Biophysical Society 66th Annual Meeting Program Guide

1276-Pos Board B417 UNDERSTANDING AND STEERING CELL AND MATRIX ALIGNMENT IN COMPLEX MULTI-CUE ENVIRONMENTS. Cas van der Putten , Gitta B.C. Buskermolen, Maike Werner, Hannah F.M. Brouwer, Thomas E. Woud, Carlijn V.C. Bouten, Nicholas A. Kurniawan 1277-Pos Board B418 MULTIWELL COMBINATORIAL HYDROGEL ARRAY FOR HIGH-THROUGH - PUT ANALYSIS OF CELL-ECM INTERACTIONS. Ruoxing Lei, Erin A. Akins , Kelly Wong, Nicole Repina, Kayla J. Wolf, Garrett Dempsey, David Schaffer, Andreas Stahl, Sanjay Kumar 1278-Pos Board B419 GLOBAL COLLECTIVE INVASION OCCURS WITH MINIMAL EFFORT ON ALIGNED COLLAGEN FIBERS VIA LONG DISTANCE FORCE TRANSMISSION THROUGH SOFT MATRICES. Amrit Bagchi , Amit Pathak 1279-Pos Board B420 THE BROADCAST OF MECHANO-SIGNALING IN GLIOMA SPHEROID: PHYS - ICAL CONTACTS WITH MICROGLIA ALTER THE RESPONSE OF GLIOMA TO MECHANICAL STIMULI. Ping-Chen Kuo , Chih-Tung Liu, Megha Jhunjhun - wala, Rong-Shing Chang, Chi-Shuo Chen 1280-Pos Board B421 FORCE GENERATION MACHINERY IS EXPLOITED BY CANCER CELLS PRO - MOTING TUMOR PROGRESSION VIA ECM REMODELING AND IMMUNO - SUPPRESSION. Wei-Hung Jung, Seungman Park, Junjie Chen, Matthew Pittman, Yun Chen 1281-Pos Board B422 THE MOTILITY LANDSCAPE AND INTRA-PATIENT HETEROGENEITY IN GLIOBLASTOMA ARE EXPOSED BY TUMOR-SPHERE SPREADING ON MICROPATTERNS. Michele Crestani , Nikolaos Kakogiannos, Tania Dini, Giuliana Pelicci, Monica Giannotta, Elisabetta Dejana, Pascale Monzo, Nils C. Gauthier 1282-Pos Board B423 SLIDING HYDROGELS ENHANCE MSC CHONDROGENESIS BY FACILITATING EARLY STAGE CYTOSKELETAL/NUCLEAR DYNAMICS AND MECHANICAL LOADING. Manish Ayushman , Xinming Tong, Fan Yang 1283-Pos Board B424 THE ROLE OF CELL MECHANICS IN CHEMOTHERAPY-INDUCED METAS - TASIS. Sukhman Virdi, Nicholas Herrero, Israel Bryant, Destiny Jordan, Ashley Abraham, Gargee Khaparde, Megha Jacob, Chisom Nwakama, Andrew E. Ekpenyong 1284-Pos Board B425 ROLE OF CALPONIN 2 IN CELL MIGRATION AND MECHANOREGULA - TION. Imjoo Jang , Jian-Ping Jin 1285-Pos Board B426 PORE SPACING GRADIENT CAN DIRECT ENDOTHELIAL CELL MIGRATION IN MICROPHYSIOLOGICAL SYSTEMS. Zahra Allahyari , Shayan Gholizadeh, Moumita Das, Thomas R. Gaborski 1286-Pos Board B427 PUFF UP TO DECIDE: THE ROLE OF REGULATORY VOLUME CHANGES IN NEUTROPHIL POLARITY AND CHEMOTAXIS. Tamas L. Nagy , Orion D. Weiner 1287-Pos Board B428 MOLECULAR LOGIC OF FRONT-BACK COORDINATION IN MOVING NEU - TROPHILS. Suvrajit Saha , Orion D. Weiner 1288-Pos Board B429 TRANSENDOTHELIAL MIGRATION ALTERS SUBSEQUENT NEUTROPHIL IN - TERSTITIAL MIGRATION PHENOTYPE IN 3D MATRICES. Amy B. Schwartz , Adithan Kandasamy, Joshua Francois, Yi-Ting Yeh, Juan Carlos del Alamo

1289-Pos Board B430 MEMBRANE RUFFLING IS A MECHANOSENSOR OF EXTRACELLULAR FLUID VISCOSITY. Matthew Pittman , Ernest Iu, Keva Li, Junjie Chen, Sergey Potnikov, Yun Chen 1290-Pos Board B431 CELLULAR IRON STATUS INFLUENCES CELL MOTILITY IN GLIOBLASTO - MA. Ganesh Shenoy , Madison Kuhn, Kondaiah Palsa, Becky Slagle-Webb, Amanda M. Snyder, Chachrit Khunsriraksakul, Katie Troike, Justin D. Lathia, Hong-Gang Wang, Elizabeth A. Proctor, James R. Connor 1291-Pos Board B432 VISCOSITY DEPENDENCE ON THE GRAVIKINESIS OF A SWIMMING MICRO - ORGANISM. Ilyong Jung 1292-Pos Board B433 IMPACT OF SPATIAL PATTERN OF OBSTACLES ON FIRST PASSAGE OF AN ACTIVE PARTICLE. Moumita Dasgupta , Leon Armbruster, Sougata Guha, Mithun K. Mitra Molecular and Cellular Neuroscience (Boards B434 - B442) 1293-Pos Board B434 USING MICROSCOPY TECHNIQUES TO STRUCTURALLY CHARACTERISE TDP-43 INCLUSIONS PRESENT IN MAMMALIAN CELL MODELS. Naunehal S. Matharu , Chyi W. Chung, Janet R. Kumita, Gabriele S. Kamin - ski, Tuomas P. Knowles 1294-Pos Board B435 ELUCIDATING THE MECHANISM IN WHICH PROLINE MUTATIONS INDUCE TOXICITY IN PRION DISEASES. Amy M. Freiberg , Glenn L. Millhauser 1295-Pos Board B436 ELUCIDATION OF THE ENDOCYTIC PATHWAY OF AMYLOID-BETA(30) VIA THE CELLULAR PRION PROTEIN. Amanda Smart , Glenn L. Millhauser 1296-Pos Board B437 CRYSTAL STRUCTURE OF THE PRION PROTEIN REGULATORY DOMAIN IN COMPLEX WITH THE ALZHEIMER’S PEPTIDE. Irene C. Franco 1297-Pos Board B438 HOW DOES NEUROFILAMENT PHOSPHORYLATION REGULATE AXONAL OUTGROWTH AND STABILIZATION? Ibtissem Derouiche 1298-Pos Board B439 COMPLETE MODELING OF PRP C IN THE CIS INTERACTION EMPLOYING NOVEL TRANSPEPTIDATION. Francesca A. Pavlovici , Tufa Assafa, Hsiau- Wei Lee, Glenn L. Millhauser 1299-Pos Board B440 STRUCTURAL STUDY OF REGULATED INTRAMEMBRANE PROTEOLYSIS OF THE P75 NEUROTROPHIN RECEPTOR BY Γ-SECRETASE. Ka Yi Chan , Yu-Ping Poh, Po-Lin Chiu 1300-Pos Board B441 DIMERS ARE FOREVER: SINGLE-MOLECULE AND SUPERRESOLUTION MICROSCOPY SHINE LIGHT ON SINGLE-PROTEIN EXCHANGE WITHIN SYNAPTIC COMPLEXES - A POTENTIAL MECHANISM FOR LONG-TERM MEMORY STORAGE. Katie Morris , Noboru Komiyama, Edita Bulovaite, Seth G.N. Grant, Mathew H. Horrocks 1301-Pos Board B442 AMORTIZED INFERENCE OF BIOMOLECULE DYNAMICS WITH GRAPHS. Hippolyte Verdier , François Laurent, Vestergaard L. Christian, Jean-Baptiste Masson

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