Biophysical Society 63rd Annual Meeting | Program Guide

Career Development Center Workshop Demystifying the Academic Job Search II: Preparing your Written Application Materials: CV, Cover Letter, and Research Statement 10:00 am - 11:00 am, Exhibit Hall A Over 90% of the cuts in a typical academic job search are made on the basis of your written application materials. Given the large number of candidates in a typical applicant pool, your documents must convey the most important information about you in the most clear and ef- ficient manner. Learn about how your materials should differ based on the type of institution and/or program, and how to create “glance- able” documents to speak most effectively on your behalf.

In addition to these naturally occurring paramagnetic species, spin labels can be incorporated into a number of biomolecules via SDSL (Site Directed Spin Labeling). Applications and techniques are: • Motional dynamics of proteins, peptides, and nucleotides via linse- hape analysis • Accessibility studies in membrane proteins or peptides via satura- tion measurements • Distance measurements (2-8 nm) via DEER (Double Electron-Elec- tron Resonance) to complement other structural methods such as X‑ray, NMR, CryoEM and FRET An introduction to the techniques and applications will be presented. Speakers Ralph Weber, Senior Application Scientist, Bruker Corporation Clemens Anklin, Vice President Applications, Bruker Corporation Symposium Phase Separations in the Cell 10:45 am - 12:45 pm, Ballroom I Chair Geeta Narlikar, University of California, San Francisco 797-Symp 10:45 am PHASE SEPARATION: PREDICTION AND ROLE IN BIOLOGICAL REGULA- TION.  Robert M. Vernon, Brian Tsang, Tae Hun Kim, Andrew Chong, Julie D. Forman-Kay 798-Symp 11:15 am A PROTEIN CONDENSATE DRIVES ACTIN-INDEPENDENT ENDOCYTOSIS.  Stephen Michnick , Louis-Philippe Bergeron-Sandoval, Rohit Pappu, Paul François, Adam G. Hendricks, Allen J. Ehrlicher, Hossein Khadivi Heris 799-Symp 11:45 am MAKING AND BREAKING THE SYMMETRY BETWEEN SEQUENCE-SPECIFIC CONFORMATIONAL AND PHASE BEHAVIORS OF DISORDERED PROTEINS.  Rohit V. Pappu 800-Symp 12:15 pm THE ROLE OF PHASE-SEPARATION IN HETEROCHROMATIN.  Geeta Narlikar , Serena Sanulli, John D. Gross, Patrick Griffin, Mike Trnka Symposium Regulation of Cardiomyocyte Beating 10:45 am - 12:45 pm, Ballroom II Chair Beth L. Pruitt, University of California, Santa Barbara 801-Symp 10:45 am MULTIMERIC PROTEIN COMPLEXES IN REGULATION OF CARDIOMYOCYTE CALCIUM CYCLING AND SURVIVAL.  Litsa Kranias 802-Symp 11:15 am SLOW AND FAST TIME SCALES IN CARDIOMYOCYTE BEATING.  Ohad Cohen , Samuel Safran 803-Symp 11:45 am WHY AND WHEN YOUR NEXT HEARTBEAT WILL OCCUR.  Edward G. Lakatta 804-Symp 12:15 pm INVITED SPEAKER: MECHANOBIOLOGY OF ENGINEERED HIPSC CARDIOMYOCYTES.  Beth L. Pruitt

M O N D A Y

Exhibits 10:00 am - 5:00 pm, Exhibit Hall Coffee Break 10:15 am - 11:00 am, Exhibit Hall

New Member Welcome Coffee 10:15 am - 11:15 am, Room 321/322/323

Calling all new BPS members! Come and mingle with BPS Staff, Soci- ety Council, and programmembers as you learn about the Society’s activities. Current members are welcome to come and meet with new members. Exhibitor Presentation Bruker Corporation 10:30 am - 12:00 pm, Room 301 USING NMR (NUCLEAR MAGNETIC RESONANCE) AND EPR (ELECTRON PARAMAGNETIC RESONANCE) IN BIOPHYSICS Magnetic resonance offers many insights into how biological systems function. The two techniques shed light on the identity of species, dy- namics, and structures of proteins, peptides, nucleotides, and lipids. The speakers will present an overview of these techniques and applications for people who may be new to the field and wish to incorporate them in their studies. NMR is a valuable tool for the study of structures and dynamic processes of proteins, peptides and nucleotides. NMR is also well suited to study the interaction of such molecules. Various NMR methods exist to study the interaction of proteins with small molecules in drug discovery, inter- actions of proteins with each other or with peptides and nucleotides. In drug discovery fragment based screening by NMR is a well-established technique. A brief presentation of these methods will be included. The investigation of interaction between larger molecules is facilitated by several NMR methods and by the use of isotopic labeling. Interactions such as protein oligomerization, protein-protein and proteinnucleotide interaction in solutions can be investigated. An overview of these tech- niques and applications will be included. In contrast to NMR, EPR detects unpaired electrons in free radicals and transition metal ions. One electron transfer reactions result in unpaired electrons. Examples of paramagnetic species encountered in biology are: • ROS (Reactive Oxygen Species), RNS (Reactive Nitrogen Species) • Amino acid radicals such as tyrosine and tryptophan radicals • Paramagnetic intermediates in photosynthesis • Metalloenzymes

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