Biophysical Society 66th Annual Meeting Program Guide

1263-Pos Board B404 ESSENTIAL MYOSIN LIGHT CHAIN MLC-1SA DECELERATES ACTIN AND THIN FILAMENT GLIDING ON BETA-MYOSIN MOLECULES. Jennifer Osten , Maral Mohebbi, Tianbang Wang, Petra Uta, Theresia Kraft, Mamta Amrute-Nayak, Tim Scholz 1264-Pos Board B405 UTILIZATION OF COARSE GRAINED MODELING TO DETERMINE STRUC - TURAL CHANGES WITHIN CARDIAC CROSS-BRIDGING EVENTS. Anthony P. Baldo , Israel A. Mora, Jil C. Tardiff, Steven D. Schwartz 1265-Pos Board B406 CALCIUM DEPENDENCE OF MYO3B MOTOR FUNCTION. Laura K. Gunther , Joseph A. Cirilo Jr., Christopher M. Yengo 1266-Pos Board B407 DELINEATING THE DESIGN FEATURES UNDERLYING THE STEPPING MECHANISM OF CLASS X MYOSIN. Quang Quan Nguyen , Yangbo Zhou, Man Sze Cheng, Xianan Qin, Harry Chun Man Cheng, Xiaoyan Liu, H. Lee Sweeney, Hyokeun Park 1267-Pos Board B408 CHARACTERIZATION OF A FILOPODIAL MYOSIN. Casey W. Eddington , Margaret A. Titus 1268-Pos Board B409 INVESTIGATING THE EFFECTS OF MUTATIONS IN NON-MUSCLE MYO - SIN 2A LMM BY CIRCULAR DICHROISM AND ELECTRON MICROSCOPY ANALYSIS. David Casas-Mao , Glenn Carrington, Francine Parker, Marta Giralt-Pujol, Michelle Peckham 1269-Pos Board B410 STUDYING THE INTERACTING HEAD MOTIF IN FAST, SLOW, AND CARDIAC MYOFIBRILS IN STOPPED-FLOW. Jonathan Walklate , Michael Regnier, Michael A. Geeves 1270-Pos Board B411 DISSECTING PLASMODIUM FALCIPARUM MYOSIN A FUNCTION AND REGULATION: THE HIGHWAY TO DEVELOP NOVEL ANTIMALARIAL COM - POUNDS. Julien Robert-Paganin , Dihia Moussaoui, Anne M. Houdusse 1271-Pos Board B412 A MINIMAL MODEL PREDICTS CELL SHAPES AND TISSUE MECHANICS IN THE AMNIOSEROSA DURING DORSAL CLOSURE. Indrajit Tah , Daniel Haertter, Janice Crawford, Daniel P. Kiehart, Christoph Schmidt, Andrea Board B413 FORCE-MEDIATED CELLULAR ANISOTROPY AND PLASTICITY DICTATE THE ELONGATION DYNAMICS OF EMBRYOS. Chao Fang, Xi Wei, Xueying Shao, Yuan Lin 1273-Pos Board B414 PLEIOTROPIC EFFECT OF STATIN ON VASCULAR SMOOTH MUSCLE CELL MECHANICS AND MIGRATION. Alex Rickel, Hanna Sanyour, Zhongkui Hong 1274-Pos Board B415 MECHANICAL CONSTRAINT MODEL TO UNDERSTAND REMODELING IN BEATING CARDIAC MICROTISSUES. Dylan Mostert , Ignasi J. Masdeu, Robert P.C.J.J. Passier, Nicholas A. Kurniawan, Carlijn V.C. Bouten 1275-Pos Board B416 GEOMETRICAL CHARACTERIZATION OF ACTIVE CONTRACTION PULSES IN EPITHELIAL CELLS USING THE VERTEX MODEL. Fernanda L. Pérez , Ger - man Reig, Mauricio Cerda, Miguel Concha, Rodrigo Soto Jo-Wei Liu 1272-Pos Cell Mechanics, Mechanosensing, and Motility II (Boards B412 - B433)

1250-Pos Board B391 SKELETAL, SMOOTH AND CARDIAC MUSCLE MYOSIN 2 ARE LESS SENSI - TIVE FOR THE CHIRAL HYDROXYL MOIETY OF BLEBBISTATIN THAN THAT OF NON-MUSCLE MYOSIN 2 ISOFORMS. Anna Á. Rauscher , Mate Gyi - mesi, Andras Malnasi-Csizmadia 1251-Pos Board B392 RAPID REROUTING OF MYOSIN TRAFFIC AT THE T CELL IMMUNOLOGICAL SYNAPSE. Robert Mąka, Natalia Plewa, Urszula Cichoń, Katarzyna Kryszto - fiak, Jagoda Rokicka, Ronald S. Rock 1252-Pos Board B393 SIGNATURES OF ALLOSTERIC MODULATOR SPECIFICITY ARE ENCODED IN MYOSIN MOTOR DOMAIN EQUILIBRIUM FLUCTUATIONS. Artur Meller , Jeffrey M. Lotthammer, Catherine Kuhn, Michael J. Greenberg, Gregory Board B394 A MUTATION IN THE SWITCH 1 REGION OF MYOSIN VA ALTERS THE LOAD-DEPENDENCE OF PHOSPHATE REBINDING. Christopher P. Marang , Brent D. Scott, Laura K. Gunther, Christopher M. Yengo, Edward P. Debold 1254-Pos Board B395 THE ROLE OF NM2 REARRANGEMENT DURING CYTOKINESIS. Adam I. Horvath , Mate Gyimesi, Miklos Kepiro, Boglarka Varkuti, Andras Malnasi- Board B396 CRYO-EM STRUCTURE OF THE ASYNCHRONOUS FLIGHT MUSCLE THICK FILAMENT FROM THE BUMBLE BEE, BOMBUS IGNITIUS , AT 6 Å RESOLU - TION. Jiawei Li , Hamidreza Rahmani, Fatemeh Abbasi Yeganeh, Hosna Rastegarpouyani, Dianne W. Taylor, Hiroyuki Iwamoto, Kenneth A. Taylor 1256-Pos Board B397 DILATED CARDIOMYOPATHY MUTATION E525K IN HUMAN BETA-CARDIAC MYOSIN STABILIZES THE INTERACTING HEADS MOTIF AND SUPER-RE - LAXED STATE OF MYOSIN. David V. Rasicci, Prince Tiwari, Rohini Desetty, Fredrik Sadler, Sivaraj Sivaramakrishnan, Roger W. Craig, Christopher M. Yengo 1257-Pos Board B398 EXTRACTION OF A SINGLE MOLECULE WORK FROM EMSEMBLE SIGNAL OF VESICLE TRANSPORTATION BY MYOSIN INHIBITORS AND USING SINGLE OPTICAL TWEEZER. Takeshi Sakamoto , Justin J. Raupp, Hetviben Patel 1258-Pos Board B399 CHARACTERIZING BLEBBISTATIN POCKET CONFORMATIONAL DYNAM - ICS WITH MARKOV STATE MODELS. Borna Novak , Artur Meller, Gregory Board B400 EXPLORING THE MYOSIN ACTIVE/AUTO-INHIBITED STATE EQUILIBRIUM BY MARKOV STATE MODELING. Jeffrey M. Lotthammer , Artur Meller, Michael J. Greenberg, Gregory R. Bowman 1260-Pos Board B401 DROSOPHILA MYO-1C AND MYO-1D ARE HIGH DUTY RATIO MOTORS WITH VERY HIGH ADP AFFINITY. Faviolla A. Baez-Cruz , E. Michael Ostap 1261-Pos Board B402 NANOMETRE RESOLUTION STEPPING PATTERN AND STRUCTURE OF ACTO-MYOSIN-5A AT HIGH ATP REVEALS NEWMECHANISM FOR PRO - CESSIVE TRANSLOCATION. Yasuharu Takagi , Adam Fineberg, Kavitha Thirumurugan, Neil Billington, Joanna Andrecka, Gavin Young, Daniel Cole, James R. Sellers, Peter J. Knight, Philipp Kukura 1262-Pos Board B403 COMPUTATIONAL INTERPRETATION OF THE EFFECT OF OMECAMTIV MECARBIL ON THE RECOVERY STROKE OF HUMAN CARDIAC BETA MYO - SIN, USING METADYNAMICS. Ananya Chakraborti , Jil C. Tardiff, Steven D. Schwartz Bowman 1253-Pos Csizmadia 1255-Pos Bowman 1259-Pos

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