Biophysical Society 63rd Annual Meeting | Program Guide

Symposium Future of Biophysics 10:45 am - 12:45 pm, Ballroom III

Platform Membrane Structure 10:45 am - 12:45 pm, Room 307/308

M O N D A Y

Co-Chairs Susan Marqusee, University of California, Berkeley Andrej Sali, University of California, San Francisco No Abstract 10:45 am

Co-Chairs Sarah Shelby, University of Michigan Ingela Parmryd, University of Gothenburg, Sweden 813-Plat 10:45 am

LIVE CELL IMAGING OF RNA DYNAMICS IN MAMMALIAN CELLS USING RIBOGLOW, A RIBOSWITCH-BASED FLUORESCENCE TAGGING PLATFORM.  Esther Braselmann No Abstract 11:15 am SCULPTING EMBRYOS VIA CONTROLLED FLUID-TO-SOLID TISSUE TRANSI- TIONS.  Otger Campas No Abstract 11:45 am OPTICAL DISSECTION OF CLASS C GPCR ASSEMBLY, ACTIVATION, AND SIGNALING MECHANISMS.  Joshua Levitz No Abstract 12:15 pm MESOSCALE ARCHITECTURE OF Β-CELLS UPON STIMULATION WITH GLU- COSE AND EX-4.  Kate L. White Platform Protein Dynamics and Allostery I 10:45 am - 12:45 pm, Ballroom IV Co-Chairs TARGETING CONFORMATIONAL ENTROPY TO MODULATE BINDING AF- FINITY.  José A. Caro , Shannen Cravens, Kathleen G. Valentine, A. Joshua Wand 806-Plat 11:00 am E. COLI ADENYLATE KINASE EXHIBITS INTER-DOMAIN COUPLING.  Joseph E. Rehfus , Vincent J. Hilser 807-Plat 11:15 am TRAVEL AWARDEE A THERMODYNAMIC VIEW OF DYNAMIC ALLOSTERY IN A PDZ DOMAIN PROTEIN.  amit Kumawat, Suman Chakrabarty 808-Plat 11:30 am STRUCTURAL FLUCTUATIONS ARE KEY TO ALLOSTERIC STIMULATION OF NDV HEMAGGLUTININ-NEURAMINIDASE.  Nalvi D. Duro , Sameer Varma 809-Plat 11:45 am SINGLE-MOLECULE FLUORESCENCE MEASUREMENTS OF TRANSIENT PROTEIN COMPLEXES DETERMINED VIA DIFFUSION-INDEPENDENT MI- CROFLUIDIC MIXING.  Johann Thurn , Bjorn Hellenkamp, Thorsten Hugel 810-Plat 12:00 pm STRUCTURAL DYNAMICS COUPLE SUBSTRATE-INDUCED ALLOSTERIC RESPONSES WITH DOMAIN COMMUNICATION IN NONRIBOSOMAL PEPTIDE SYNTHETASES.  Subrata H. Mishra, Aswani K. Kancherla, Kenneth Marincin, Santrupti Nerli, Nikolaos Sgourakis, Daniel Dowling, Dominique P. Frueh 811-Plat 12:15 pm MARKOV STATE MODEL OF INFLUENZA HEMAGGLUTININ REVEALS STRUCTURAL BASIS FOR GROUP 1 INFLUENZA INHIBITION BY ARBIDOL.  Sarah E. Kochanek , Rommie E. amaro 812-Plat 12:30 pm A GENERAL METHOD TO DESIGN ALLOSTERIC CONFORMATIONAL SWITCHES.  Ronald L. Koder , Peter J. Schnatz, Joseph Brisendine, Craig Liang, Bernard H. Everson, Cooper French Jose Caro, University of Pennsylvania Joseph Rehfus, Johns Hopkins University 805-Plat 10:45 am

LIPID BILAYER STRUCTURE REFINEMENT WITH SAXS/SANS BASED RE- STRAINED ENSEMBLE MOLECULAR DYNAMICS.  Yevhen K. Cherniavskyi , D. Peter Tieleman 814-Plat 11:00 am DISTRIBUTION OF MECHANICAL STRESS IN THE ESCHERICHIA COLI CELL ENVELOPE.  Sunny Hwang , Nicolo Paracini, Jerry M. Parks, Jeremy H. Lakey, James C. Gumbart 815-Plat 11:15 am MICRODOMAIN STRUCTURE AND MECHANICAL PROPERTIES OF LIPID MONOLAYERS MIMICKING RED BLOOD CELL MEMBRANES UNDER OXI- DATIVE STRESS.  Bob-Dan Lechner , Paul Smith, Peter C. Winlove, Chris D. Lorenz, Peter G. Petrov 816-Plat 11:30 am PHASE PARTITIONING OF PEPTIDE ANCHORS IN PLASMA MEMBRANE VESICLES PREDICTS THEIR RECRUITMENT TO B CELL RECEPTOR CLUSTERS IN LIVE CELLS.  Sarah A. Shelby , Ivan C. Serrano, Kandice R. Levental, Ilya Levental, Sarah L. Veatch 817-Plat 11:45 am MEMBRANE TOPOGRAPHY CREATES THE APPEARANCE OF ANOMALOUS DIFFUSION.  Ingela Parmryd , Jeremy Adler, Ida-Maria Sintorn, Robin Strand 818-Plat 12:00 pm INTERACTION OF LIPIDS WITH VOLTAGE-GATED ION CHANNEL PROTEINS. Nidhin Thomas, Kranthi Kiran Mandadapu, Ashutosh Agrawal 819-Plat 12:15 pm TRAVEL AWARDEE THE IMPORTANCE OF GLYCOLIPID CROSSLINKING IN ALTERING THE MEMBRANE CURVATURE.  Abir Kabbani , Krishnan Raghunathan, Anne Kenworthy, Wayne Lencer, Christopher V. Kelly 820-Plat 12:30 pm TRAVEL AWARDEE DYSLIPIDEMIA INDUCED ENDOTHELIAL STIFFENING IS ACCOMPANIED BY INCREASED MEMBRANE TENSION. Manuela A. Ayee , Irena Levitan Platform Computational Methods and Bioinformatics 10:45 am - 12:45 pm, Room 309/310 Co-Chairs Swagata Pahari, Clemson University Zhaleh Ghaemi, University of Illinois at Urbana–Champaign 821-Plat 10:45 am MEMBRANE PERMEABILITY FROM CONVENTIONAL MD SIMULATIONS: COUNTING TRANSITIONS VS. BAYESIAN ANALYSIS.  Andreas Krämer , Rich- ard M. Venable, Eric Z. Wang, Bernard R. Brooks, Richard W. Pastor 822-Plat 11:00 am COMPUTING LONG TIME DYNAMICS USING DYNAMICALLY CORRECTED KINETIC MONTE CARLO (DC-KMC).  Animesh Agarwal , Cesar A. Lopez, Nicolas W. Hengartner, Sandrasegaram Gnanakaran, Arthur F. Voter 823-Plat 11:15 am DYNAMIC COMBINATORIAL ANALYSIS OF LOCAL CONFIGURATIONS IN MOLECULAR DYNAMICS SIMULATION: FREQUENT ITEMSET MINING AND HIERARCHICAL HIDDEN MARKOV MODEL.  Ka Chun Ho , Donald Hamel- berg

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