Biophysical Society 63rd Annual Meeting | Program Guide

132-Plat 11:00 am AN INNER ACTIVATION GATE CONTROLS TMEM16F PHOSPHOLIPIDS SCRAMBLING.  Trieu Le , ZhiGuang Jia, Yang Zhang, Son C. Le, Jianhan Chen, Huanghe Yang 133-Plat 11:15 am PREDICTION OF THE CLOSED CONFORMATION AND INSIGHTS INTO THE MECHANISM OF THE MEMBRANE ENZYME LPXR.  GrahamM. Saunders , Hannah E. Bruce Macdonald, Jonathan W. Essex, Syma Khalid 134-Plat 11:30 am STUDYING CONFORMATION OF THE VOLTAGE-SENSOR DOMAIN (VSD) OF THE HUMAN KCNQ1 POTASSIUM ION CHANNEL IN PROTEOLIPOSOMES USING EPR SPECTROSCOPY.  Indra D. Sahu , Gunjan Dixit, Warren Reyn- olds, Ben Harding, Colleen Jaycox, Fathima Dilhani Mohammed Faleel, Robert M. McCarrick, Charles R. Sanders, Gary A. Lorigan 135-Plat 11:45 am CRYO-EM STRUCTURES REVEAL BILAYER REMODELING DURING CA 2+ AC- TIVATION OF A TMEM16 SCRAMBLASE. Maria Falzone , Jan Rheinberger, Byoung-Cheol Lee, Thasin Peyear, Linda Sasset, Ashleigh Raczkowski, Edward Eng, Annarita Di Lorenzo, Olaf Anderson, Crina Nimigean, Alessio Accardi 136-Plat 12:00 pm UNCOVERING EUKARYOTIC GLYCOSYLATION MECHANISM BY CRYO-EM.  Lin Bai , Huilin Li 137-Plat 12:15 pm FOLDING MECHANISM OF Β-HELICAL PASSENGER DOMAINS FROM A BACTERIAL AUTOTRANSPORTER.  Anthony Hazel, Yui Tik Pang , James C. 12:30 pm MONITORING ROTATION DYNAMICS OF MEMBRANE PROTEIN IN LIVE CELLS.  Youngchan Park , Sangwon Shin, Hyeonggyu Jin, Jiseong Park, Yeonki Hong, Hyunjoon Song, Daeha Seo Platform Intrinsically Disordered Proteins (IDP) and Aggregates I 10:45 am - 12:45 pm, Room 307/308 Co-Chairs Francesco Aprile, University of Cambridge, United Kingdom Cecily Campbell-Bezat, D.E. Shaw Research 139-Plat 10:45 am TRAVEL AWARDEE PROXIMITY RULERS IN amYLOIDS AND LIQUID DROPLETS OF INTRINSI- CALLY DISORDERED PROTEINS.  Anupa Majumdar , Debapriya Das, Priyanka Dogra, Shiny Maity, Samrat Mukhopadhyay 140-Plat 11:00 am ATOMIC LEVEL CHARACTERIZATION OF AN ENSEMBLE OF amYLOID BETA OLIGOMERS.  Cecily K. Campbell-Bezat , Albert C. Pan, Daniel Jacobson, Shivam Verma, David E. Shaw 141-Plat 11:15 am ORDERED AND DISORDERED SEGMENTS OF amYLOID BETA DRIVE SEQUENTIAL STEPS OF THE TOXIC PATHWAY.  Barun K. Maity, Anand Kant Das, Simli Dey, Ullhas Kaarthi Moorthi, amandeep Kaur, Dayana Suren- dran, Rucha Pandit, Mamata Kallianpur, Bappaditya Chandra, Murlid- haran Chandrakesan, Senthil Arumugam, Sudipta Maiti 142-Plat 11:30 am TRAVEL AWARDEE UNDERSTANDING THE MOLECULAR PARAMETERS DETERMINING THE PATHOLOGICAL PROPERTIES OF amYLOID FIBRILS.  Harish Kumar , Jayant B. Udgaonkar 11:45 am Flash talks Gumbart 138-Plat

122-Symp 12:15 pm AFTER THE STRUCTURE COMES THE DYNAMICS: MOLECULAR MODELING OF GLUTAMATE RECEPTORS REVEALS LONG-RANGE ALLOSTERIC COU- PLING BETWEEN LIGAND BINDING SITE AND CHANNEL GATE.  Maria G. Kurnikova Platform Optical Microscopy and Superresolution Imaging I 10:45 am - 12:45 pm, Ballroom III Co-Chairs DNA INTERCALATORS TILT, WOBBLE AND TWIRL; ELUCIDATING THE STRUCTURE OF S-DNA.  Adam Backer , Andreas S. Biebricher, Graeme A. King, Gijs J. L. Wuite, Iddo Heller, Erwin J. G. Peterman 124-Plat 11:00 am NUCLEAR DEFORMATION WITH COMBINED AFM AND 3D MULTI-COLOR LIVE-CELL LINE BESSEL SHEET IMAGING.  Chad Hobson , Evan F. Nelsen, Joe Hsiao, Andrew Stephens, E. Timothy O’Brien, Michael R. Falvo, Rich- ard Superfine 125-Plat 11:15 am MULTI-MODAL FLUORESCENCE CHARACTERIZATION OF CELL CYCLE PRO- GRESSION AND CYTOKINESIS.  Rachel Cinco , Per Niklas Hedde, Leonel Malacrida, Michelle A. Digman, Enrico Gratton 126-Plat 11:30 am ELIMINATING BACKGROUND NOISE FOR STED SUPER-RESOLUTION MICROSCOPY USING POLARIZATION SWITCHING.  Jong-Chan Lee , Ye Ma, Kyu Young Han, Taekjip Ha 127-Plat 11:45 am THE NUCLUEAR PORE COMPLEX AS INTRINSIC REPORTER FOR ISOTROPIC EXPANSION MICROSCOPY.  Paolo Bianchini , Luca Pesce, Marco Cozzolino, Luca Lanzano’, Alberto Diaspro 128-Plat 12:00 pm MULTICOLOR SINGLE-PARTICLE RECONSTRUCTION OF PROTEIN COM- PLEXES.  Christian Sieben , Niccoló Banterle, Kyle M. Douglass, Pierre Gönczy, Suliana Manley 129-Plat 12:15 pm INTRACELLULAR ANALYSIS OF INDIVIDUAL CELLS AND ORGANELLES FOR BOTH OXYGEN CONCENTRATION/CONSUMPTION AND NADH FREE/ BOUND REDOX STATE USING FLUORESCENCE LIFETIME IMAGING.  Rozhin Penjweini , Alessio Andreoni, Anahit Gevorgyan, Dan L. Sackett, Jay R. Knutson 130-Plat 12:30 pm 3D IMAGING OF SINGLE CELLS IN BACTERIAL BIOFILMS USING LATTICE LIGHT-SHEET MICROSCOPY. Mingxing Zhang, Ji Zhang, Jie Wang, Alecia M. Achimovich, Arslan A. Aziz, Jacqueline Corbitt, Scott T. Acton, Andreas Gahlmann Platform Membrane Proteins I 10:45 am - 12:45 pm, Ballroom IV Co-Chairs Ana-Nicoleta Bondar, Freie University,Berlin Anne Hinderliter, University of Minnesota, Duluth 131-Plat 10:45 am INVESTIGATING HOWMEMBRANE ELASTICITY IMPACTS MEMBRANE PROTEIN FOLDING. Miranda L. Jacobs , Neha P. Kamat Andreas Gahlmann, University of Virginia Rachel Cinco, University of California, Irvine 123-Plat 10:45 am

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