Biophysical Society 63rd Annual Meeting | Program Guide

2368-Pos Board B40 INTEGRATION OF TEXT MINING AND BINARY QSAR MODELS FOR NOVEL ANTI-HYPERTENSIVE ANTAGONIST SCAFFOLDS. Serdar Durdagi , Ismail Erol, Berna Dogan, Taha Berkay Sen 2369-Pos Board B41 THE TWO FACES OF BITTER SUGARS: INSIGHTS FROMMULTISCALE SIMU- LATIONS. Fabrizio Fierro, Alejandro Giorgetti, Paolo Carloni, Wolfgang Meyerhof, Mercedes Alfonso Prieto 2370-Pos Board B42 STRUCTURAL BASES FOR CHEMICAL AND MECHANICAL GATING IN THE PIEZO1 CHANNEL. Wesley M. Botello-Smith, Han Zhang, Alper D. Ozkan, Wenjuan Jiang, Christine N. Pham, Yun Luo, Jerome J. Lacroix 2371-Pos Board B43 MOLECULAR INSIGHT INTO THE AGONIST PROPERTIES OF THE MULTI- MODAL ANTIDEPRESSANT VORTIOXETINE IN HUMAN 5-HT3A RECEP- TORS. Lucy Kate Ladefoged , Lachlan Munro, Anders S. Kristensen, Birgit Schiøtt 2372-Pos Board B44 ENERGETICS OF NUCLEOTIDES TRANSLOCATION THROUGH HIV-1 CA HEXAMER. Chaoyi Xu , Robert A. Dick, Marc C. Johnson, Volker M. Vogt, Juan R. Perilla 2373-Pos Board B45 STRUCTURE DYNAMICS GUIDES THE ENHANCEMENT OF LIGAND AFFIN- ITY FOR MDMX. Zhengding Su , Yongqi Huang, Xiyao Cheng 2374-Pos Board B46 CHARACTERIZING THE DIRECT INFLUENCE OF A SMALL MOLECULE ON A RAS-RELATED PROTEIN INTERACTION. Djamali Muhoza, Alix Montoya- Beltrand, Emilio Duverna, Paul D. Adams 2375-Pos Board B47 INHIBITION OF ZINC-MEDIATED AMYLOID BETA AGGREGATION AND CYTOTOXICITY BY ALPHA HELIX MIMETICS. Maria C. Vogel , Sunil Kumar, Debabrata Maity, Mazin M. Magzoub, Andrew D. Hamilton 2376-Pos Board B48 MODIFYING ZINC FINGERS: TARGETING THE INFLAMMATORY ZINC FIN- GER PROTEIN, TRISTETRAPROLIN, WITH EXOGENOUS GOLD COMPLEXES AND DETERMINING A ROLE FOR H 2 S IN MODIFYING TRISETRAPOLIN ENDOGENOUSLY. Kiwon Ok , Wenjing Li, Geoffrey D. Shimberg, Sharon Batelu, Mike Lange, Ivana Ivanovic-Burmazovic, Dr. Timothy Stemmler, Maureen A. Kane, Milos R. Filipovic, Sarah L. Michel 2377-Pos Board B49 BREADTH OF HUMAN MONOCLONAL ANTIBODIES ISOLATED FROM RTS,S/AS01 VACCINEES BINDING TO PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN ANTIGENS. S. Moses Dennison , Milite Abraha, Richard H.C. Huntwork, Kan Li, Dustin L. Mauldin, S. Munir Alam, Georgia D. Tomaras 2378-Pos Board B50 SYSTEMATIC BIOPHYSICAL INSIGHTS INTO THE INTERACTION OF ANTI MERS-COV DRUG RIBAVIRIN WITH MAJOR TRANSPORT PROTEIN IN HU- MAN SERUM: IN-VITRO STUDIES AND IMPLICATIONS IN DIABETES AND UREMIA. Fahad Almutairi , Mohammad Rehan Ajmal 2379-Pos Board B51 PERTURBING LIPOPOLYSACCHARIDE BIOSYNTHESIS THROUGH INHIBI- TION OF HEPTOSYLTRANSFERASE I.  Jozafina Milicaj 2380-Pos Board B52 TRAVEL AWARDEE CONTROL OF PROTEIN SELF-ASSEMBLY WITH WATER-SOLUBLE PORPHY- RINS. Tyler J. Brittain , Samuel D. Fontaine, Coleman Swaim, Daniel R. Marzolf, Oleksandr Kokhan

2354-Pos Board B26 EXPLORING THE EFFECT OF PREORGANIZATION ON BINDING AFFINITY IN CYCLIZED PEPTIDOMIMETICS. Allison Terry , Vincent Voelz 2355-Pos Board B27 EXPRESSION AND PURIFICATION OF COMPLEMENT PROTEINS FOR PROTEIN INTERACTION STUDIES. Matthew Gehm , Veronica Singh, Julia Board B28 PH-DEPENDENT PROPERTIES OF IONIZABLE RESIDUES IN THE HYDRO- PHOBIC INTERIOR OF A PROTEIN. Ankita Sarkar , Adrian E. Roitberg 2357-Pos Board B29 THIOAMIDE EFFECTS ON PROTEIN STRUCTURE. Kristen E. Fiore , D. Miklos Szantai-Kis, E. James Petersson 2358-Pos Board B30 EXPLORING THE SPACE OF ANTIMICROBIAL PEPTIDES GUIDED BY A DEEP LEARNING MODEL. Manpriya Dua , Amarda Shehu 2359-Pos Board B31 SIMULATING THE FOLDING STATES OF LATTICE PROTEINS WITHIN AN OSCILLATORY ENVIRONMENT. Austin H. Cheng , Cory J. Kim, Amy Y. Wang, Xuanye Zhu, Qizhang Jia, Kateri H. DuBay 2360-Pos Board B32 STUDYING COMPLEX BIOMOLECULAR DYNAMICS BY SINGLE-MOLECULE THREE-COLOR FRET. Anders Barth , Claus A. M. Seidel, Don C. Lamb 2361-Pos Board B33 STRUCTURAL STUDIES OF THE F C REGION OF MURINE IMMUNOGLOBU- LIN G ANTIBODIES USING SINGLE MOLECULE FRET. Cathrine A. Southern , Jenna Henning, Kirsten Kochan 2362-Pos Board B34 BINDING FREE ENERGY ANALYSIS OF PROGRAMMED CELL DEATH PRO- TEIN PD1 TO ITS LIGAND PD-L1. Peter C. Pan, Alireza Tafazzol , Xianwei Zhang, Yong Duan 2363-Pos Board B35 DETERMINING NATIVE-STATE DYNAMICS OF MITONEET USING HYDRO- GEN EXCHANGE MASS SPECTROMETRY. Namita Khajanchi , Rebeca Mena, Mary Konkle, Sheila Jaswal Protein-Small Molecule Interactions (Boards B36 - B67) 2364-Pos Board B36 THE EFFECTS OF LIGAND STRUCTURE ON PROTEIN-MULTIMODAL LIGAND INTERACTIONS. Camille Bilodeau , Edmond Y. Lau, Steve Cramer, Shekhar Garde 2365-Pos Board B37 PEPTIDE ASSISTED SUPRAMOLECULAR POLYMERIZATION OF THE AN- IONIC PORPHYRIN MESO-TETRA(4-SULFONATOPHENYL)PORPHINE. Eric Kohn , David Shirly, Christopher H. Fry, Gregory A. Caputo 2366-Pos Board B38 OPTIMIZATION OF THE SITE-IDENTIFICATION BY LIGAND COMPETITIVE SATURATION (SILCS) AS AN ACCURATE AND RELIABLE TECHNIQUE IN LEAD OPTIMIZATION. Vincent D. Ustach , Sirish Kauhik Lakkaraju, Sun- hwan Jo, Wenbo Yu, Fang-Yu Lin, Wenjuan Jiang, Alexander D. MacKerell 2367-Pos Board B39 THE WEAK ENZYMATIC ACTIVITY OF TRUNCATED LECITHIN RETINOL ACYLTRANSFERASE (LRAT) MUTANTS CANNOT BE EXPLAINED BY THEIR AFFINITY FOR ALL-TRANS RETINOL. Sarah Roy , Ana Coutinho, Line Cantin, Marie-Eve Gauthier, Manuel Prieto, Stephane M. Gagne, Christian Salesse R. Koeppe 2356-Pos

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