Biophysical Society 66th Annual Meeting Program Guide

1137-Pos Board B278 REGULATION OF CARDIAC ACTION POTENTIAL DURATION BY NEU - ROTRANSMITTERS AND CO-TRANSMITTERS. Shailesh R. Agarwal , Chase M. Fiore, Kalyanam Shivkumar, Robert D. Harvey 1138-Pos Board B279 INTEGRATED ELECTROPHYSIOLOGIC ANALYSES OF AMIODARONE IN HUMAN IPSC-DERIVED CARDIOMYOCYTES. Druv Bhagavan , Jonathan D. Moreno, Divya C. Kernik, Jingxuan Guo, Nathaniel Huebsch, Jonathan R. Silva 1139-Pos Board B280 RATIOMETRY FOR IMPROVING THE SIGNAL-TO-NOISE WITH THE RED- SHIFTED VOLTAGE DYE DI4ANBDQBS. Anthony Costantino , Brian K. Panama, Mark W. Nowak, Randall L. Rasmusson, Glenna Bett 1140-Pos Board B281 EFFECT OF THE MEMBRANE ENVIRONMENT ON PHARMACOLOGIC INHIBITION OF HERG CHANNEL ACTIVITY. Chase M. Fiore, Kate Quigley, Colleen E. Clancy, Robert D. Harvey 1141-Pos Board B282 PRELOAD-INDUCED CARDIOMYOCYTE CALCIUM OVERLOAD AND VENTRICULAR DAMAGE IN ISOLATED HEARTS FROM YOUNG DUCHENNE MUSCULAR DYSTROPHY (DMD MDX-4CV ) MICE. Vivian Onyali 1142-Pos Board B283 TOWARDS A MICROFLUIDIC DEVICE FOR INVESTIGATING NEURALLY MEDIATED CARDIAC WAVE DYNAMICS. Karissa Becknel 1143-Pos Board B284 AGING IMPAIRS THE ASSOCIATION AND MODULATION OF L-TYPE CALCI - UM CHANNELS BY Β2 ADRENERGIC RECEPTORS IN CARDIAC PACEMAKER CELLS. Sabrina Choi , Oscar Vivas, Matthias Baudot, Claudia M. Moreno 1144-Pos Board B285 COMPUTATIONAL MODELING OF THE EFFECTS OF DRUGS IN HCM AND DCM CARDIOMYOPATHIES. Srboljub M. Mijailovich , Momcilo Proda - novic, Corrado Poggesi, Michael Regnier, Michael A. Geeves 1145-Pos Board B286 HOMEOSTATIC CONTROL OF CARDIAC EXCITABILITY BY AN RNA-BASED MECHANISM. Erick B. Rios Perez 1146-Pos Board B287 AGING IMPAIRS THE CLUSTERING AND REDUCES THE ACTIVITY OFL-TYPE CALCIUM CHANNELS IN THE HEART'S PACEMAKER. Matthias Baudot , Oscar Vivas, Sabrina Choi, Gabriella Serrano, Claudia M. Moreno 1147-Pos Board B288 LOADED RELAXATION INDUCE DAMAGE IN MOUSE MODEL OF MUSCU - LAR DYSTROPHY. Nancy S. Saad , Kyra Peczkowski-Weishaar, Jonathan P. Davis, Paul M. Janssen 1148-Pos Board B289 COMPARISON OF LEFT VERSUS RIGHT VENTRICULAR CONTRACTION PROFILE IN FAILING AND NON-FAILING ISOLATED HUMAN MYOCARDI - UM. Mohammed Mashali , Tom Fanning, Nancy S. Saad, Paul M. Janssen 1149-Pos Board B290 COMBINING IN-SILICO CARDIAC ACTION POTENTIALS WITH HERG CUR - RENTS EXPRESSED IN HEK CELLS USING DYNAMIC CLAMP IN SYNTHETIC CELL MODE. Mark W. Nowak , Leigh Korbel, Alex Kane, Brian K. Panama, Glenna Bett, Randall L. Rasmusson 1150-Pos Board B291 EXPRESSION OF SARS-COV-2-ORF3A PROTEIN INDUCES CARDIOMYO - CYTE DAMAGE. Iuliia A. Polina , Yugene Guo, Michael W. Cypress, Elena G. Tolkacheva, Bong Sook Jhun, Jin O-Uchi

1125-Pos Board B266 SPATIAL AND FUNCTIONAL HETEROGENEITY AMONG PACEMAKER CELL POPULATIONS INCREASES ROBUSTNESS AND FLEXIBILITY OF SA NODE TISSUE PACEMAKER FUNCTION IN SILICO. Alexander V. Maltsev , Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev 1126-Pos Board B267 REDUCED SARCOPLASMIC RETICULUM CA 2+ PUMP ACTIVITY IS ANTI-AR - RHYTHMIC IN ISCHEMIC CARDIOMYOPATHY. An Xie , Hong Liu, Gyeoung- Jin Kang, Feng Feng, Samuel C. Dudley 1127-Pos Board B268 REDUCED EPHAPTIC COUPLING EXACERBATES CONDUCTION SLOWING IN THE SCN5A HETEROZYGOUS MOUSE. Grace Blair , Steven Poelzing 1128-Pos Board B269 Travel Award Winner OPTOGENETIC SUPPRESSION OF DRUG-INDUCED EARLY AFTERDEPOLAR - ISATIONS IN THE ZEBRAFISH HEART. Ahmed F. Ramadan , T. Alexander Quinn 1129-Pos Board B270 A COMPUTATIONAL MODEL OF SINGLE VASCULAR SMOOTH MUSCLE CELL ELETROPHYSIOLOGY. Gonzalo Hernandez Hernandez , Samantha C. O'Dwyer, Collin Matsumoto, L. F. Santana, Colleen E. Clancy 1130-Pos Board B271 GENETIC ALGORITHM-ASSISTED IDENTIFICATION OF IONIC CURRENT CONDUCTANCE ABNORMALITIES IN IN-SILICO HUMAN ATRIAL CAR - DIOMYOCYTES. Henry Sutanto , Alexander P. Clark, Drew C. Tilley, Trine Krogh-Madsen, David J. Christini 1131-Pos Board B272 INVOLVEMENT OF THE PURKINJE FIBRES IN THE DEVELOpmENT OF VEN - TRICULAR ARRHYTHMIAS UPON MECHANICAL STIMULATION. Miriam E. Hurley , Sarbjot Kaur, Amelia Power, Richard D. Walton, Michel Haïssa - guerre, Olivier Bernus, Marie-Louise Ward, Ed White 1132-Pos Board B273 INTERCALATED DISK NANOSCALE STRUCTURE AND ION CHANNEL LO - CALIZATION REGULATE CARDIAC CONDUCTION. Nicolae Moise , Heather Struckman, Rengasayee Veeraraghavan, Seth H. Weinberg 1133-Pos Board B274 OPENING OF REMODELED CX43 HEMICHANNELS PROMOTE ARRHYTH - MIAS AND VENTRICLE INFARCTION UPON Β ADRENERGIC STRESS. OPENING OF CX43 HEMICHANNELS PROMOTE ARRHYTHMIAS AND VENTRICLE INFARCTION UPON B-ADRENERGIC STRESS. Mauricio A. Lillo, Lai-Hua Xie, Diego Fraidenraich, Jorge E. Contreras 1134-Pos Board B275 TACKLING CHRONIC COMPOUND RESPONSES OF HIPSC-CMS FOR PRE - CLINICAL CARDIAC RISK EVALUATION: DEFINED SERUM-FREE MEDIUM AND LONG-TERM CULTURE ON THE FLEXCYTE 96. Matthias Gossmann, Bettina Lickiss, Marta Lemme, Elena Dragicevic, Ravi Vaidyanathan, Peter Linder, Ulrich Thomas, Sonja Stoelzle-Feix, Michael George, George O. Okeyo, Ronald Knox , Rodolfo Haedo, Niels Fertig 1135-Pos Board B276 AUTOMATED 3D RECONSTRUCTION OF ISOLATED MITOCHONDRIA FROM CARDIOMYOCYTE SBEM IMAGES. Asuka Hatano , Makoto Someya, Hiroaki Tanaka, Hiroki Sakakima, Satoshi Izumi, Masahiko Hoshi - jima, Mark Ellisman, Andrew D. McCulloch 1136-Pos Board B277 ELECTRICAL ACTIVITY IN EXERCISE TRAINED INFARCTED RAT HEARTS. Tomas O. Stolen , Anne Berit Johnsen, Mathias Nyman, Karin Garten, Allen Kelly, Francis L. Burton, Godfrey L. Smith, Jan Pål Loennechen

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