Biophysical Society 63rd Annual Meeting | Program Guide

2394-Pos Board B66 NUCLEAR MAGNETIC RESONANCE AT THE INTERFACE: IDENTIFYING PREFERRED BINDING REGIONS IN MULTIMODAL CATION EXCHANGE CHROMATOGRAPHY USING FUNCTIONALIZED NANOPARTICLES. Ronak B. Gudhka , Camille L. Bilodeau, Scott A. McCallum, Mark A. Mccoy, David J. Roush, Steven M. Cramer 2395-Pos Board B67 HOW DOES GLYCOSYLATION AFFECT DRUG BINDING ON INFLUENZA? THE ROLES OF ELECTROSTATICS AND STERICS EXAMINED THROUGH BROWNIAN DYNAMICS SIMULATIONS. Christian Seitz , Lorenzo Casalino, Gary Huber, Robert Konecny, Yu-Ming Huang, Rommie Amaro, J. Andrew McCammon Protein Dynamics and Allostery II (Boards B68 - B102) 2396-Pos Board B68 MECHANISM OF HSP104 FUNCTION POTENTIATION STUDIED BY HY- DROGEN-DEUTERIUM EXCHANGE DETECTED BY MASS SPECTROMETRY (HX-MS). Xiang Ye , Jiabei Lin, Leland C. Mayne, James Shorter, S. Walter Board B69 BINDING INTERFACE OF GAPDH TO THE AU RICH ELEMENTS FROM TNF-ALPHA MRNA REVEALED BY HYDROGEN DEUTERIUM EXCHANGE COUPLED WITH MASS SPECTROMETRY. Daniel J. Deredge , Michael White, Anh Tran, Patrick Wintrode, Elsa Garcin 2398-Pos Board B70 EFFECT OF PLASMIN CLEAVAGE ON THE DYNAMICS OF THE PROTE- ASE DOMAIN OF THE UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA). Constanza Torres-Paris , Yueyi Chen, Elizabeth A. Komives 2399-Pos Board B71 KINETIC AND STRUCTURAL COMPARISON OF HINT ENZYMES: THE ROLE OF DISTANT DYNAMICS ON CATALYSIS. Alex Strom 2400-Pos Board B72 TRAVEL AWARDEE CHARACTERIZING HP1-DRIVEN CHROMATIN COMPACTION USING NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY. Bryce E. Ackermann , Galia T. Debelouchina 2401-Pos Board B73 DYNAMICS MEDIATE SUBSTRATE RECOGNITION AND REMOTE COM- MUNICATION IN A PEPTIDE-BOND FORMING NRPS CYCLIZATION DO- MAIN. Subrata H. Mishra, Aswani K. Kancherla , Santrupti Nerli, Nikolaos Sgourakis, Daniel Dowling, Dominique P. Frueh 2402-Pos Board B74 MOLECULAR RESPONSES OF MUTAGENESIS IN NONRIBOSOMAL PEP- TIDE SYNTHETASE CYCLIZATION DOMAINS. Kenneth Marincin , Aswani Kancherla, Subrata H. Mishra, Daniel Dowling, Dominique P. Frueh 2403-Pos Board B75 AN ALLOSTERIC SIGNALING GOVERNS THE CRISPR-CAS9 FUNCTION.  Giulia Palermo , Clarisse Gravina Ricci, Ivan Rivalta, Victor S. Batista, James A. McCammon 2404-Pos Board B76 POSITIVE AND NEGATIVE SUBSTRATE INTERFERENCE SUPPORTED BY COINCIDING ENZYME RESIDUES. Magnus Wolf-Watz , Per Rogne, Elisabet Sauer-Eriksson, Uwe Sauer, Christian Hedberg Englander 2397-Pos

2381-Pos Board B53 BIOPHYSICAL CHARACTERIZATION OF BINDING INTERACTIONS OF PPAR WITH THC.  Iulia Bodnariuc , Margaret Renaud-Young, Justin L. MacCallum 2382-Pos Board B54 IDENTIFICATION OF NOVEL CYCLIN A2 BINDING SITE AND NANOMOLAR INHIBITORS. Stephanie Kim , Michele Alves, Patrick Gygli, Jose Otero, Steffen Lindert 2383-Pos Board B55 EXPLORING THE TOXICITY OF SMALL MOLECULE METABOLITE 3-HY- DROXY-3-METHYLGLUTARYL-COENZYME A (HMG-COA) IN THE PATHO- GENIC BACTERIUM ENTEROCOCCUS FAECALIS. Gillian M. Barth 2384-Pos Board B56 MAPPING THE BINDING TRAJECTORY OF A SUICIDE INHIBITOR IN HUMAN INDOLEAMINE 2,3 DIOXYGENASE 1. Khoa N. Pham , Syun-Ru Yeh 2385-Pos Board B57 STRUCTURE-GUIDED DEVELOPMENT OF DUAL INHIBITORS OF EGFR AND JNK TO TREAT GBM AND NSCLC. Haikui Yang , Ying Jiang, Ruohong Yan, Tingting Zhang, Jiajie Zhang 2386-Pos Board B58 TRAVEL AWARDEE TIGHT BINDING OF NATURAL POLYPHENOLS TO THE INTRINSICALLY DISORDERED MAMMALIAN HIGH MOBILITY GROUP PROTEIN AT-HOOK 2. Linjia Su , Jeremy Chambers, Fenfei Leng 2387-Pos Board B59 IMPROVED MODELING OF HALOGENATED LIGAND-PROTEIN INTERAC- TIONS USING THE DRUDE POLARIZABLE FORCE FIELD AND ADDITIVE CHARMM36/CHARMM GENERAL FORCE FIELD (CGENFF). Fang-Yu Lin 2388-Pos Board B60 MOLECULAR RECOGNITION OF NAPHTHOQUINONE-CONTAINING COM- POUNDS AGAINST HUMAN DNA TOPOISOMERASE II ATPASE DOMAIN: A MOLECULAR MODELING STUDY. Panupong Mahalapbutr 2389-Pos Board B61 DEVELOPMENT OF SMALL MOLECULE INHIBITORS TARGETING CLOSTRID- IUM DIFFICILE BINARY TOXIN USING THE SITE-IDENTIFICATION BY LIGAND COMPETITIVE SATURATION (SILCS) METHOD. Wenbo Yu , Edvin Pozhars- kiy, Kristen Varney, David J. Weber, Alexander D. MacKerell 2390-Pos Board B62 DIFFUSION-INFLUENCED REVERSIBLE LIGAND BINDING TO TWO IN- EQUIVALENT SITES.  Irina V. Gopich , Attila Szabo 2391-Pos Board B63 EDEMA FACTOR OF BACILLUS ANTHRACIS INTERACTING WITH ITS INHIBI- TORS.  Irène Pitard , Catherine Simenel, Damien Monet, Christophe Thom- as, Peggy Suzanne, Arnaud Blondel, Jacques Bellalou, Patrick Dallemagne, Inaki Guijarro, Daniel Ladant, Pierre Goossens, Therese E. Malliavin 2392-Pos Board B64 STUDY ON THE MECHANISM OF ANTI C-MET ACTIVITY OF BOC-PROTECT- ED AMINO GROUPS OF BITHIAZOLOPHANES BY USING SILCS. Tatsuya Takimoto , Ozge Yoluk, Sunhwan Jo, Alexander D. MacKerell, Jr., Hideaki Sasaki 2393-Pos Board B65 TRAVEL AWARDEE UNVEILING THE ROLE OF SURFACTANTS ON AMYLOID-LIKE PROTEIN SELF- ASSEMBLING. Gustavo Scanavachi , Yanis Ricardo Espinosa, Juan Ruso, Rosangela Itri

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