Biophysical Society 66th Annual Meeting Program Guide

Voltage-Gated K Channels I (Boards B292 - B314)

1164-Pos Board B305 BIOPHYSICAL AND MOLECULAR STUDIES OF AN EPILEPSY RELATED SINGLE-POINT MUTANT IN THE S4-S5 LINKER OF THE KV7.3 SUBUNIT OF M-CHANNEL. Argel Estrada Mondragon , Michael Pökl, Emma Kindström, Fredrik Elinder 1165-Pos Board B306 ENDOCANNABINOID-LIKE COMPOUNDS AS MODULATORS OF THE CAR - DIAC KV7.1/KCNE1 CHANNEL. Irene Hiniesto Iñigo , Siri Lundholm, Johan E. Nikesjö, Sara I. Liin 1166-Pos Board B307 COMPREHENSIVE FUNCTIONAL EVALUATION OF KCNE1 VARIANTS USING AUTOMATED PATCH CLAMP RECORDING. Carlos G. Vanoye , Reshma R. Desai, Nirvani Jairam, Nora Ghabra, Jens Meiler, Charles R. Sanders, Alfred L. George 1167-Pos Board B308 PROTEIN PROTEIN INTERACTIONS OF KCNQ1 AND KCNE1 OBSERVED VIA SDSL EPR LINE SHAPE ANALYSIS. Rebecca Stowe , Gunjan Dixit, Indra D. Sahu, Alison Bates, Carole Dabney-Smith, Gary A. Lorigan 1168-Pos Board B309 DISEASE ASSOCIATED CAM VARIANTS INTERACT WITH KCNQ1 TO CON - FER ABERRANT MEMBRANE TRAFFICKING AND FUNCTION. Po wei Kang, Lucy S. Woodbury , Paweorn Angsutararux, Namit Sambare, Jingyi Shi, Martina Marras, Carlota Abella, Anish Bedi, DeShawn Zinn, Jianmin Cui, Jonathan R. Silva 1169-Pos Board B310 THE EXPRESSION, PURIFICATION, AND SITE-DIRECTED SPIN-LABELING OF KCNE4. Alison Bates , Indra D. Sahu, Carole Dabney-Smith, Gary A. Lorigan 1170-Pos Board B311 OPENING OF KCNQ2 CHANNELS DOES NOT REQUIRE CONCERTED MOVE - MENT OF ALL FOUR VOLTAGE SENSORS. Andy Hinojo-Perez , Marta E. Perez, Rene Barro-Soria 1171-Pos Board B312 ELECTROPHYSIOLOGICAL CHARACTERIZATION OF HCN1 CHANNELS VARI - ANTS LINKED TO HUMAN EPILEPSY. Alessandro Porro , Gerardo Abbando - nato, Alberto Russo, Bina Santoro, Anna Moroni 1172-Pos Board B313 TWO EPILEPSY-ASSOCIATED MUTATIONS AT SAME SITE IN K V 1.2 ( KCNA2 ) OPPOSITELY AFFECT CHANNEL FUNCTIONAL EXPRESSION. Teresa Minguez Vinas , Varsha Prakash, Sarah H. Lindström, Cecilia Gunnarsson, Antonios Pantazis 1173-Pos Board B314 ENDOCANNABINOID REGULATION OF KIR2.1 INWARD RECTIFIER POTAS - SIUM CHANNELS. Ameneh Ahrari, Sultan Mayar, Niveny Sinniah, Mina Memarpoor-Yazdi, Nazzareno D'Avanzo Ligand-Gated Channels I (Boards B315 - B331) 1174-Pos Board B315 A RELIABLE AND AFFORDABLE FLUORESCENCE CELL-IMAGING ASSAY FOR DISCOVERY OF GLYCINERGIC THERAPEUTICS. Qiang Chen , Tommy S. Till - man, Lingling Jiang, Nicole Brandon, Yan Xu, Pei Tang 1175-Pos Board B316 USING PROTEIN SEMI-SYNTHESIS TO IDENTIFY PROTON-SENSING RESIDUES IN AN ACID-SENSING ION CHANNEL. Debayan Sarkar , Iacopo Galleano, Stephan A. Pless

M O N D A Y

1151-Pos Board B292 ASSOCIATED MRNAS COORDINATE BIOGENESIS OF FUNCTIONALLY RE - LATED ION CHANNELS. Margaret B. Jameson , Catherine A. Eichel, Erick B. Rios Perez, Fang Liu, Avtar S. Roopra, Gail A. Robertson 1152-Pos Board B293 IDENTIFICATION AND VALIDATION OF A NUCLEAR LOCALIZATION SE - QUENCE IN THE HERG1 POTASSIUM CHANNEL. Abhilasha Jain , Chiamaka Ukachukwu, Saba Ghodrati, Matt C. Trudeau, David K. Jones 1153-Pos Board B294 TRIVALENT LANTHANIDES AFFECT GATING OF THE HERG POTASSIUM CHANNEL AT LOWMICROMOLAR CONCENTRATIONS. Nina E. Ottosson , Fredrik Elinder 1154-Pos Board B295 VOLTAGE DEPENDENT BLOCK OF THE CARDIAC POTASSIUM CHANNEL HERG BY CALCIUM AND HYDROGEN. Alan Miller , Justin D. Nguyen 1155-Pos Board B296 OPTIMIZATION OF NOVEL LEAD COMPOUNDS FOR TREATMENT OF LONG QT SYNDROME. Jessica Jowais , Laura Castro Glez, Peter H. Larsson, Peter Tieleman, Marta E. Perez 1156-Pos Board B297 FUNCTIONAL UPREGULATION OF HERG1B ION CHANNELS BY DIRECT INTERACTIONS WITH THE HERG1A N-TERMINAL PAS DOMAIN AND N- LINKER REGIONS. Taylor R. Crawford , Ashley A. Johnson, Matt C. Trudeau 1157-Pos Board B298 PAS AND CNBH DOMAIN INTERACTIONS IN HERG CHANNELS INVESTI - GATED WITH SURFACE PLASMON RESONANCE. Stephanie M. Soohoo , Purushottam B. Tiwari, Yuichiro J. Suzuki, Tinatin I. Brelidze 1158-Pos Board B299 Travel Award Winner CONFORMATION SENSITIVE ANTIBODY REVEALS AN ALTERED CYTOSOLIC PAS/CNBH ASSEMBLY DURING HERG CHANNEL GATING. Whitney A. Stevens-Sostre , Carol A. Harley, Ganeko Bernardo-Seisdedos, David K. Jones, Maria M. Azevedo, Paula Sampiao, Marta Lorga-Gomes, Matt C. Trudeau, Oscar Millet, Gail A. Robertson, Joao H. Morais Cabral 1159-Pos Board B300 STEPS OF TEMPERATURE JUMPS RELIEVE INACTIVATION OF HERG. Carlos Alberto Z. Bassetto Jr , Bernardo Pinto, Ramon Latorre, Francisco Board B301 C-TERMINAL DOMAIN INFLUENCES THE GATING POLARITY OF CNBD FAMILY OF ION CHANNELS. Jenna L. Lin , Gurmeet Kaur, Yongchang Chang, Debanjan Tewari, John Cowgill, Aravind Iyer, Baron Chanda 1161-Pos Board B302 THE EFFECTS OF LONG QT SYNDROME ASSOCIATED MUTATION R231C ON THE CARDIAC IKS CHANNEL. Yahnell Judah , Xiaoan Wu, Marta E. Perez, H. Peter Larsson 1162-Pos Board B303 MODULATORY ROLE OF OKG ON DELAYED RECTIFIER POTASSIUM CHAN - NELS IN VENTRICULAR CARDIOMYOCYTES FROMMETABOLIC SYNDROME RATS. Erkan Tuncay , YUSUF OLGAR, Aysegul Durak, Ceylan Verda Bitirim, Belma Turan 1163-Pos Board B304 Travel Award Winner HUMAN K V 7 CHANNEL SUBTYPES ARE DIFFERENTIALLY MODULATED BY CANNABIDIOL. Damon J.A. Frampton , Michael Pökl, Veronika Linhart, Irene Hiniesto Iñigo, Sara I. Liin Bezanilla 1160-Pos

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