Biophysical Society 66th Annual Meeting Program Guide

Cardiac and Smooth Muscle Regulation (Boards B369 - B389) 1228-Pos Board B369 PHOSPHOMIMETIC MUTATIONS IN THE C-TERMINAL BASIC REGION OF TROPONIN T INCREASES ACTIN FILAMENT ACTIVITY. Li Zhu, Maicon Landim-Vieira, Michelle C. Rodriguez Garcia , J. Renato D. Pinto, Joseph M. Chalovich 1229-Pos Board B370 EVIDENCE FOR NOVEL PHOSPHORYLATION SITES IN THE CENTRAL C4-C5 DOMAINS OF MURINE CARDIAC MYOSIN BINDING PROTEIN C. Chang Yoon Doh , Katherine L. Dominic, Caitlin E. Swanberg, Nikhil Bharambe, Ling Li, Belinda Willard, Rajesh Ramachandran, Julian E. Stelzer 1230-Pos Board B371 Travel Award Winner MICROTUBULES MAINTAIN PASSIVE TENSION AND MYOFIBRIL FORMA - TION IN DEVELOPING CARDIOMYOCYTES. Eesha Murali , Abigail Nagle, Dasom Yoo, Ketaki N. Mhatre, Michael Regnier 1231-Pos Board B372 DEOXYATP PRODUCING HIPSC DERIVED CARDIOMYOCYTE TO RESTORE CARDIAC FUNCTION IN HEART FAILURE. Ketaki N. Mhatre , Farid Moussavi-Harami, Julie Mathieu, Stephen D. Hauschka, Charles E. Murry, Michael Regnier 1232-Pos Board B373 SELECTIVE ABLATION OF THE LONG SPLICE VARIANT OF STIM1 INHIBITS SOCE, PREVENTS CARDIAC HYPERTROPHY, AND CAUSES SEVERE CAR - DIAC IMPAIRMENT AND PREMATURE DEATH IN EXERCISED MICE. Benjamin Hernandez Orengo , Ingrid M. Bonilla, Galina Sakuta, Den - nison Min, Stephen Baine, Andriy E. Belevych, Cynthia A. Carnes, Przemyslaw Radwanski, Sandor Gyorke 1233-Pos Board B374 STRUCTURE-BASED DISCOVERY OF ACTIN-BINDING DRUGS. Scout Allendorf , Anna Wilson, Chandini Nair, David D. Thomas, Piyali Guha - thakurta 1234-Pos Board B375 SPATIALLY-EXPLICIT MODELING FRAMEWORK FOR PREDICTING THE DOSE-DEPENDENT EFFECTS ON CONTRACTION OF MYOTROPES. Chandler Zhu , Sarah Kosta, Kenneth S. Campbell 1235-Pos Board B376 UNDERSTANDING THE MOLECULAR BASIS OF HCM-CAUSING MUTA - TIONS IN CARDIAC MYOSIN AND CARDIAC MYOSIN BINDING PROTEIN- C. Divya Pathak , Neha Nandwani, Kathleen Ruppel, James A. Spudich 1236-Pos Board B377 CONTRACTION-RELAXATION COUPLING IS UNALTERED BY HEART FAILURE STATUS IN HUMAN MYOCARDIUM. Farbod Fazlollahi , Amanda Huang, Nick Yavornitzky, Anna Wang, Kyra Peczkowski-Weishaar, Nancy S. Saad, Mohammed Mashali, Austin Hare, Courtney Campbell, Bryan A. Whitson, Nahush Mokadam, Paul M. Janssen 1237-Pos Board B378 CHRONIC CARDIAC TROPONIN I PHOSPHORYLATION IN HEART FAIL - URE. Vani S. Ravichandran, Tabea M. Schatz, Paige Reynolds, Margaret V. Westfall 1238-Pos Board B379 Travel Award Winner THE HCM I79N PATHOGENIC VARIANT IN CARDIAC TNT INDUCES THICK FILAMENT MALFUNCTION AND MYOFILAMENT LATTICE REARRANGE - MENT. Maicon Landim-Vieira , Weikang Ma, Taejeong Song, Coen A. Ottenheijm, Hyun S. Hwang, Henry M. Gong, Maria Papadaki, Bjorn C. Knollmann, Sakthivel Sadayappan, Thomas C. Irving, Prescott B. Chase, J. Renato Pinto

1239-Pos Board B380 SARCOMERE GENERATION IS LOCALIZED TO INTERCALATED DISK AND DEPENDENT ON STORE OPERATED CA 2+ ENTRY IN A MODEL OF RAPID ONSET (TAKOTSUBO) HYPERTROPHY. Casey M. Beard , Benjamin Her - nandez Orengo, Vladimir Bogdanov, Galina Sakuta, Jonathan P. Davis, Sandor Gyorke 1240-Pos Board B381 CALCIUM EXCHANGE WITH TROPONIN C IN HYPERTROPHIC CARDIOMY - OPATHY. MatthewM. Klass , Jonathan P. Davis, Jil C. Tardiff 1241-Pos Board B382 MECHANISM OF CALCIUM SENSITIVITY MODULATION OF CARDIAC TROPONIN C BY SMALL MOLECULES ILLUMINATED BY UMBRELLA SAM - PLING SIMULATIONS. Steffen Lindert 1242-Pos Board B383 DISSECTING CARDIAC MYOSIN-BINDING PROTEIN C INTERACTIONS ON A SYNTHETIC Β-CARDIAC MYOSIN DNA NANOTUBE THICK FILA - MENT. Anja M. Touma, Duha Vang , Wanjian Tang, David Rasicci, Ashim Rai, Samantha B. Previs, David M. Warshaw, Christopher M. Yengo, Sivaraj Sivaramakrishnan 1243-Pos Board B384 SPATIALLY AND FUNCTIONALLY DISTINCT POOLS OF CALMODULIN MRNA IN CARDIAC MYOCYTES. Vladimir Bogdanov , AndrewM. Soltisz, Benjamin Hernandez Orengo, Galina Sakuta, Rengasayee Veeraragha - van, Jonathan P. Davis, Sandor Gyorke 1244-Pos Board B385 MULTISCALE CHARACTERIZATION OF FOUR TROPOMYOSIN-1 VARI - ANTS OF UNKNOWN SIGNIFICANCE. Michael J. Rynkiewicz , Jenette G. Creso, Xia Li, Lorenzo R. Sewanan, Darren Liu, Meaghan Barry, Jeffrey R. Moore, William Lehman, Stuart G. Campbell 1245-Pos Board B386 NOVEL TRANSMURAL PREPARATION FROM HUMAN FAILING HEARTS TO STUDY PHOSPHOPROTEINS. Amanda Huang , Farbod Fazlollahi, Brandon J. Biesiadecki, Bryan Whitson, Nahush Mokadam, Paul M. Janssen 1246-Pos Board B387 AN AUTISM SPECTRUM DISORDER-RELATED RISK GENE IMPACTS GUT TISSUE MECHANICS AND THE GUT MICROBIOME IN DROSOPHILA MELANOGASTER . Mikkel H. Jensen , Eliza J. Morris, Jeffery Cavanaugh, Prince Yadav, Nguyên Henry Võ, Chloe Welch, Aliyah Penn, Kimberly Mulligan 1247-Pos Board B388 UPON ADDITION OF MYOSIN LIGHT CHAIN PHOSPHATASE, CALDESMON CREATES A LOAD ON ACTIN FILAMENTS PROPELLED BY A MIXTURE OF SMOOTH AND SKELETAL MUSCLE MYOSIN. Matheus Schultz , Linda H. Kachmar, Megan J. Hammell, Gijs Ijpma, Anne-Marie Lauzon 1248-Pos Board B389 CAVEOLAE DEFORMATION INDUCES NUCLEAR RELOCALIZATION OF CAVIN-1 TO IMPACT TRANSCRIPTION. Androniqi Qifti , Shravani Balaji, Suzanne F. Scarlata Myosins (Boards B390 - B411) 1249-Pos Board B390 APPLICATION OF NEURAL-NETWORK-BASED DEEP-LEARNING ANALYSIS TO REVEAL CHANGES OF THE MOVEMENT PARAMETERS IN RAT NEURO - MUSCULAR DISORDER MODELS. Mate Winternitz , Mate Gyimesi, Adam I. Horvath, Mate Penzes, Andras Malnasi-Csizmadia

M O N D A Y

85