Biophysical Society 66th Annual Meeting Program Guide

1176-Pos Board B317 PROBING THE ACTIVATION MECHANISMS OF A MUSCLE-TYPE ACE - TYLCHOLINE RECEPTOR USING A COMBINATION OF STRUCTURAL AND FUNCTIONAL MEASUREMENTS. Mackenzie J. Thompson , John E. Travel Award Winner FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF A NOVEL PH-MODULATED OPEN STATE OF A PENTAMERIC LIGAND-GATED ION CHANNEL. Urska Rovsnik , Olivia Andén, Marie Lycksell, Marc H. De - larue, Rebecca J. Howard, Erik R. Lindahl 1178-Pos Board B319 Travel Award Winner CRYO-EM AND SMALL-ANGLE SCATTERING OF A PENTAMERIC LIGAND- GATED ION CHANNEL REVEALS A DYNAMIC REGULATORY DOMAIN. Marie Lycksell , Urska Rovsnik, Anton Hanke, Rebecca J. Howard, Erik R. Lindahl 1179-Pos Board B320 IMPACT OF SARS-COV-2 SPIKE PROTEIN ON Α7 NICOTINIC ACETYLCHO - LINE RECEPTOR IN CELLS. Tommy S. Tillman, Yan Xu, Pei Tang 1180-Pos Board B321 GLYCINE OR D-SERINE ACTIVATION OF DELTA SUBTYPE OF IONOTROPIC GLUTAMATE RECEPTOR. Elisa Carrillo , Cuauhtemoc U. Gonzalez, Vlad - mir Berka, Vasanthi Jayaraman 1181-Pos Board B322 LSM12, AN NAADP RECEPTOR, IS ALSO A PI(3,5)P2-COMPETITIVE ANTAGONIST OF HUMAN TWO PORE CHANNELS. Canwei Du , Kunal R Shah, Jiusheng Yan 1182-Pos Board B323 ATOMIC MODELS FROM LOW RESOLUTION MAPS WITH DENSITY-GUID - ED MD SIMULATIONS. John Cowgill , Linnea Yvonnesdotter, Christian Blau, Rebecca J. Howard, Erik R. Lindahl, Lucie Delemotte 1183-Pos Board B324 CONCANAVALIN A BIDING TO HOMOMERIC GLUK2 RECEPTOR LEADS TO CLOSER PROXIMITY OF THE EXTRACELLULAR DOMAINS. Cuauhtemoc U. Gonzalez , Elisa Carillo, Vladimir Berka, Vasanthi Jayaraman 1184-Pos Board B325 ALLOSTERIC CONTROL OF NMDA RECEPTOR CALCIUM PERMEABILITY BY EXTRACELLULAR PROTONS. AdamM. Weaver 1185-Pos Board B326 HETEROTRIMERIC CONCATAMERS OF IONOTROPIC P2X4 AND P2X7 RECEPTORS. Malte Berthold , Sanaria Hawro Yakoob, Guenther Schmalz - ing, Fritz Markwardt 1186-Pos Board B327 INTERACTION INTERFACE BETWEEN PENTAMERIC NEUROTRANSMIT - TER-GATED ION CHANNELS AND RIC-3 CHAPERONE. Hoa Quynh Do , Michaela Jansen 1187-Pos Board B328 DIFFERENTIAL EFFECTS OF DILTIAZEM ON RETINAL CNG CHANNELS: THERAPEUTIC IMPLICATIONS FOR RETINITIS PIGMENTOSA . Valerie Popp, Kathrin Groeneveld, Christian Melle, Frank Schwede, Vasilica Nache 1188-Pos Board B329 DISTINCT CONFORMATIONAL DYNAMICS OF NMDAR SUBTYPES. Julia Bleier , Cherise Stanley, Ehud Y. Isacoff 1189-Pos Board B330 ELECTRICAL CHARACTERIZATION OF THE SHORT AND LONG GAMMA SUBUNIT SPLICE VARIANTS OF HUMAN GABA A RECEPTORS. Nathan Hunt , Ona McConnell, Eric Wang, Ali Yehia Baenziger 1177-Pos Board B318

1190-Pos Board B331 MAPPING THE BINDING SITE OF NS309, A SUPERAGONISTIC POSI - TIVE GATING MODULATOR FOR THE CALCIUM-ACTIVATED POTASSIUM CHANNEL KCA3.1. Joshua Nasburg , Heesung Shim, Heike Wulff Other Channels (Boards B332 - B348) 1191-Pos Board B332 THE ROLE OF PHE150 IN HUMAN VOLTAGE-GATED PROTON CHAN - NEL. Xin Wu, Liang Hong 1192-Pos Board B333 UNEXPECTED EXPANSION OF THE VOLTAGE-GATED PROTON CHANNEL FAMILY. Gustavo Chaves, Artem Ayuyan, Vladimir V. Cherny, Deri Mor - gan, Arne Franzen, Lynne A. Fieber, Lydia Nausch, Christian Derst, Iryna Mahorivska, Christophe Jardin, Thomas E. DeCoursey, Boris Musset 1193-Pos Board B334 WATER MOVEMENT DURING PERMEATION PROCESS IN CIHV1 CHAN - NEL. Juan J. Alvear , Miguel Fernandez, Ramon Latorre, Jose Garate, Carlos L. Gonzalez 1194-Pos Board B335 NEW ISOFORMS OF MHV1 CHANNEL IN MYELOID-DERIVED SUPPRES - SOR CELLS. Antonio Peña-Pichicoi , Juan J. Alvear, Christian A. Carrillo- Soto, Emerson M. Carmona, Miguel Fernández, Jose Garate, Angelica M. Lopez-Rodriguez, Carlos L. Gonzalez 1195-Pos Board B336 H V 1 CHANNEL IS A KEY TARGET IN IMMUNOSUPPRESSION IN MYELOID- DERIVED SUPPRESSOR CELLS (MDSC). Christian A. Carrillo-Soto , Juan J. Alvear, Antonio Peña-Pichicoi, Miguel Fernández, Emerson M. Carmona, Alan Neely, Osvaldo Alvarez, José A. Gárate, H. Peter Larsson, Angelica M. Lopez-Rodriguez, Ramon Latorre, Carlos L. Gonzalez 1196-Pos Board B337 PROTON CURRENTS THROUGH HV1 CHANNELS CHARACTERIZE MYELOID-DERIVED SUPPRESSOR CELLS. Marco Cozzolino 1197-Pos Board B338 MULTIPLE MECHANISMS CONTRIBUTE TO FLUOROMETRY SIGNALS FROM THE VOLTAGE-GATED PROTON CHANNEL. Ferenc Papp, Gilman E. Toombes, Zoltan Denes Petho, Adrienn Bagosi, Adam Feher, Janos Almassy, Akos Kuki, Sandor Keki, Gyorgy Panyi, Zoltan Varga 1198-Pos Board B339 SUBTYPE-SPECIFIC GATING MECHANISMS OF OTOP CHANNELS BY PRO - TONS. Bochuan Teng , Yu-Hsiang Tu, Joshua Kaplan, Ziyu Liang, Zachary Krieger, Emily R. Liman 1199-Pos Board B340 MECHANISTIC UNDERSTANDING OF LYSOSOMALMECHANISTIC UNDER - STANDING OF LYSOSOMAL INTEGRAL MEMBRANE PROTEIN-2 (LIMP-2/ SCARB2)-MEDIATED CHOLESTEROL TRANSPORT REGULATION. Shuheng Huang , Régis Pomès, Anna Liang, Richard L. Banh, Jingjing Huang 1200-Pos Board B341 STRUCTURAL AND FUNCTIONAL COMPARISON OF CATION-SELECTIVE CLAUDIN CHANNELS. Ridaka Wal Jannat , Pan Li, Ye Li, Le Shen, Christo - pher Weber, Fatemeh Khalili-Araghi 1201-Pos Board B342 SMALL MOLECULE PERMEATION THROUGH A WIDE-PORE CHANNEL VIA APPLIED VOLTAGE AND MARKOVIAN MILESTONING. YiChun Lin , Wenjuan Jiang, Yun Lyna Luo

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