Biophysical Society 65th Annual Meeting Program Guide

1165-Pos B oard B215 ROLE OF THE NMDAR-NR2B SUBUNIT IN THE FUNCTION OF SUPRA- MOLECULAR NMDAR-BK COMPLEXES. Rebeca Martínez Lázaro , David Bartolome-Martin, Ricardo Gomez, Teresa Giraldez 1166-Pos B oard B216 DEVELOPMENT AND OPTIMIZATION OF CALCIUM FLUORESCENT SEN- SORS BASED ON BK ION CHANNELS. David Bartolome-Martin , Roger Gimeno, Belinda Rivero-Perez, Alejandro Cerrada, Alberto J. Gonzalez- Hernandez, Diego Alvarez de la Rosa, Teresa Giraldez 1167-Pos B oard B217 CURRENT REGULATION IN POTASSIUM CHANNELS. Wojciech Kopec , Andrei Mironenko, Ben Goold, Bert L. de Groot 1168-Pos B oard B218 A HYDROPHOBIC PATCH IN THE PAS-CAP ALPHA-HELIX IS CRITICAL FOR SLOW DEACTIVATION IN HERG CHANNELS. Whitney A. Stevens-Sostre , Lisandra Flores Aldama, Gail A. Robertson 1169-Pos B oard B219 NON-CANONICAL MECHANISM OF THE VSD-PD COUPLING IN KCNQ1/ KCNE1 CHANNELS. Xiaoan Wu , Marta E. Perez, Peter H. Larsson 1170-Pos B oard B220 DESIGN OF A CHIMERIC KCNQ1 CHANNEL FOR E. COLI EXPRESSION AND STUDIES OF LQTS VARIANTS. Kathryn R. Brewer , Hope Woods, Georg Kuenze, Charles R. Sanders 1171-Pos B oard B221 VOLTAGE-SENSING MECHANISM OF NEURONAL KCNQ CHANNELS. Michaela Edmond , Marta E. Perez, Rene Barro-Soria 1172-Pos B oard B222 VOLTAGE ACTIVATION MECHANISMS OF EPILEPSY- AND ASD-ASSOCIATED MUTATIONS IN NEURONAL KCNQ CHANNELS. Andy Hinojo-Perez , Marta E. Perez, Rene Barro-Soria 1173-Pos B oard B223 STRUCTURAL DETERMINANTS FOR RUBIDIUM BINDING AFFINITY IN THE SELECTIVITY FILTER OF POTASSIUM CHANNELS. D. Marien Cortes, Luis G. Cuello 1174-Pos B oard B224 INVESTIGATION OF THE INACTIVATION OF HERG USING MOLECULAR DYNAMICS SIMULATIONS OF NEW CRYO-EM STRUCTURES. Emelie Flood , Caurus Lau, Mark Hunter, Chai-An Ng, Eduardo Perozo, Toby W. Allen, Jamie I. Vandenberg 1175-Pos B oard B225 PIP2 INDUCED CONFORMATIONAL CHANGES IN KIR CHANNELS - A MOLECULAR DYNAMICS STUDY. Michael Bründl , Sarala Pellikan, Anna Stary-Weinzinger 1176-Pos B oard B226 THE ROLE OF D AND E HELICES IN HCN CHANNELS. Alessandro Porro , Federica Gasparri, Viviana Prota, Gerhard Thiel, Federico Thei, Bina San- toro, Andrea Saponaro, Anna Moroni 1177-Pos B oard B227 STRUCTURAL REQUIREMENTS FOR THE STABILITY AND TRAFFICKING OF THE KCNQ1 POTASSIUM CHANNEL. Hui Huang , Alfred L. George, Charles R. Sanders 1178-Pos B oard B228 DIFFERENTIAL HERG SUBUNIT TRANSCRIPTION DRIVES CHANGES IN I KR DURING CARDIAC MATURATION. Chiamaka U. Ukachukwu , André Mon- teiro Da Rocha, Eric N. Jiménez-Vázquez, Abhilasha Jain, David K. Jones

1179-Pos B oard B229 INFORMING NMR EXPERIMENTS WITH MOLECULAR DYNAMICS SIMULA- TIONS TO CHARACTERIZE THE DOMINANT OPEN STATE OF KCSA. Sergio Pérez Conesa , Eric G. Keeler, Ann E. McDermott, Lucie Delemotte 1180-Pos B oard B230 STRUCTURAL MODELING OF THE HERG CHANNEL IN AN INACTIVATED STATE AND ASSOCIATED DRUG INTERACTIONS. Jan Maly , Aiyana M. Emigh, Kevin DeMarco, Jon T. Sack, Igor V. Vorobyov, Colleen E. Clancy, Vladimir Yarov-Yarovoy 1181-Pos B oard B231 STRUCTURAL CHANGES IN KIR3.2 CHANNELS LEADING TO LOSS OF K + SE - LECTIVITY. Theres Friesacher, Harald Bernsteiner, Anna Stary-Weinzinger 1182-Pos B oard B232 A SECOND S4 MOVEMENT OPENS HYPERPOLARIZATION-ACTIVATED HCN CHANNELS. Rosamary Ramentol , Marta E. Perez, Peter Larsson 1183-Pos B oard B233 MODULATION OF VENTRICULAR CARDIOMYOCYTES ELECTROPHYSIOL- OGY BY GLYPICAN 1 HEPARAN SULFATE PROTEOGLYCAN. Diego Souza, Andreia Chignalia, Joao L. Carvalho-de-Souza 1184-Pos B oard B234 QUANTUM CALCULATIONS ON THE ROLE OF TWO AMINO ACID GROUPINGS THAT INCLUDE THREE POSITIVE, TWO NEGATIVE CHARGED RESIDUES ON THE TRANSPORT OF PROTONS IN THE VOLTAGE SENSING DOMAIN OF THE K V 1.2 POTASSIUM CHANNEL. Alisher M. Kariev , Michael B oard B235 COVID-19 DRUGS CHLOROQUINE AND HYDROXYCHLOROQUINE, BUT NOT AZITHROMYCIN AND REMDESIVIR, BLOCK HERG POTASSIUM CHAN- NELS. Mark Szendrey, Jun Guo, Wentao Li, Tonghua Yang, Shetuan Zhang Ion Channels, Pharmacology, and Disease (Boards B236 - B252) 1186-Pos B oard B236 AGE-DEPENDENT INTERCALATED DISC PERINEXAL NARROWING CON- CEALS LONG-QT SYNDROME TYPE 3 PHENOTYPE. Xiaobo Wu , Robert G. Gourdie, Gregory Hoeker, Seth H. Weinberg, Steven Poelzing 1187-Pos B oard B237 CHLORPROMAZINE ANALOGUES BIND TO PAS DOMAIN AND INHIBIT EAG POTASSIUM CHANNELS. Ze-Jun Wang , Tinatin I. Brelidze 1188-Pos B oard B238 AN ASYMMETRIC C-TYPE INACTIVATED STRUCTURE OF HERG CHANNEL AND ITS BINDING TO CHEMICALLY DIVERSE DRUGS. Jing Li , Rong Shen, Eduardo Perozo, Benoit Roux 1189-Pos B oard B239 MOLECULAR DETERMINANTS OF D AND L-SOTALOL STEREOSELECTIVE PROARRHYTHMIA PROCILIVTIES. Kevin R. DeMarco, Pei-Chi Yang, Kazuha- ru Furutani, John R.D. Dawson, Slava Bekker, Van A. Ngo, Sergei Y. Noskov, Vladimir Yarov-Yarovoy, Jon T. Sack, Colleen E. Clancy, Igor Vorobyov 1190-Pos B oard B240 ELECTROPHYSIOLOGICAL ANALYSIS OF THE CARDIAC KV CHANNEL WITH THE NEW POINT MUTATION FOUND IN THE PATIENT WITH LQTS. Julia Kacher , Maria Karlova, Valeria Rusinova, Denis Abramochkin ⁠ , Elena Zakly- azminskaya, Olga Sokolova 1191-Pos B oard B241 SINGLE CHANNEL BIOPHYSICAL PROPERTIES OF THE LEFT VENTRICULAR MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX. Lucile Fossier , Ma- thieu Panel, Albano C. Meli, Jeremy Fauconnier, Alain Lacampagne E. Green 1185-Pos

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