Biophysical Society 63rd Annual Meeting | Program Guide

927-Pos Board B29 TOWARDS THE INHIBITION OF CALPAIN-DEPENDENT DESMOPLAKIN CLEAVAGE IN ARRHYTHMOGENIC CARDIOMYOPATHIES. Taylor Albertelli , Kendahl Ott, Heather R. Manring, Stuart G. Campbell, Maegen Borzok, Nathan T. Wright 928-Pos Board B30 CRYO-EM STRUCTURAL ANALYSIS OF NEURONAL NITRIC OXIDE SYN- THASE. Thomas H. Pospiech , Yoshihiro Morishima, Yoichi Osawa, Daniel R. Southworth 929-Pos Board B31 USING 4-CYANOPHENYLALANINE TO PROBE THE DEGREE OF WATER EXPOSURE IN A PEPTIDE HYDROGEL. Benjamin F. Frost , William E. Fox, Fiona Berry, Katherine Chung, Karin Akerfeldt 930-Pos Board B32 EVALUATION OF THE HIV GENOME TO PROMOTE GAG HEXAMERIZA- TION. Noel Getachew 931-Pos Board B33 OBSCURIN ACTS AS A SEMI-FLEXIBLE CHAIN IN SOLUTION.  Jake Whitley , Aidan Ex-Willey, Daniel Marzolf, Oleksandr Kokhan, Maegen Ackermann, Anthony Tongen, Nathan T. Wright 932-Pos Board B34 LARGE-SCALE ALL-ATOM SIMULATIONS OF T4P FILAMENTS REVEAL CRITI- CAL INTERACTIONS FOR T4P STABILITY. Rebecca B. Goncalves, Nicolas Biais, Joseph L. Baker 933-Pos Board B35 EFFECTS OF LOCAL AND GLOBAL DYNAMICS ON THE SUPERTERTIARY ORGANIZATION OF POSTSYNAPTIC DENSITY PROTEIN 95. George L. Hamilton , Jakub Kubiak, Claus A.M. Seidel, Hugo Sanabria Protein Stability, Folding, and Chaperones I (Boards B36 - B60) 934-Pos Board B36 UV PEROXIDATION REDUCES POLOXAMINE T1107 CAPABILITY TO DISAG- GREGATE LYSOZYME. Michelle X. Ling , Colin A. Mcfaul, Raphael C. Lee 935-Pos Board B37 NEW APPROACH TO EVALUATING THE STABILITY OF ANTIBODIES USING CIRCULAR DICHROISM SPECTROSCOPY SCREENING. Satoko Suzuki , Yasuo Horiguchi, Leah Pandiscia, Koushi Nagamori, Hiroshi Nakayama, Kouhei Board B38 PROBING (UN)FOLDING TRANSITION PATHS OF FAST-FOLDING PRO- TEINS BY SINGLE-MOLECULE FLUORESCENCE: EXPLORING THE ROLE OF SECONDARY STRUCTURE, FOLD TOPOLOGY AND SEQUENCE. Nivin Mothi , Mourad Sadqi, Victor Munoz 937-Pos Board B39 MONITORING DYNAMICS OF PROTEIN NASCENT CHAIN ON THE RIBO- SOME USING PET-FCS. Marija Liutkute , Ekaterina Samatova, Manisankar Maiti, Wolf H. Holtkamp, Jörg Enderlein, Marina V. Rodnina 938-Pos Board B40 ENHANCED PH DEPENDENT MODULATION OF ALPHA CRYSTALLIN CHAPERONE FUNCTION AND SUBUNIT EXCHANGE IN AN N-TERMINAL PHOSPHORYLATION MIMIC. Kashmeera Baboolall, Belelot Birhanu, Nata- lie Braun, Yusrah Kaudeer, Patricia B. O’Hara 939-Pos Board B41 H20Y MUTATION STABILIZES STRUCTURE OF THE PRIMARY DNA RECOG- NITION DOMAIN OF THE SLEEPING BEAUTY TRANSPOSASE. Chenbo Yan , Gage O. Leighton, Janna Lustig, Zoltán Ivics, Irina V. Nesmelova Tsumoto 936-Pos

940-Pos Board B42 A STRUCTURAL, DYNAMIC, AND THERMODYNAMIC EXPLANATION OF THERMOSTABILITY IN A DE NOVO DESIGNED THREE-HELIX BUNDLE. Nata- li Gonzalez, Emily Hamlin, Parwana Khazi, Catrina Nguyen, Jennifer Young, Michelle E. McCully 941-Pos Board B43 LONG-RANGED PROTEIN-GLYCAN INTERACTIONS STABILIZE VON WIL- LEBRAND FACTOR A2 DOMAIN FROMMECHANICAL UNFOLDING.  Chuqiao Dong , Jumin Lee, Seonghoon Kim, Whitney Lai, Edmund B. Webb, Alparslan Oztekin, Xiaohui Zhang, Wonpil Im 942-Pos Board B44 STUDYING THE FOLDING BEHAVIOR OF A 3D LATTICE PROTEIN UNDER OSCILLATORY CONDITIONS. Qizhang Jia , Xuanye Zhu, Austin Cheng, Cory J. Kim, Amy Y. Wang, Kateri H. DuBay 943-Pos Board B45 A COMPREHENSIVE INVESTIGATION OF THE STABILIZATION OF MONO- MERIC HFGF1 BY HEPARIN HEXASACCHARIDE USING MICROSECOND- LEVEL MD SIMULATIONS AND ENHANCED SAMPLING TECHNIQUES. Vivek Govind Kumar , Shilpi Agrawal, T.K.S. Kumar, Mahmoud Moradi 944-Pos Board B46 IDENTIFYING INTERMEDIATE STATES IN PRION PROTEIN FOLDING PATHWAY: A POSSIBLE PRECURSOR TO THE MISFOLDED STATE ? Balaka Board B47 DISULFIDE BONDS MODULATE LYSOZYME FOLDING PATHWAYS. Aswathy Muttathukattil Narayanan 946-Pos Board B48 PROBING THE CHAPERONE ACTIVITY OF ERYTHROID SPECTRIN. Dipayan Bose , Abhijit Chakrabarti 947-Pos Board B49 MOLTENPROT: A HIGH-THROUGHPUT ANALYSIS PLATFORM TO ASSESS THERMODYNAMIC STABILITY OF MEMBRANE PROTEINS AND COM- PLEXES. Vadim Kotov , Oliver Vesper, Maria Garcia Alai, Christian Loew, Thomas C. Marlovits 948-Pos Board B50 STRUCTURAL DYNAMICS OF C-MYB DNA-BINDING DOMAIN REVEALED BY DXT AND THERMAL ANALYSIS. Satomi Inaba , Yuhi Hosoe, Yuji C. Sasaki, Hiroshi Sekiguchi, Masayuki Oda 949-Pos Board B51 THE EARLIEST STAGES OF A PROTEIN’S LIFE INFLUENCES ITS LONG-TERM SOLUBILITY AND STRUCTURAL ACCURACY. Matthew D. Dalphin , Angela Varela, Andrew Stangl, Robert Kirchdoerfer, Rayna Addabbo, Yoo Jin Song, Yue Liu, Silvia Cavagnero 950-Pos Board B52 N-HXMS: A METHOD TO DIRECTLY MEASURE PROTEIN FOLDING AND STABILITY UNDER NATIVE CONDITIONS. Nejc Nagelj , Minjee Kim, Kaeli Mathias, Sheila Jaswal 951-Pos Board B53 INVESTIGATING THE EFFECTS OF MISSENSE MUTATIONS IN MSH2 GENE ASSOCIATED WITH LYNCH SYNDROME. Bohua Wu , Yunhui Peng, Julia A. Eggert, Emil Alexov 952-Pos Board B54 UNSUPERVISED LEARNING FOR DECOY SELECTION IN PROTEIN STRUC- TURE PREDICTION. Nasrin Akhter , Gopinath Chennupati, Hristo Djidjev, Amarda Shehu 953-Pos Board B55 BIOPHYSICAL CHARACTERIZATION OF DIFFERENCES IN DOMAIN-DOMAIN INTERACTIONS BETWEEN THE APOLIPOPROTEIN E4 AND E3. Subhrajyoti Dolai , Kanchan Garai Mondal 945-Pos

M O N D A Y

70