Biophysical Society 66th Annual Meeting Program Guide

1404-Plat 9:45 am SURFACE DENSITIES PREWET A NEAR CRITICAL MEMBRANE. Mason N. Rouches , Sarah L. Veatch, Benjamin B. Machta 1405-Plat 10:00 am THE MOLECULAR DETERMINANTS OF MEMBRANE VISCOSITY. James E. Fitzgerald , Edward R. Lyman Platform Myosins and Muscle Mechanics 8:15 am - 10:15 am, South, Level Two, Room 209/210/211 Co-Chairs Alexandra Hollo, NIH, USA Matthew A. Caporizzo, University of Pennsylvania, USA 1406-Plat 8:15 am MOLECULAR REGULATORY MECHANISMS OF HUMAN MYOSIN-7A. Alexandra Hollo , Neil Billington, Andras M. Kengyel, James R. Sellers, Rong Liu 1407-Plat 8:30 am CAPTURING THE PRE-POWER STROKE STRUCTURE OF ACTOMYOSIN V THROUGH TIME RESOLVED CRYO-ELECTRON MICROSCOPY. David P. Klebl, Cristina M. Risi, Charlotte A. Scarff, Betty Virok, Frank Sobott, Vitold E. Galkin, Stephen P. Muench, Howard D. White 1408-Plat 8:45 am FIRST-IN-CLASS DRUG CANDIDATE (MPH-220) EFFICIENTLY IMPROVES SPASTIC GAIT DISORDERS BY SELECTIVE INHIBITION OF FAST SKELETAL MUSCLE MYOSIN-2. Mate Gyimesi , Adam I. Horvath, Demeter Turos, SHARAD KUMAR SUTHAR, Mate Penzes, Louise Canon, Carlos Kikuti, Kathleen Ruppel, Darshan V. Trivedi, James A. Spudich, Anna Á. Rauscher, Mihaly Kovacs, Samuel Komoly, Anne M. Houdusse, Andras Malnasi- 9:00 am MULTISCALE SIMULATIONS OF THE EFFECTS OF 2'-DEOXY-ATP AND A MYOSIN MUTATION ON ACTOMYOSIN INTERACTIONS. Marcus Hock , Matthew C. Childers, Abigail E. Teitgen, Gary Huber, Kimberly J. McCabe, J. AndrewMcCammon, Michael Regnier, Andrew D. McCulloch 1410-Plat 9:15 am MICROTUBULE DETYROSINATION CONTRIBUTES TO MECHANICAL DYS - FUNCTION IN A RAT MODEL OF HFPEF. Matthew A. Caporizzo , Christina Yingxian Chen, Benjamin L. Prosser 1411-Plat 9:30 am SKELETAL MUSCLE TITIN IG DOMAIN REFOLDING AFTER PASSIVE LENGTHENING. Tim Leonard , Wejdaan Faridi, Darius Ramrattan, Gudrun Schappacher-Tilp, Eng-Kuan Moo, Walter Herzog 1412-Plat 9:45 am ALLOSTERIC DESTABILIZATION OF THE SUPER-RELAXED STATE OF CARDIAC MYOSIN BY HYPERTROPHIC CARDIOMYOPATHY-CAUSING MUTATIONS. Neha Nandwani , Debanjan Bhowmik, Aminah Dawood, Kathleen Ruppel, James A. Spudich 1413-Plat 10:00 am DESIGN AND CHARACTERIZATION OF OPTICALLY CONTROLLABLE FILA - MENTOUS MYOSINS. Sasha Zemsky , Paul V. Ruijgrok, Zev Bryant Csizmadia 1409-Plat

1391-Plat 8:30 am SINGLE MOLECULE INVESTIGATION REVEALS SURSPRISING FEATURES OF BUDDING YEAST SMC 5/6 - DNA INTERACTIONS. Nicoleta-Loredana Tanasie , Pilar Gutiérrez-Escribano, Sigrun Jaklin, Luis Aragón, Johannes Stigler 1392-Plat 8:45 am CAS12A TARGET SEARCH AND CLEAVAGE ON FORCE STRETCHED DNA. Marialucrezia Losito , Quentin M. Smith, Matthew D. Newton, Maria Emanuela Cuomo, David S. Rueda 1393-Plat 9:00 am SINGLE-MOLECULE ANALYSIS OF DNA INTERROGATION BY CAS9 AND CAS12A ON SUPERCOILED DNA. Kevin D.P. Aris , Joshua Cofsky, Addison V. Wright, Ivan E. Ivanov, Ashwin Balaji, Jennifer A. Doudna, Zev Bryant 1394-Plat 9:15 am SPLICEOSOMAL SL1 RNA BINDING TO U1-70K: GAURDIAN UNDER STRESS. Gopika Gopan , Zhaleh Ghaemi, Caitlin Davis, Martin Gruebele 1395-Plat 9:30 am KINETIC ANALYSIS OF GROUP IIC RNP FORMATION. Sarah A. Starcovic , Aaron R. Robart 1396-Plat 9:45 am HOW UPF1 HELICASE ACTIVITY FACILITATES MRNA DECAY. Joseph H. Chapman , Keir C. Neuman, J. R. Hogg 1397-Plat 10:00 am REAL-TIME SINGLE-MOLECULE SEQUENCING OF NUCLEOSOMAL DNA AND COMBINATORY HISTONE MODIFICATIONS DETECTION WITH ZERO- MODE WAVEGUIDES. Pengyu Zheng , Meni Wanunu, Efrat Shema Platform Membrane Structure 8:15 am - 10:15 am, South, Level Two, Room 207/208 Co-Chairs OPTIMISING IMAGE ANALYSIS OF MEMBRANE HYDRATION USING SOL - VATOCHROMIC FLOUROPHORES. Ingela Parmryd , Ainsley Huang, Jeremy Adler 1399-Plat 8:30 am REVISITING HODGKIN AND HUXLEY: AXON MORPHOLOGY AS A BIOPHYSI - CAL PROBLEM. Jacqueline Griswold 1400-Plat 8:45 am THE VESICULAR MEMBRANE 'MEASURES' THE CONCENTRATION OF SEROTONIN CONTAINED IN THE VESICLE. Debsankar Saha Roy, Ankur Gupta, Aditi Verma, Sudipta Maiti 1401-Plat 9:00 am Travel Award Winner CHALLENGING OLD DOGMA WITH NEW TECH: ASYMMETRY OF LIPID ABUNDANCES WITHIN THE PLASMA MEMBRANE. Jessica L. Symons , Milka Doktorova, Kandice R. Levental, Ilya Levental 1402-Plat 9:15 am SELF-ASSEMBLY AND PHASE TRANSITION PROPERTIES OF PURE AR - CHAEAL TETRAETHER LIPIDS. Ahanjit Bhattacharya , Isaac D. Falk, Noah Z. Burns, Steven G. Boxer 1403-Plat 9:30 am Travel Award Winner REPLACING CHOLESTEROL WITH STEROL MODIFIED LIPIDS RESULTS IN IMPROVED LIPOSOMAL STABILITY. Teshani Kumarage , Wally Borden, John Katsaras, Haden L. Scott, Rana Ashkar Ingela Parmryd, University of Gothenburg, Sweden Ahanjit Bhattacharya, Stanford University, USA 1398-Plat 8:15 am

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