Biophysical Society 63rd Annual Meeting | Program Guide

880-Plat TRAVEL AWARDEE NOVEL TALES ABOUT THE MYOSIN VI TAIL.  Natalia Fili , Alexander Cook, Yukti Hari Gupta, Christopher P. Toseland 881-Plat 5:45 pm FUNCTIONAL IMPLICATIONS OF DCM END-TO-END BOND MUTATION IN A-TROPOMYOSIN.  Alice Ward Racca , Nicholas LaFave, Stephanie Jones, Michael J. Rynkiewicz, William Lehman, Jeffrey R. Moore Platform Intrinsically Disordered Proteins (IDP) and Aggregates II 4:00 pm - 6:00 pm, Room 314/315 Co-Chairs 5:30 pm CHANGES TO THE INTRACELLULAR MILIEU CONTROL THE POPULATION AND RESIDUAL STRUCTURE OF UNFOLDED PROTEINS.  Yuhang Wang, Caitlin Davis, Alex S. Holehouse, Martin Gruebele, Shahar Sukenik 883-Plat 4:15 pm EVOLUTION OF THE INTRINSICALLY DISORDERED ACTIVATION DOMAIN IN A HOX TRANSCRIPTION FACTOR.  Ying Liu, Annie Huang, Rebecca Booth, Gabriela Mendes, Zabeena Merchant, Kathleen S. Matthews, Sarah E. Bondos 884-Plat 4:30 pm CONFORMATIONAL EFFECTS OF A DISEASE-ASSOCIATED HYDROPHOBIC- TO-HYDROPHOBIC SUBSTITUTION AND HISTIDINE PROTONATION STATE LOCATED AT THE MIDPOINT OF THE INTRINSICALLY DISORDERED REGION OF PROBDNF.  Ruchi Lohia , Grace Brannigan 885-Plat 4:45 pm A PROLINE SWITCH EXPLAINS KINETIC HETEROGENEITY IN A COUPLED FOLDING AND BINDING REACTION.  Franziska Zosel , Davide Mer- cadante, Daniel Nettels, Benjamin Schuler 886-Plat 5:00 pm SEQUENCE-BASED FINGERPRINTING OF INTRINSICALLY DISORDERED REGIONS.  Garrett M. Ginell , Megan C. Cohan, Alex S. Holehouse 887-Plat 5:15 pm FUNCTIONAL ADAPTATION MUTATIONS ALTER PROPENSITY FOR ALPHA- HELICAL CONFORMATION IN THE INTRINSICALLY DISORDERED GLU- COCORTICOID RECEPTOR TAU1CORE ACTIVATION DOMAIN.  Lennart Nilsson , Anthony Wright, Kyou-Hoon Han 888-Plat 5:30 pm THE DISORDERED PROTEIN BUGZ CONSERVES MITOTIC FUNCTION AND LIQUID-LIQUID PHASE SEPARATION ACROSS 1.6 BILLION YEARS OF EVO- LUTION.  Alexander F. Chin , Vincent J. Hilser, Yixian Zheng 889-Plat 5:45 pm TRAVEL AWARDEE PROBING SPECIFICITY IN DISORDERED PROTEIN INTERACTIONS WITH SMALL MOLECULES USING INTEGRATIVE METHODS.  Gabriella T. Heller , Francesco A. Aprile, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Michele Vendruscolo Franziska Zosel, Novo Nordisk, Denmark Sarah Bondos, Texas A&M University 882-Plat 4:00 pm

868-Plat 4:30 pm FUNCTIONAL AND STRUCTURAL ANALYSIS OF CELL-FREE SYNTHESIZED MEMBRANE PROTEINS.  Belay Gessesse , Takuya Ueda, Yoshihiro Shi- mizu 869-Plat 4:45 pm SPONGE MODEL OF G-PROTEIN BINDING AND UNBINDING IN MEM- BRANES.  Anna R. Eitel , Steven D.E. Fried, Suchithranga M.D.C. Perera, Udeep Chawla, Nipuna Weerasinghe, Carolanne E. Norris, Andrey V. Struts, Michael F. Brown 870-Plat 5:00 pm TRAVEL AWARDEE MECHANISM OF SPECIFIC G PROTEIN COUPLING TO ADENOSINE RECEP- TORS.  Jinan Wang , Yinglong Miao 871-Plat 5:15 pm STUDYING STRUCTURAL PLASTICITY UNDERLYING GPCR FUNCTION.  Matthew T. Eddy 872-Plat 5:30 pm A CONDITIONAL TRANSMEMBRANE PEPTIDE INHIBITS CELL MIGRATION BY ACTIVATION OF THE EPHA2 RECEPTOR TYROSINE KINASE.  Daiane S. Alves, Justin M. Westerfield, Xiaojun Shi, Vanessa P. Nguyen, Katherine M. Stefanski, AdamW. Smith, Francisco N. Barrera 873-Plat 5:45 pm TOWARDS MOLECULAR SIMULATIONS OF JUXTAPOSED BIOMEM- BRANES.  Elizabeth E. Jefferys , Bart Bruininks, Paulo Cesar T. Souza, Siewert-Jan Marrink, Mark S. Sansom Platform Myosin and Skeletal/Smooth Muscle Mechanics, Structure, and Regulation 4:00 pm - 6:00 pm, Room 309/310 Co-Chairs Wolfgang Linke, University of Muenster, Germany Aikaterini Kontrogianni-Konstantopoulos, University of Maryland Balti- more 874-Plat 4:00 pm MACROMOLECULAR CROWDING AFFECTS THE RATE OF ADP RELEASE FROM ACTOMYOSIN.  Jinghua Ge , Akhil Gargey, Yuri Nesmelov 875-Plat 4:15 pm THE MUSCLE MYOSIN ESSENTIAL LIGHT CHAIN IS NOT ESSENTIAL FOR MUSCLE FUNCTION.  Douglas M. Swank , Bernadette M. Glasheen 876-Plat 4:30 pm THE SKELETAL MUSCLE SUPER RELAXED STATE (SRX) IS LOCALIZED TO THE C-ZONE.  Shane R. Nelson , amy Li, Guy Kennedy, Samantha Beck- Previs, David M. Warshaw 877-Plat 4:45 pm THE LONG GLU-RICH SEGMENTS OF TROPONIN T IN FLIGHT MUSCLES OF BIRDS AND INSECTS.  Tianxin Cao , J.-P. Jin, Hanzhong Feng, Deena Damschroder, Robert Wessells 878-Plat 5:00 pm THIN FILAMENT REGULATION BLENDS THERMODYNAMIC AND MECHANICAL MECHANISMS.  Henry G. Zot , P. Bryant Chase, Javier E. Hasbun, J. Renato Pinto 879-Plat 5:15 pm ELUCIDATING PRINCIPLES OF MOLECULAR ELASTICITY IN MUSCLE FILAMENT PROTEINS: FROM HIGH-RESOLUTION STRUCTURE TO IN VIVO PROOF.  Philipp Hornburg, Spyros D. Chatziefthimiou, Matthias Wilmanns

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