Biophysical Society 65th Annual Meeting Program Guide

Platform Ligand-gated Channels 10:00 am - 11:30 am

Platform Mitochondria and Energy 10:00 am - 11:30 am

T H U R S D A Y

Chair Andrea Brüggemann, Nanion Technologies, Germany No Abstract 10:00 am

Chair Edward Lyman, University of Delaware, USA 936-Plat 10:00 am MEMBRANE FLUIDITY: BOTH FUNDAMENTAL AND FUNCTIONAL. Edward Lyman 937-Plat 10:30 am THE SPATIO-TEMPORAL ORGANIZATION OF MITOCHONDRIAL F1FO-ATP SYNTHASE IS DETERMINED BY ITS ACTIVITY AND CONTROLLED BY IF1. Karin B. Busch , Kirill Salewskij, Bettina Rieger, Verena Weissert, Frances Hager, Tasnim Arroum, Sara Cogliati, Christian P. Richter, Olympia E. Psathaki, Thomas Zobel, José A. Enríquez, Timo Dellmann 938-Plat 10:45 am TRACKING MOTILITY AND MORPHOLOGY OF INDIVIDUAL MITOCHON- DRIA REVEALS LARGE HETEROGENEITIES IN BREAST CANCER SUBTYPES. Austin E.Y.T. Lefebvre , Dennis Ma, Kai Kessenbrock, Devon A. Lawson, Michelle A. Digman 939-Plat 11:00 am WETTING TRANSITIONS IN THE ATP SYNTHASE C-SUBUNIT RING, A LARGE-CONDUCTANCE ION CHANNEL. Rachel J. Dotson, Nelli Mnat- sakanyan, Elizabeth A. Jonas, Sally C. Pias 940-Plat 11:15 am ΑSYNUCLEIN REGULATES MITOCHONDRIAL CALCIUM TRANSPORT THROUGH THE VOLTAGE DEPENDENT ANION CHANNEL. WilliamM. Rosencrans , Vicente M. Aguilella, Tatiana K. Rostovtseva, Sergey M. Bezrukov Platform Molecular Dynamics and Bioinformatics II 10:00 am - 11:30 am Chair Aleksandra Walczak, École Normale Supérieure, France 941-Plat 10:00 am RESPONSE IN IMMUNE REPERTOIRES. Aleksandra M. Walczak 942-Plat 10:30 am DEVELOPMENT OF A HYBRID NEURAL NETWORK/MOLECULAR MECHAN- ICS APPROACH FOR METALLOPROTEIN SIMULATIONS. Bettina Lier , Peter Poliak, Julia Westermayr, Philipp Marquetand, Chris Oostenbrink 943-Plat 10:45 am ENHANCED SAMPLING OF RNA FOLDING/UNFOLDING CONFIGURATIONS USING MACHINE LEARNING/GRAND CANONICAL MONTE CARLO. Mert Y. Sengul , Abhishek A. Kognole, Alexander D. MacKerell 944-Plat 11:00 am AMPLIFICATION-FREE DETECTION OF VIRUSES IN MINUTES USING SINGLE-PARTICLE IMAGING AND MACHINE LEARNING. Nicolas Shiaelis , Leon Peto, AndrewMcMahon, Chritof Hepp, Erica Bickerton, Cyril Favard, Delphine Muriaux, Monique Andersson, Alison Vaughan, Philippa Mat- thews, Nicole Stoesser, Derrick Crook, Achillefs N. Kapanidis, Nicole C. Robb 945-Plat 11:15 am COMPUTING ABSOLUTE FREE ENERGY WITH DEEP GENERATIVE MODELS. Xinqiang Ding , Bin Zhang

THE ABC AND D OF NMDA RECEPTORS AS POTENTIAL TARGETS FOR THE TREATMENT OF DEPRESSION AND CHRONIC PAIN. Andrea Brüggemann 928-Plat 10:30 am STRUCTURAL BASIS OF FUNCTIONAL TRANSITIONS IN MAMMALIAN NMDA RECEPTORS. Tsung-Han Chou , Nami Tajima, Annabel Romero- Hernandez, Hiro Furukawa 929-Plat 10:45 am HETEROGENEOUS POPULATIONS OF LIGAND-GATED ION CHANNEL, GLIC, REVEALED BY CRYO-ELECTRON MICROSCOPY AND SIMULATIONS. Urska Rovsnik , Yuxuan Zhuang, Bjorn Forsberg, Marta Carroni, Linnea Axelsson, Christian Blau, Rebecca J. Howard, Erik R. Lindahl 930-Plat 11:00 am STRUCTURES OF HUMAN PROTON-ACTIVATED CHLORIDE CHANNEL (PAC) REVEAL MECHANISM OF PH SENSING AND GATING. James Osei-Owusu , Zheng Ruan, Juan Du, Wei Lu, Zhaozhu Qiu 931-Plat 11:15 am ROLE OF D-SERINE BINDING TO THE NMDA RECEPTOR LIGAND-BINDING DOMAIN. Remy A. Yovanno , Albert Y. Lau Platform Cytoskeletal Assemblies, Cell Mechanics, Mechanosensing and Motility 10:00 am - 11:30 am Chair Erika Holzbaur, University of Pennsylvania, USA No Abstract 10:00 am NAVIGATING COMPLEX CYTOSKELETAL ARRAYS: KINESIN MOTILITY ALONG BIPOLAR MICROTUBULES IN DENDRITES. Erika Holzbaur 932-Plat 10:30 am PATIENT-DERIVED GLIOBLASTOMA (GBM) CELLS EXHIBIT DISTINCT RHEO- LOGICAL PROFILES ASSOCIATED WITH ALTERED CYTOSKELETON REGULA- TION. Amelia Foss , Woong Young So, Michael M. Gottesman, Kandice Tanner 933-Plat 10:45 am NON-LINEAR MECHANICAL RESPONSE TRANSFORMS A GRADED MO- LECULAR DISTRIBUTION INTO A STEP-WISE OUTPUT IN CELL BEHAVIOR. Sourabh Bhide, Denisa Gombalova, Johannes Stegmaier, Gregor Moenke, Julio M. Belmonte , Maria Leptin 934-Plat 11:00 am HIERARCHICAL BAYESIAN 3D TRACTION FORCE MICROSCOPY WITH LO- CAL REGULARIZATION BASED ON IMAGE QUALITY. Adithan Kandasamy , Yi-Ting Yeh, Amy B. Schwartz, Juan C. Lasheras, Juan C. del Alamo 935-Plat 11:15 am DIFFERENTIAL ADHESION AND PERIODIC OSCILLATIONS OF MYOSIN-II MECHANICALLY PROOFREAD FILOPODIA INTERACTIONS DURING EMBRY- ONIC HEART FORMATION. Timothy E. Saunders , Shaobo Zhang, Sham Tlili

64