Biophysical Society 63rd Annual Meeting | Program Guide

824-Plat 11:30 am SURFACE-FREE PROTOCOL FOR COMPUTING PKA’S (DELPHIPKA): APPLI- CATIONS TO PROTEIN-PROTEIN INTERACTIONS.  Swagata Pahari , Lexuan Sun, Emil Alexov 825-Plat 11:45 am TRAVEL AWARDEE STRUCTURAL TOPOLOGY OF GLYCOPROTEIN SURFACE NETWORKS US- ING HIGH THROUGHPUT ATOMISTIC MODELING AND GRAPH THEORY.  Srirupa Chakraborty , Zachary Berndsen, Cesar Lopez, AndrewWard, Bette Korber, Nicolas Hengartner, S. Gnanakaran 826-Plat 12:00 pm TRAVEL AWARDEE A COMPUTATIONAL HUMAN WHOLE-CELL MODEL REVEALS THE EFFECTS OF SPATIAL ORGANIZATION ON RNA SPLICING.  Zhaleh Ghaemi , Zaida Luthey-Schulten 827-Plat 12:15 pm THE ROLE OF CELLULAR REPLICATIVE LIFESPAN AND STEM CELL DYNAM- ICS ON CORNEAL EPITHELIUM HOMEOSTASIS AND PATTERN FORMATION. Lior Strinkovsky, Evgeni Havkin, Yonatan Savir 828-Plat 12:30 pm 4D CELL BIOLOGY: BIG DATA IMAGE ANALYTICS AND LATTICE LIGHT-SHEET IMAGING REVEAL DYNAMICS OF CLATHRIN-MEDIATED ENDOCYTOSIS IN STEM CELL-DERIVED INTESTINAL ORGANOIDS.  Johannes Schöneberg , Daphné Dambournet, Tsung-Li Liu, Ryan Forster, Dirk Hockemeyer, Eric Betzig, David G. Drubin Platform Protein Structure and Conformation II 10:45 am - 12:45 pm, Room 314/315 Co-Chair Andrea Soranno, Washington University in St. Louis Gwladys Riviere, University of Florida 829-Plat 10:45 am SINGLE-MOLECULE CONFORMATIONAL ANALYSIS OF APOLIPOPROTEIN E. Melissa D. Stuchell-Brereton, Berevan Baban, Greg DeKoster, Carl Frieden, Andrea Soranno 830-Plat 11:00 am A NEW STEP TO ELUCIDATE MOLECULAR MECHANISMS INVOLVED IN CARIES FORMATION: NMR CHARACTERIZATION OF THE C3 DOMAIN FROM STREPTOCOCCUS MUTANS ADHESIN P1.  Gwladys Riviere , Joanna Long, Jeanine Brady 831-Plat 11:15 am FIBRIL STRUCTURE OF ABETA40 VISUALIZED BY CRYO-ELECTRON MICROS- COPY AND SOLID-STATE NMR.  Ujjayini Ghosh , Robert Tycko 832-Plat 11:30 am MOLECULAR MODELING OF THE ALPHA GLOBIN/ENOS COMPLEX VIA CROSSLINKING MASS SPECTROMETRY.  T. C. Stevenson Keller , Brant E. Isakson, Linda Columbus 833-Plat 11:45 am HYDROGEN EXCHANGE MASS SPECTROMETRY GUIDED DOCKING GEN- ERATES ATOMIC RESOLUTION EPITOPES FOR SINGLE-CHAIN CAMELID ANTIBODY-ANTIGEN COMPLEXES.  Jing Zhou , Jeliazko Jeliazkov, Yuqi Shi, David Weis, Jeff Gray 834-Plat 12:00 pm REVEALING MULTIPLE CONFORMATIONS OF PROTEINS AT LONG DISTANCES BY USING SINGULAR VALUE DECOMPOSITION METHOD IN PULSED DIPOLAR ESR SPECTROSCOPY. Madhur Srivastava , Jack H. Freed 835-Plat 12:15 pm COEVOLUTIONARY LANDSCAPES OF KINASE FAMILY PROTEINS.  Allan Haldane , Peng He, William F. Flynn, Ronald M. Levy

836-Plat 12:30 pm STRUCTURE BASED SEARCH FOR MULTIPLE BINDING SITES OF SOS1 PR DOMAIN RECOGNIZES AN UNCOVERED MOTIF FAVORING GRB2-SOS1 ASSOCIATION.  Tsung-Jen Liao , Hyunbum Jang, Ruth Nussinov, David Fushman Platform Membrane Pumps, Transporters, and Exchangers 10:45 am - 12:45 pm, Room 316/317 Co-Chairs Jacob Keller, HHMI Rachelle Gaudet, Harvard University 837-Plat 10:45 am ON THE NATURE OF THE HIGH-AFFINITY IODIDE BINDING SITE OF THE NA + /I - SYMPORTER (NIS).  Silvia Ravera , Juan P. Nicola, Xuelang Mu, Igna- cia Echeverría, Yuly E. Sanchez, L. Mario amzel, Nancy Carrasco 838-Plat 11:00 am AN ELECTROSTATIC SWITCH FOR GATING THE ELECTROMECHANICAL ACTIVITY OF SLC26A5 (PRESTIN).  Dominik Oliver , Dmitry Gorbunov, Julia Hartmann, Dominik Lenz, Vijay Renigunta 839-Plat 11:15 am MECHANICS OF AN NRAMP-FAMILY TRANSITION METAL TRANSPORTER.  Aaron T. Bozzi, Christina M. Zimanyi, Lukas B. Bane, John M. Nicoludis, Brandon K. Lee, Casey H. Zhang, Rachelle Gaudet 840-Plat 11:30 am TRAVEL AWARDEE A MULTIDRUG AND TOXIN EFFLUX (MATE) TRANSPORTER INVOLVED IN ALUMINUM RESISTANCE IS MODULATED BY A CBL5/CIPK2 CALCIUM SEN- SOR/PROTEIN KINASE COMPLEX.  Julia Miller , Alison Coluccio, Jan Niklas Offenborn, Anette Mähs, Jörg Kudla, Leon Kochian, Miguel Piñeros 841-Plat 11:45 am THE NEW “PATCH CLAMPING” FOR TRANSPORTERS: OSCILLATING PERFU- SION AND QUANTITATIVE FUNCTIONAL IMAGING OF BIOSENSORS FOR TRANSPORTER FUNCTIONAL MEASUREMENTS.  Jacob P. Keller 842-Plat 12:00 pm ALLOSTERIC MODULATION OF ATP HYDROLYSIS OF THE MOUSE P-GLYCO- PROTEIN BY SUBSTRATES AND INHIBITORS.  Reza Dastvan , Smriti Mishra, Yelena B. Peskova, Robert K. Nakamoto, Hassane S. Mchaourab 843-Plat 12:15 pm VACUOLAR H + -ATPASE IN THE NUCLEAR MEMBRANES REGULATE NU- CLEO-CYTOSOLIC PROTON GRADIENTS.  Raul Martinez-Zaguilan , Juliana Santos, Arnoldo Facanha, Souad R. Sennoune 844-Plat 12:30 pm TRAVEL AWARDEE STRUCTURAL INSIGHTS INTO THE FUNCTION AND AUTO-REGULATION OF LIPID FLIPPASES.  Joseph A. Lyons , Milena Laban, Dovile Januliene, Jakob Ulstrup, Cedric Montigny, Thibaud Dieudonne, Valentine Guinot, Werner Kuehlbrandt, Guillaume Lenoir, Arne Moeller, Poul Nissen Annual Meeting of the Student Chapters 11:00 am - 12:30 pm, Room 324/325/326 BPS Student Chapter members are invited to attend the Student Chapter Meeting! At the event, Student Chapters from around the world will ex- change best practices (and share challenges!) in marketing their chapters and recruiting members, performing community outreach in science, and hosting chapter events. This event is open only to students currently in a BPS Student Chapter. Moderators Allen Price, Emmanuel College Seth Weinberg, Virginia Commonwealth University

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