Biophysical Society 63rd Annual Meeting | Program Guide

770-Plat TRAVEL AWARDEE MOLECULAR LINK BETWEEN MCU AND MRS2P CHANNELS FOR MITO- CHONDRIAL ION HOMEOSTASIS AND ENERGY METABOLISM.  Shanmughapriya Santhanam , Xueqian Zhang, Jianliang Song, Joseph Y. Cheung, Peter Basile Stathopulos, Muniswamy Madesh 771-Plat 9:45 am MITOCHONDRIAL MEGACHANNEL RESIDES IN MONOMERIC ATP SYNTHASE.  Nelli Mnatsakanyan , Han-A Park, Wu Jing, Marc C. Llaguno, Besnik Murtishi, Maria Latta, Ellie Davis, Paige Miranda, Youshan Yang, Fred Sigworth, Elizabeth A. Jonas 772-Plat 10:00 am MITOCHONDRIAL CREATINE KINASE ATTENUATES ROS EMISSION AND IMPROVES MYOCYTE SURVIVAL AFTER ROS IN THE FAILING HEART.  Gizem Keceli , Joevin Sourdon, Ashish Gupta, Carlo G. Tocchetti, Bongsoo Park, Jacopo Agrimi, Michelle Leppo, Genaro A. Ramirez-Correa, Shyam S. Biswal, Nazareno Paolocci, Robert G. Weiss Platform Microtubules, Structure, Dynamics 9:30 am SEVERING ENZYMES amPLIFY MICROTUBULE ARRAYS THROUGH LATTICE GTP-TUBULIN INCORPORATION.  Annapurna Vemu , Ewa Szczesna, Elena A. Zehr, Jeffrey O. Spector, Nikolaus Grigorieff, Alexandra M. Deacones- cu, Antonina Roll-Mecak 774-Plat 8:30 am DIRECT OBSERVATION OF INDIVIDUAL TUBULIN DIMERS BINDING TO GROWING MICROTUBULES.  Keith J. Mickolajczyk , Elisabeth Geyer, Tae Kim, Luke Rice, William O. Hancock 775-Plat 8:45 am COMPUTATIONAL MODELING AND CRYO ELECTRON TOMOGRAPHY RE- VEAL A NEWMECHANISM FOR MICROTUBULE ASSEMBLY AND DYNAM- ICS.  Nikita B. Gudimchuk , Evgeni V. Ulyanov, Eileen O’Toole, Dmitrii S. Vinogradov, Fazly I. Ataullakhanov, J. Richard McIntosh 776-Plat 9:00 am DYNAMIC INSTABILITY AND TREADMILLING COEXIST FOR IN VITRO MICROTUBULES.  Goker Arpag , Marija Zanic 777-Plat 9:15 am ACTIVE FLUCTUATIONS OF MICROTUBULE NETWORKS FACILITATE FASTER MOTILITY OF DYNEIN.  Yasin Ezber 778-Plat 9:30 am OXIDATIVE STRESS RESTRUCTURES THE CELLULAR MICROTUBULE CYTO- SKELETON VIA REPAIR-MEDIATED RESCUE EVENTS.  Rebecca R. Goldblum , Kyle White, Mark McClellan, Joseph M. Metzger, Melissa K. Gardner 779-Plat 9:45 am TAU’S PROLINE RICH REGION DOMINATES TUBULIN BINDING.  Kristen McKibben , Elizabeth Rhoades 780-Plat 10:00 am MECHANISMS OF BIDIRECTIONAL TRANSPORT OF MISALIGNED CHRO- MOSOMES IN MITOSIS.  Saad Ansari , Zachary Gergely, Christopher Edelmaier, Nicolas Santander, Patrick Flynn, Adam Lamson, Matthew A. Glaser, J. Richard McIntosh, Meredith D. Betterton and Associated Proteins 8:15 am - 10:15 am, Room 309/310 Co-Chairs Annapurna Vemu, NIH William Hancock, Pennsylvania State University 773-Plat 8:15 am

759-Plat TRAVEL AWARDEE ENDOTHELIAL CELL REGULATION OF EXCITATION-CONTRACTION COU- PLING IN INDUCED PLURIPOTENT STEM CELL DERIVED MYOCARDIUM.  Oisín King , Fatemeh Kermani, Brian Wang, Warrapong Kit-Anan, Jerome Fourre, Anna M. Randi, Cesare M. Terracciano 760-Plat 9:00 am BIOCHEMICAL AND EPIGENETIC MODIFICATIONS OCCUR IN MUSCLES OF PATIENTS WITH SELENOPROTEIN N RELATED CONGENITAL MYOPA- THY.  Christoph Bachmann, Nicol Voermans, Heinz Jungbluth, Francesco Muntoni, Francesco Zorzato, Susan Treves 761-Plat 9:15 am STRUCTURAL INSIGHTS INTO RECOGNITION OF RYANODINE RECEPTORS BY PKA.  Omid Haji-Ghassemi, Zhiguang Yuchi, Filip Van Petegem 762-Plat 9:30 am ACUTE GENETIC ABLATION OF SODIUM-CALCIUM EXCHANGE: ADAPTA- TIONS OF EXCITATION-CONTRACTION COUPLING AND CALCIUM REGULA- TION.  Sabine Lotteau , Rui Zhang, Christina Grabar, Stephan Aynaszyan, Xin Yue, Yushun Zhang, Kenneth D. Philipson, Michela Ottolia, Joshua I. Goldhaber 763-Plat 9:45 am MUSCLES FROM CALSEQUESTRIN-1 KNOCKOUT MICE CONTAIN PRE- ASSEMBLED CALCIUM ENTRY UNITS THAT PROVIDE CONSTITUTIVELY ACTIVE STORE-OPERATED CALCIUM ENTRY.  Antonio Michelucci , Simona Boncompagni, Laura Pietrangelo, Robert Dirksen, Feliciano Protasi 764-Plat 10:00 am NOVEL MORPHOLOGICAL AND FUNCTIONAL INSIGHTS IN PYTHON CAR- DIAC BIOLOGY.  Claudia Crocini , Kathleen C. Woulfe, Leslie A. Leinwand Platform 8:45 am Co-Chairs William Cramer, Purdue University Santhanam Shanmughapriya, Pennsylvania State University 765-Plat 8:15 am STRUCTURE-BASED CHANGE IN THE RATE-LIMITING STEP OF PHOTOSYN- THETIC ELECTRON TRANSPORT. William A. Cramer , J. Ness, S. Saif Hasan, Katherine Ehringer, Sejuti Naurin, Valentyn Stadnytskyi, Iskander M. Ibrahim, Sujith Puthiyaveetil 766-Plat 8:30 am CHEMOMECHANICAL COUPLING OF MITOCHONDRIAL COMPLEX I.  Chitrak Gupta , Umesh Khaniya, Chun Kit Chan, Marilyn Gunner, Chris- tophe Chipot, Francois Dehez, Abhishek Singharoy 767-Plat 8:45 am A NEW SYNTHETIC FRET SENSOR TO ANALYZE ALLOSTERIC amPK ACTIVA- TION AND CELLULAR ENERGY STATE.  Uwe Schlattner , Martin Pelosse, Imre Berger 768-Plat 9:00 am HOW THE NANOARCHITECTURE OF CARDIAC MUSCLE MITOCHONDRIA AFFECTS FUNCTION: LESSONS FROM COMPUTER SIMULATIONS.  Carmen A. Mannella , Zheng Liu, Chyongere Hsieh, Nasrin Afzal, Raquel A. Adams, M. Saleet Jafri, W. Jonathan Lederer 769-Plat 9:15 am HUMAN VDAC3 FORMS VDAC1-TYPE ANIONIC CHANNELS THAT ARE HIGH-CONDUCTING, PERMEABLE TO METABOLITES, AND REGULATED BY CYTOSOLIC PROTEINS. Maria Queralt-Martin , Lucie A. Bergdoll, Jeff Abramson, Daniel Jacobs, Oscar Teijido Hermida, David P. Hoogerheide, Sergey M. Bezrukov, Tatiana K. Rostovtseva Energy Transducing Complexes and Mitochondria in Cell Life and Death 8:15 am - 10:15 am, Room 307/308

M O N D A Y

57