Biophysical Society 66th Annual Meeting Program Guide

Platform Protein Dynamics and Allostery II 8:15 am - 10:15 am, South, Level Two, Room 201/202/203 Co-Chairs

Tuesday, February 22

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Registration/Information 7:30 am - 5:00 pm, South Lobby Biophysical Society Business Meeting 8:00 am - 9:00 am, Esplanade, Room 156 Poster Viewing 8:00 am - 4:00 pm, Exhibit Hall ABC Symposium Protein Degradation/Unfolded Protein Response 8:15 am - 10:15 am, South, Level Three, Room 301/302 Chair James Olzmann, University of California, Berkeley, USA 1377-Symp 8:15 am CO-TRANSLATIONAL STABILIZATION DRIVES FOLDING OF A MULTI-DOMAIN PROTEIN. Kevin Maciuba, Christian Kaiser No Abstract 8:45 am SPHINGOLIPIDS INITIATE THE ENDOPLASMIC RETICULUM STRESS RE- SPONSE. Maho Niwa Rosen No Abstract 9:15 am TARGETING THE CELL’S STRESS PATHWAYS FOR THERAPEUTIC BENEFIT. 9:45 am CELLULAR LIPID HOMEOSTASIS: FROM LIPID DROPLETS TO LIPOTOXICITY. James Olzmann Symposium Peripheral Membrane Proteins 8:15 am - 10:15 am, South, Level Three, Room 303/304 Chair Lucie Delemotte, KTH Royal Institute of Technology, Sweden 1378-Symp 8:15 am ACTIVE CONTROL OF PLASMA MEMBRANE COMPOSITION REGULATES MEMBRANE PROTEIN SIGNALLING. Satyajit Mayor 1379-Symp 8:45 am A EUKARYOTIC CIRCUIT FOR SECRETE AND SENSE AUTONOMY. Pradipta Ghosh , Lingxia Qiao, Amer A-H. Mohammed, Saptarshi Sinha, Padmini 9:15 am MECHANISTIC INSIGHTS INTO THE RECRUITMENT OF RAF KINASE TO THE PLASMA MEMBRANE BY KRAS. Andrew Stephen 1381-Symp 9:45 am DETAILS OF G-PROTEIN COUPLED RECEPTOR ACTIVATION VIA DATA- DRIVEN MOLECULAR MODELING. Lucie Delemotte , Oliver Fleetwood, Yue Chen, Sergio Pérez Conesa Peter Walter No Abstract Rangamani 1380-Symp

Yanxiao Han, University of California, Davis, USA Souvik Sinha, University of California, Riverside, USA 1382-Plat 8:15 am

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TIME-RESOLVED FUNCTIONAL EXPANSION OF VISUAL RHODOPSIN DETECTED BY X-RAY SCATTERING. C. Swathi K. Menon , Konstantinos Karpos, Thomas D. Grant, Andrey V. Struts, Steven D.E. Fried, Roberto C. Alvarez, Suchithranga M.D.C. Perera, Irina V. Kosheleva, Alan Grossfield, Petra Fromme, Richard A. Kirian, Michael F. Brown 1383-Plat 8:30 am UNRAVELING THE ALLOSTERIC ACTIVATION OF GPCR USING METADY- NAMICS AND DEEP LEARNING. Mahdi Ghorbani , Samarjeet Prasad, Bernard R. Brooks, Jeffery B. Klauda 1384-Plat 8:45 am ATOMISTIC UNDERSTANDING OF THE RNA-MEDIATED ALLOSTERIC CROSSTALK IN CAS13A. Souvik Sinha , Pablo R. Arantes, Aakash Saha, Giulia Palermo 1385-Plat 9:00 am MULTISCALE MODELING OF SYMPATHETIC CARDIOVASCULAR STIMULA- TION. Yanxiao Han , Gonzalo Hernandez-Hernandez, Pei-Chi Yang, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Igor V. Vorobyov 1386-Plat 9:15 am ANALYSIS AND PREDICTION OF TETR ALLOSTERY WITH MACHINE LEARN- ING METHODS AND A STATISTICAL MODEL. Zhuang Liu , Megan Leander, Srivatsan Raman, Qiang Cui 1387-Plat 9:30 am ALLOSTERIC POCKET PREDICTION IN PROTEINS EXTRACTED FROM THEIR CHARACTERISTIC MOTIONS. Ambuj Kumar , Burak Kaynak, Pemra Doruker, Robert L. Jernigan 1388-Plat 9:45 am FREE ENERGY ALONG TRANSITION PATHWAYS FROM CORRELATION BASED SAMPLING. Emmi Pohjolainen, Maxim Igaev, Helmut Grubmuller, Andrea C. Vaiana 1389-Plat 10:00 am MACHINE LEARNING FOR FUNCTIONAL DYNAMICS IN TEM BETA-LACTA- MASE PREDICTS INHIBITOR BINDING SITES. Christopher Avery , Donald J. Jacobs Platform Protein-Nucleic Acid Interactions II 8:15 am - 10:15 am, South, Level Two, Room 204/205/206 Co-Chairs Marialucrezia Losito, Imperial College London, United Kingdom Pengyu Zheng, Northeastern University, USA 1390-Plat 8:15 am SHORT TANDEM REPEATS RECRUIT TRANSCRIPTION FACTORS TO TUNE EUKARYOTIC GENE EXPRESSION. Connor A. Horton , Amr M. Alexandari, Michael G. Hayes, Julia M. Schaepe, Emil Marklund, Nilay Shah, Arjun K. Aditham, Avanti Shrikumar, Ariel Afek, William J. Greenleaf, Raluca Gordan, Julia Zeitlinger, Anshul Kundaje, Polly M. Fordyce 9,10

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