Biophysical Society 63rd Annual Meeting | Program Guide

Platform Excitation-Contraction Coupling/Cardiac and Skeletal Muscle Electrophysiology I 10:45 am - 12:45 pm, Room 314/315 Co-Chairs OLIGOMERIZATION OF MICROPEPTIDES THAT REGULATE SERCA.  Deo R. Singh , Ellen Cho, Michael Dalton, Marsha Pribadi, Catherine A. Makarewich, Eric N. Olson, Seth L. Robia 155-Plat 11:00 am THE EFFECT OF THE SK CHANNEL INHIBITOR ICAGEN IN INTACT ATRIA AND ATRIAL CARDIOMYOCYTES.  Sara Dobi , Godfrey L. Smith 156-Plat 11:15 am THE MECHANISM OF CARDIOVASCULAR PATHOPHYSIOLOGY IN CANTU SYNDROME AND RESPONSE TO GLIBENCLAMIDE IN NOVEL KATP CHAN- NEL MUTANT MOUSE MODELS.  Conor McClenaghan , Yan Huang, Car- men Halabi, Theresa Harter, Robert P. Mecham, Maria S. Remedi, Colin G. Nichols 157-Plat 11:30 am OPTOGENETIC CURRENTS IN MYOFIBROBLASTS PRODUCE ACUTE CHANGES IN ELECTROPHYSIOLOGY OF COCULTURED CARDIOMYOCYTES.  Geran Kostecki , Yu Shi, Dan Reich, Emilia Entcheva, Leslie Tung 158-Plat 11:45 am BLOOD FLOW CONTROL BY ATP-SENSITIVE POTASSIUM CHANNEL IN HEART.  Guiling Zhao , Humberto C. Joca, W. Jonathan Lederer 159-Plat 12:00 pm TRAVEL AWARDEE VEGF-INDUCED VASCULAR LEAK PROMOTES ATRIAL FIBRILLATION BY DISRUPTING INTERCALATED DISC NANODOMAINS.  Louisa Mezache , Heather Struckman, amara Greer-Short, Anna Phillips, Alex Martinson, Justin Thomas, Przemyslaw Radwanski, Thomas J. Hund, Rengasayee Veeraraghavan 160-Plat 12:15 pm RECOVERY FROM INTRACELLULAR ACIDOSIS TRIGGERS LOSS OF FORCE IN HYPOKALEMIC PERIODIC PARALYSIS. Wentao Mi, Fenfen Wu, Marbella Quinonez, Marino DiFranco, Steve C. Cannon 161-Plat 12:30 pm S-NITROSYLATION OF CX43 HEMICHANNELS PROMOTES CARDIAC AR- RHYTHMIAS IN A DUCHENE MUSCULAR DYSTROPHY MOUSE MODEL.  Mauricio A. Lillo , Eric Himelman, Lai-Hua Xie, Diego Fraidenraich, Jorge E. Contreras Platform Stephen Cannon, University of California, Los Angeles Guiling Zhao, University of Maryland School of Medicine 154-Plat 10:45 am Co-Chairs Kaipei Qiu, East China University of Science and Technology Rachael Knoblauch, University of Maryland Baltimore County 162-Plat 10:45 am POROUS ZERO-MODE WAVEGUIDES FOR PICOGRAM-LEVEL DNA SE- QUENCING.  Vivek S. Jadhav, David P. Hoogerheide, Jonas Korlach, Meni Wanunu 163-Plat 11:00 am NURTURING NATURE FOR NANOTECHNOLOGY. Michael Zwolak 164-Plat 11:15 am MEASURING THE CONFORMATION OF SINGLE STRANDED DNA USING A DNA ORIGAMI NANO-STRUCTURE.  Yuval Garini , Efrat Roth, Arkady Bitler, Olga Girshevitz Micro- and Nanotechnology 10:45 am - 12:45 pm, Room 316/317

143-Plat 12:00 pm REDOX KINETICS OF THE amYLOID-BETA-COPPER COMPLEX AND ITS BIO- LOGICAL IMPLICATIONS.  Paul Girvan , Xiangyu Teng, Nicholas J. Brooks, Geoffrey S. Baldwin, Liming Ying 144-Plat 12:15 pm MULTIPLE-PHOSPHORYLATION TO IDR IN THE CHROMATIN REMODELER FACT SHOWS AN ‘ ULTRASENSITIVE ’ RESPONSE IN ITS NUCLEOSOME BINDING.  Shin-ichi Tate 145-Plat 12:30 pm TARGETING THE FORMATION OF amYLOID OLIGOMERS USING RATIO- NALLY DESIGNED ANTIBODIES.  Francesco A. Aprile , Pietro Sormanni, Michele Perni, Paolo Arosio, Sara Linse, Tuomas P. Knowles, Christopher M. Dobson, Michele Vendruscolo Platform Cardiac Muscle Mechanics, Structure, and Regulation I 10:45 am - 12:45 pm, Room 309/310 Co-Chairs Jesus Ovejero, King’s College London, United Kingdom Vitold Galkin, Eastern Virginia Medical School 146-Plat 10:45 am ADVANCED MORPHO-FUNCTIONAL ANALYSIS ON VENTRICULAR AND ATRIAL TISSUE REVEALS CROSS-BRIDGE KINETICS ALTERATIONS AND SARCOMERE ENERGETIC IMPAIRMENT IN HCM PATIENTS.  Giulia Vitale , Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J Pioner, Ceci- lia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi 147-Plat 11:00 am TROPOMYOSIN CABLE FORMATION AND ITS INFLUENCE ON THE STRUC- TURAL DYNAMICS OF TROPOMYOSIN.  Farooq A. Kiani, William Lehman, Stefan Fischer, Michael J. Rynkiewicz 148-Plat 11:15 am TRAVEL AWARDEE PROTEIN KINASE C-MEDIATED CARDIAC TROPONIN I S43/45 PHOS- PHORYLATION CAUSES CONTRACTILE DYSFUNCTION IN HUMAN HEART FAILURE AND IN RODENTS.  Vani S. Ravichandran , Tabea M. Schatz, Margaret V. Westfall 149-Plat 11:30 am BETA-MYOSIN HEAVY CHAIN POST-TRANSLATIONAL MODIFICATIONS IN FAILING AND NON-FAILING HUMAN HEARTS. Michelle S. Parvatiyar , Rakesh K. Singh, Elizabeth A. Brundage, Bryan A. Whitson, Paul M.L. Jans- sen, Brandon J. Biesiadecki, J. Renato Pinto 150-Plat 11:45 am A FAMILIAL DILATED CARDIOMYOPATHY MUTATION DECREASES MYOSIN GENERATED TENSION AT THE MOLECULAR LEVEL AND ALTERS MECHA- NOSENSING AT THE CELLULAR LEVEL.  Sarah R. Clippinger , Paige E. Cloonan, Lina Greenberg, William Stump, Michael J. Greenberg 151-Plat 12:00 pm MYOCARDIAL SLICES - A NOVEL PLATFORM FOR IN VITRO BIOMECHANI- CAL STUDIES.  Fotios Pitoulis , Samuel A. Watson, Eef Dries, Ifigeneia Bardi, Raquel Nunez-Toldra, Filippo Perbellini, Cesare M. Terracciano 152-Plat 12:15 pm LEVERAGING NATURAL CARDIOMYOCYTE VARIABILITY TO DISCOVER NOVEL GENES IN CANONICAL SIGNALING PATHWAYS.  Jeffery A. Clark , Jonathan D. Weiss, Stuart G. Campbell 153-Plat 12:30 pm RECRUITMENT FROMMYOSIN OFF STATE STEEPENS ESPVR IN FINITE ELEMENT MODEL OF LEFT VENTRICLE.  Charles K. Mann , Zhanqui Liu, Xiaoyan Zhang, Kenneth Campbell, Jonathan Wenk

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