IN TU- BULIN, INHIBITS SPINDLE MICROTUBULE DYNAMICS, ACTIVATES MITOTIC CHECKPOINT AND INDUCES APOPTOSIS IN CANCER CELLS. Anuradha Kumari , Shalini Srivastava, Shweta Shyam Prassanawar, Shailendra Sisodiya, Sankar K. Guchhait, Dulal Panda

T U

E S

D A Y

124