Biophysical Society 66th Annual Meeting Program Guide

Platform Single-Molecule Spectroscopy 8:15 am - 10:15 am, South, Level Two, Room 204/205/206 Co-Chairs Allison Squires, University of Chicago, USA Abhijit Lavania, Stanford University, USA 2084-Plat 8:15 am COMBINATION OF SINGLE-MOLECULE FLUORESCENCE AND MASS PHO - TOMETRY. Emanuel Pfitzner , Daniel Cole, Philipp Kukura 2085-Plat 8:30 am DNA ORIGAMI TOOLS FOR SINGLE MOLECULE BIOSENSING. Viktorija Glembockyte , Lennart Grabenhorst, Martina Pfeiffer, Philip Tinnefeld 2086-Plat 8:45 am A NOVEL SINGLE MOLECULE FLUORESCENCE QUENCHING TECHNIQUE FOR MEASURING DISTANCES BELOW 3 NM. Benjamin Ambrose , Victoria E. Hill, Robert A. Shaw, Tristan Johnston-Wood, MatthewWillmott, Cal - lum Johnston, Rebecca Mächtel, Thorben Cordes, Eitan Lerner, J G. Hill, Shimon Weiss, Timothy D. Craggs 2087-Plat 9:00 am CHARACTERIZING PHYSICAL PROPERTIES OF SINGLE CARBOXYSOMES IN THE INTERFEROMETRIC SCATTERING ANTI-BROWNIAN ELECTROKINETIC TRAP. Abhijit A. Lavania , William B. Carpenter, Luke M. Oltrogge, Julia Borden, Davis D. Perez, Allison H. Squires, Peter D. Dahlberg, David F. Sav - age, William E. Moerner 2088-Plat 9:15 am PROBING THE TRANSITION FROM A FAST LOCAL SCALE DIFFUSION TO A SLOW GLOBAL DIFFUSION OF MORPHOGENS IN-VIVO. Ashwin V.S. Nelanuthala , Jagadish Sankaran, Karuna Sampath, Thorsten Wohland 2089-Plat 9:30 am REAL-TIME IMAGING AND DYNAMICS OF SINGLE-PARTICLE ASSEMBLIES FORMED BY THE AIM2 INFLAMMASOME SENSOR ON INDIVIDUAL DNA MOLECULES. Meenakshi Sharma , Eva de Alba 2090-Plat 9:45 am SINGLE MOLECULE REACTION-DIFFUSION WITH SINGLE PHOTON FCS- FRET. Weiqing Xu , Sina Jazani, Zeliha Kilic, Andrea Sottini, Daniel Nettels, Benjamin Schuler, Steve Pressé 2091-Plat 10:00 am MULTIPLEXING SINGLE-MOLECULE FLUORESCENCE MEASUREMENTS WITH SPECTROSCOPICALLY DIVERSE DNA-BASED FRET CONSTRUCTS. Allison H. Squires Platform Protein-Lipid Interactions 8:15 am - 10:15 am, South, Level Two, Room 207/208 Co-Chairs PHOSPHOLIPID INTERACTION SITES IN A LIGAND-GATED ION CHANNEL FROM SIMULATIONS AND CRYO-ELECTRON MICROSCOPY. Cathrine C. Bergh , Urska Rovsnik, Rebecca J. Howard, Erik R. Lindahl 2093-Plat 8:30 am DIVERSE ROLES OF LIPIDS IN ION CONDUCTION BY TMEM16 LIPID SCRAMBLASES. Andrei Kostritskii , Jan-Philipp Machtens 2094-Plat 8:45 am IDENTIFICATION OF OPEN CONFORMATION OF A PLGIC STABILIZED BY OUTER LEAFLET PHOSPHOLIPID. John T. Petroff , Noah Dietzen, Wayland W. Cheng Viviana Monje-Galvan, University at Buffalo, USA Rebecca Howard, Stockholm University, Sweden 2092-Plat 8:15 am

2095-Plat 9:00 am MEMBRANE PHOSPHOLIPIDS CONTROL ACTIVITY OF THE MECHANOSEN - SITIVE K2P CHANNEL TREK1. Philipp Schmidpeter, Aboubacar Wague, John T. Petroff, Wayland W. Cheng, Crina M. Nimigean, Paul M. Riegelhaupt 2096-Plat 9:15 am STATE-DEPENDENT OLIGOMERIZATION AND LIPID SATURATION PREFER - ENCES OF THE KDEL RECEPTOR. Zhiyi Wu, Simon Newstead, Philip C. Biggin 2097-Plat 9:30 am MEMBRANE-MEDIATED MEMBRANE PROTEIN INTERACTIONS DRIVE MEMBRANE PROTEIN ORGANIZATION. Yining Jiang , Batiste Thienpont, James N. Sturgis, Jeremy Dittman, Simon Scheuring 2098-Plat 9:45 am CHARACTERIZATION OF THE PIP-BINDING DOMAINS OF KINDLIN-2 ON LIPID BILAYERS USING A COMBINED NMR-MOLECULAR DYNAMICS AP - PROACH. Jacqueline R. Perodeau, Robert D. Palmere, Ashley D. Bern - stein, Thomas M. Osborn Popp, Andrew J. Nieuwkoop 2099-Plat 10:00 am LIPID SPECIFICITY OF THE MEMBRANE BINDING SIGNAL PROTEIN PLAFP. Martin Kulke , Evan Kurtz, Duncan Boren, Amanda M. Koenig, Susanne Hoffmann-Benning, Josh V. Vermaas Platform Muscle Structure and Function II 8:15 am - 10:15 am, South, Level Two, Room 209/210/211 Co-Chairs Christopher Solis-Ocampo, University of Illinois Chicago, USA Anne M. Houdusse, Inst Curie, France 2100-Plat 8:15 am TRUNCATED TITIN PROTEIN IN DILATED CARDIOMYOPATHY. Quentin McAfee , Christina Yingxian Chen, Yifan Yang, Matthew A. Caporizzo, Michael P. Morley, Apoorva Babu, Sunhye Jeong, Jeffrey Brandimarto, Kenneth C. Bedi, Emily Flam, Joseph Cesare, Thomas P. Cappola, Kenneth B. Margulies, Benjamin L. Prosser, Zolt Arany 2101-Plat 8:30 am DELETION OF CARDIAC FILAMIN C INDUCES SUBCELLULAR REMODELING THAT INHIBITS MECHANICAL FORCE TRANSMISSION. Joseph D. Powers , Canzhao Liu, Xi Fang, Ju Chen, Andrew D. McCulloch 2102-Plat 8:45 am Travel Award Winner WHOLE-CELL MECHANICAL LOADING AND UNLOADING TRIGGERS MORE POST-TRANSLATIONAL MODIFICATIONS IN Z-DISC PROTEINS THAN MYO - SIN ACTIVATORS AND INHIBITORS. Christopher Solís , Elisabeth DiNello, Chad M. Warren, Kyle Dittloff, R. John Solaro 2103-Plat 9:00 am Travel Award Winner INCREASED SUPER-RELAXED MYOSIN UNDERLIES THE TENSION DEFICIT IN RV MYOCYTES FROM HFREF PATIENTS. Vivek P. Jani , Imran Aslam, Weikang Ma, Ilton Cubero Salazar, Henry M. Gong, Anthony Cammarato, Thomas C. Irving, David A. Kass, Steven Hsu 2104-Plat 9:15 am ALTERATIONS OF SARCOMERIC STOICHIOMETRY BY NONSENSE MEDI - ATED DECAY OF MYBPC3 -MRNA IN HYPERTROPHIC CARDIOMYOPATHY PATIENTS WITH TRUNCATION MUTATIONS. Valentin Burkart , Kathrin Kowalski, Tim Holler, Denise Hilfiker-Kleiner, Sean Lal, Cris G. dos Reme - dios, Andreas Perrot, Christine E. Seidman, Maike Kosanke, Theresia Kraft, Judith Montag

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